{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:39:50Z","timestamp":1792593590122,"version":"4.5.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"41","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFF1100200"],"award-info":[{"award-number":["2022YFF1100200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009377","name":"Education Department of Hunan Province","doi-asserted-by":"publisher","award":["25B0319"],"award-info":[{"award-number":["25B0319"]}],"id":[{"id":"10.13039\/100009377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014879","name":"Central South University of Forestry and Technology","doi-asserted-by":"publisher","award":["2024YJ006"],"award-info":[{"award-number":["2024YJ006"]}],"id":[{"id":"10.13039\/501100014879","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32603353"],"award-info":[{"award-number":["32603353"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Province 2025 Furong Plan Youth Talent Project","award":["2025QT-40"],"award-info":[{"award-number":["2025QT-40"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exercise-induced fatigue is linked to oxidative stress, inflammation and intestinal dysbiosis. Narirutin (NAR), a natural flavonoid, lacks systematic evidence and mechanistic clarification against exercise fatigue. Herein, a forced exercise fatigue mouse model was constructed, and behavioral, biochemical, histological and multiomics analyses including 16S rRNA sequencing, untargeted metabolomics, transcriptomics and RT-qPCR were performed. Fecal microbiota transplantation (FMT) and antibiotic-mediated microbiota depletion further verified the causal role of gut microbiota. NAR dose-dependently improved exercise endurance, muscle strength, glycogen storage, oxidative status and inflammatory profiles. It restored gut microbial diversity, remodelled microbial composition and altered metabolic signatures. Multiomics integration indicated NAR regulated immune genes via the gut microbiota-metabolite-gene axis. FMT reproduced antifatigue effects, whereas antibiotic treatment eliminated NAR protection. This study demonstrates that NAR alleviates exercise-induced fatigue largely relying on intact gut microbiota, although microbiota-independent peripheral effects cannot be fully excluded. These findings support its exploitation as a natural antifatigue functional component.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c11203","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T15:01:30Z","timestamp":1791730890000},"page":"32426-32447","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects\nof Narirutin Against Exercise-Induced\nFatigue in Mice: Insights from Integrated Microbiome, Metabolome,\nand Transcriptome Analysis"],"prefix":"10.1021","volume":"74","author":[{"given":"Zhongxing","family":"Chu","sequence":"first","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baitong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quankang","family":"Liu","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-5987","authenticated-orcid":true,"given":"Yaoying","family":"Zeng","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-292X","authenticated-orcid":true,"given":"Zuomin","family":"Hu","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-544X","authenticated-orcid":true,"given":"Feijun","family":"Luo","sequence":"additional","affiliation":[{"name":"Central South University of Forestry and Technology , , , ,","place":["Changsha, Hunan, China, 410004"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"issue":"24","key":"2026102109085180600_cit1","doi-asserted-by":"publisher","first-page":"3072","DOI":"10.1080\/02640414.2025.2573575","article-title":"The impact of mental fatigue on physiological\ntolerance and athletic performance in athletes: Exploring central\nand peripheral mechanisms","volume":"43","author":"Qian","year":"2025","journal-title":"Journal of Sports\nSciences"},{"issue":"3","key":"2026102109085180600_cit2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3390\/nu18030502","article-title":"Gut microbiota\nand exercise-induced fatigue: a narrative review of mechanisms, nutritional\ninterventions, and future directions","volume":"18","author":"Zhao","year":"2026","journal-title":"Nutrients"},{"issue":"11","key":"2026102109085180600_cit3","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.3390\/foods13111680","article-title":"Dietary strategies\nto improve exercise performance by modulating the gut microbiota","volume":"13","author":"Zhang","year":"2024","journal-title":"Foods"},{"issue":"2","key":"2026102109085180600_cit4","doi-asserted-by":"publisher","first-page":"9250626","DOI":"10.26599\/FSHW.2025.9250626","article-title":"Critical review on\nanti-fatigue effects of natural dietary products: present insights\nand future trends","volume":"15","author":"Jeepipalli","year":"2026","journal-title":"Food Sci. 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Ethnopharmacol."},{"issue":"1","key":"2026102109085180600_cit29","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1080\/13880209.2016.1244553","article-title":"Effects of\nnaringin on physical fatigue and serum MMP-9 concentration in female\nrats","volume":"55","author":"Zamanian","year":"2017","journal-title":"Pharmaceutical Biology"},{"issue":"19","key":"2026102109085180600_cit30","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1177\/15353702221117128","article-title":"Antifatigue\neffect of naringin on improving antioxidant capacity and mitochondrial\nfunction and preventing muscle damage","volume":"247","author":"Chen","year":"2022","journal-title":"Experimental\nBiology and Medicine"},{"issue":"10","key":"2026102109085180600_cit31","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.3390\/nu17101686","article-title":"Exercise,\ndiet, and brain health:\nfrom the perspective of gut microbiota regulation","volume":"17","author":"Zhang","year":"2025","journal-title":"Nutrients"},{"key":"2026102109085180600_cit32","doi-asserted-by":"publisher","first-page":"112568","DOI":"10.1016\/j.foodres.2023.112568","article-title":"Effects\nof prebiotics on intestinal\nphysiology, neuropsychological function, and exercise capacity of\nmice with sleep deprivation","volume":"165","author":"Chung","year":"2023","journal-title":"Food Res. 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Sci."}],"container-title":["Journal of Agricultural\nand Food Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jafc.6c11203","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/41\/32426\/68812879\/acs.jafc.6c11203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jafcau\/article-pdf\/74\/41\/32426\/68812879\/acs.jafc.6c11203.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:49:38Z","timestamp":1792590578000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jafcau\/article\/74\/41\/32426\/5448604\/Protective-Effects-of-Narirutin-Against-Exercise"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,11]]},"references-count":35,"journal-issue":{"issue":"41","published-online":{"date-parts":[[2026,10,11]]},"published-print":{"date-parts":[[2026,10,21]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jafc.6c11203","relation":{},"ISSN":["0021-8561","1520-5118"],"issn-type":[{"value":"0021-8561","type":"print"},{"value":"1520-5118","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,11]]}}}