{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:06:56Z","timestamp":1788991616141,"version":"build-2803163510"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"35","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005203","name":"OeAD-GmbH","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100005203","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010571","name":"Bundesministerium f\u00fcr Bildung, Wissenschaft, Forschung und Technologie","doi-asserted-by":"publisher","award":["RS 15\/2024"],"award-info":[{"award-number":["RS 15\/2024"]}],"id":[{"id":"10.13039\/501100010571","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"Austrian-Serbian commission for Scientific and Technological Cooperation","doi-asserted-by":"publisher","award":["337-00-216\/2023-05\/76"],"award-info":[{"award-number":["337-00-216\/2023-05\/76"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a multielemental and quantitative speciation analysis study with chromatographic inductively coupled plasma\u2013mass spectrometry (ICP\u2013MS\/MS) detection involving four elements (sulfur, selenium, arsenic, and phosphorus) in Asparagus officinalis. The samples were locally purchased and labeled to originate from different regions in two continents. Major compounds were identified and quantified with confirmation based on chemical synthesis in pure form. Nontargeted analysis revealed significant quantitative and qualitative variation for the elemental metabolomes among samples, particularly sulfur and arsenic. Sharp contrast was observed in the diversity of the profiles between sulfur and selenium, providing insight into metabolism selectivity in Asparagus. Inorganic and methylated arsenic were both detected, but their ratios showed wide variation between samples. The present work shows the potential of multielemental speciation analysis with ICP\u2013MS\/MS as a novel dimension for food characterization based on studying heteroatom-tagged metabolome.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c10753","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:07:56Z","timestamp":1788314876000},"page":"28053-28059","source":"Crossref","is-referenced-by-count":0,"title":["Characterizing\nthe Elemental Metabolome in\n                    <i>Asparagus officinalis<\/i>\n                    with Multielemental Speciation\nAnalysis"],"prefix":"10.1021","volume":"74","author":[{"given":"Ivan","family":"Milovanovic","sequence":"first","affiliation":[{"name":"University of Belgrade , , Karnegijeva 4 , ,","place":["Belgrade, Serbia, 11000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Steiner","sequence":"additional","affiliation":[{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Kerschbaumer","sequence":"additional","affiliation":[{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Goessler","sequence":"additional","affiliation":[{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5717-1201","authenticated-orcid":true,"given":"Bassam","family":"Lajin","sequence":"additional","affiliation":[{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]},{"name":"University of Graz , , Universitaetsplatz 1 , ,","place":["Graz, Austria, 8010"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026090917075018400_cit1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.trac.2013.05.016","article-title":"Metabolomics approaches based on mass spectrometry\nfor food safety, quality and traceability","volume":"52","author":"Castro-Puyana","year":"2013","journal-title":"Trends\nAnalyt. 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Spectrom."},{"key":"2026090917075018400_cit4","doi-asserted-by":"publisher","first-page":"127587","DOI":"10.1016\/j.foodchem.2020.127587","article-title":"Arsenic speciation\nin cooked food and its bioaccessible fraction using X-ray absorption\nspectroscopy","volume":"336","author":"Clemente","year":"2021","journal-title":"Food Chem."},{"key":"2026090917075018400_cit5","doi-asserted-by":"publisher","first-page":"mfab047","DOI":"10.1093\/mtomcs\/mfab047","article-title":"Parallel and comparative non-targeted\nmetabolomic speciation analysis of metalloids and their non-metal\nanalogues by HPLC-ICPMS\/MS in mushrooms","volume":"13","author":"Lajin","year":"2021","journal-title":"Metallomics"},{"key":"2026090917075018400_cit6","doi-asserted-by":"publisher","first-page":"8593","DOI":"10.1039\/b905025f","article-title":"Photoresponsive SAMs on gold fabricated from azobenzene-functionalised\nasparagusic acid derivatives","author":"Siemeling","year":"2009","journal-title":"Dalton Trans."},{"key":"2026090917075018400_cit7","doi-asserted-by":"publisher","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"HMDB 5.0: the human metabolome database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucl. 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Hortic."},{"key":"2026090917075018400_cit9","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1016\/S0040-4039(01)84871-1","article-title":"Asparagusic acid, dihydroasparagusic acid and S-acetyldihydroasparagusic\nacid, a new plant growth inhibitors in etiolated young asparagus officinalis","volume":"13","author":"Yanagawa","year":"1972","journal-title":"Tetrahedron Lett."},{"key":"2026090917075018400_cit10","first-page":"1437","volume-title":"Selenium in Chemistry\nand Biochemistry in Comparison to Sulfur","author":"Wessjohann","year":"2007"},{"key":"2026090917075018400_cit11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/psc.654","article-title":"Isosteric\nreplacement of sulfur with other chalcogens in peptides and proteins","volume":"11","author":"Moroder","year":"2005","journal-title":"J. Pept. Sci."},{"key":"2026090917075018400_cit12","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1021\/acs.jnatprod.5b00092","article-title":"Top-down targeted\nmetabolomics reveals a sulfur-containing metabolite with inhibitory\nactivity against angiotensin-converting enzyme in Asparagus officinalis","volume":"78","author":"Nakabayashi","year":"2015","journal-title":"J. Nat. Prod. (Gorakhpur, India)"},{"key":"2026090917075018400_cit13","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1007\/BF01014102","article-title":"Isolation and characterization\nof\nphytotoxic compounds from asparagus (Asparagus officinalis L.) roots","volume":"16","author":"Hartung","year":"1990","journal-title":"J. Chem. Ecol."},{"key":"2026090917075018400_cit14","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/S0040-4039(01)95907-6","article-title":"Asparagusic\nacid-S-oxides, new plant\ngrowth regulators in etiolated young asparagus shoots","volume":"14","author":"Yanagawa","year":"1973","journal-title":"Tetrahedron Lett."},{"key":"2026090917075018400_cit15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1353\/pbm.2013.0031","article-title":"Asparagus,\nurinary odor, and 1, 2-dithiolane-4-carboxylic acid","volume":"56","author":"Mitchell","year":"2013","journal-title":"Perspect. Biol. Med."},{"key":"2026090917075018400_cit16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/chemse\/bjq081","article-title":"Excretion and perception\nof a characteristic odor in urine after asparagus ingestion: a psychophysical\nand genetic study","volume":"36","author":"Pelchat","year":"2011","journal-title":"Chem. 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Int."},{"key":"2026090917075018400_cit19","doi-asserted-by":"publisher","first-page":"8866","DOI":"10.1080\/21655979.2022.2056318","article-title":"Analysis of volatile organic compounds and metabolites\nof three cultivars of asparagus (Asparagus officinalis L.) using E-nose,\nGC-IMS, and LC-MS\/MS","volume":"13","author":"Yang","year":"2022","journal-title":"Bioengineered"},{"key":"2026090917075018400_cit20","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jfca.2015.11.004","article-title":"Comprehensive,\nuntargeted, and qualitative RP-HPLC-ESI-QTOF\/MS2 metabolite profiling\nof green asparagus (Asparagus officinalis)","volume":"46","author":"Jime\u0301nez-Sa\u0301nchez","year":"2016","journal-title":"J. Food Compos. Anal."},{"key":"2026090917075018400_cit21","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jtemb.2013.06.004","article-title":"Toxicological\nproperties of the thiolated inorganic arsenic and arsenosugar metabolite\nthio-dimethylarsinic acid in human bladder cells","volume":"28","author":"Ebert","year":"2014","journal-title":"J. Trace Elem. Med. Biol."},{"key":"2026090917075018400_cit22","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.envint.2018.03.027","article-title":"Thiolated\narsenic in natural systems: What is current, what is new and what\nneeds to be known","volume":"115","author":"Herath","year":"2018","journal-title":"Environ. Int."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c10753","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/35\/28053\/67585068\/acs.jafc.6c10753.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/35\/28053\/67585068\/acs.jafc.6c10753.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T21:14:20Z","timestamp":1788988460000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/35\/28053\/5347426\/Characterizing-the-Elemental-Metabolome-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":22,"journal-issue":{"issue":"35","published-online":{"date-parts":[[2026,8,28]]},"published-print":{"date-parts":[[2026,9,9]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c10753","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}