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S-PYD was preferentially accumulated in zebrafish, and Cd increased the accumulation of PYD by 1.22\u20131.78 times depending on the enantiomer. The mitochondria damage, endoplasmic reticulum hyperplasia, hepatic steatosis, the increase of glucose, triglyceride (TG) and oxidative stress, and the significant alterations of the peroxisome proliferator activated receptor signaling pathway revealed glucolipid metabolism disorders in zebrafish liver. R-PYD induced more serious effects than S-PYD. Cd coexposure alleviated these disorders, as evidenced by reduced TG, oxidative markers, PPAR-related genes, and differentially expressed gene counts, and the effects were more significant for R-PYD. Molecular dynamics simulations revealed that Cd destabilized PYD\u2013PPAR\u03b1 binding, showing antagonistic effects. These findings provided new insights for further toxicological investigations and risk assessments of combined pollutions, enhancing the data support for PYD rational use.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c10824","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:01:57Z","timestamp":1790182917000},"page":"31167-31179","source":"Crossref","is-referenced-by-count":0,"title":["Multiview Reveals\nthe Combined Effects of Chiral Pesticide\nPydiflumetofen and Cadmium on Glucolipid Metabolism in Zebrafish Liver"],"prefix":"10.1021","volume":"74","author":[{"given":"Weixuan","family":"Di","sequence":"first","affiliation":[{"name":"Zhejiang Academy of Agricultural Sciences , , ,","place":["Hangzhou, P. R. China, 310021"]},{"name":"Agricultural Ministry Key Laboratory for Pesticide Residue Detection , ,","place":["Hangzhou, P. R. China, 310021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"Zhejiang Academy of Agricultural Sciences , , ,","place":["Hangzhou, P. R. China, 310021"]},{"name":"Agricultural Ministry Key Laboratory for Pesticide Residue Detection , ,","place":["Hangzhou, P. R. China, 310021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhejiang Academy of Agricultural Sciences , , ,","place":["Hangzhou, P. R. China, 310021"]},{"name":"Agricultural Ministry Key Laboratory for Pesticide Residue Detection , ,","place":["Hangzhou, P. R. China, 310021"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhejiang Academy of Agricultural Sciences , , ,","place":["Hangzhou, P. R. 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