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Its major aggregation pheromone component neryl (S)-2-methylbutanoate (NMB) is a strong attractant for adult females. However, the molecular mechanisms underlying NMB detection, particularly the role of odorant-binding proteins, remain poorly defined. This study identified and functionally characterized FoccOBP56h as a key mediator of the behavioral response to NMB. qRT-PCR showed that FoccOBP56h is predominantly expressed in the antennae and is significantly upregulated following NMB exposure. Fluorescence binding assays revealed that recombinant FoccOBP56h exhibited high affinity for NMB. Molecular docking and site-directed mutagenesis indicated that Asn90, Met104, and Val105 are important for NMB binding. RNAi-mediated knockdown of FoccOBP56h significantly reduced female attraction to NMB. These findings identify FoccOBP56h as a promising molecular target involved in NMB detection, providing a foundation for developing semiochemical-based strategies for insect behavior manipulation in pest management.<\/jats:p>","DOI":"10.1021\/acs.jafc.6c11676","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:01:38Z","timestamp":1789142498000},"page":"29487-29498","source":"Crossref","is-referenced-by-count":0,"title":["Odorant-Binding\nProtein 56 h Contributes to the Behavioral\nResponse of\n                    <i>Frankliniella occidentalis<\/i>\n                    to Neryl (\n                    <i>S<\/i>\n                    )-2-Methylbutanoate"],"prefix":"10.1021","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9217-2437","authenticated-orcid":true,"given":"Yueqin","family":"Zheng","sequence":"first","affiliation":[{"name":"Fujian Academy of Agricultural Sciences , , ,","place":["Fuzhou, China, 350013"]},{"name":"Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture , ,","place":["Fuzhou, China, 350013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Fujian Academy of Agricultural Sciences , , ,","place":["Fuzhou, China, 350013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Academy of Agricultural Sciences , , ,","place":["Fuzhou, China, 350013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houjun","family":"Tian","sequence":"additional","affiliation":[{"name":"Fujian Academy of Agricultural Sciences , , ,","place":["Fuzhou, China, 350013"]},{"name":"Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture , ,","place":["Fuzhou, China, 350013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Academy of Agricultural Sciences , , ,","place":["Fuzhou, China, 350013"]},{"name":"Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture , ,","place":["Fuzhou, China, 350013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Lin","sequence":"additional","affiliation":[{"name":"Fujian Academy of Agricultural Sciences , , ,","place":["Fuzhou, China, 350013"]},{"name":"Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture , ,","place":["Fuzhou, China, 350013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Academy of Agricultural Sciences , , ,","place":["Fuzhou, China, 350013"]},{"name":"Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture , ,","place":["Fuzhou, China, 350013"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wei","sequence":"additional","affiliation":[{"name":"Fujian Academy of Agricultural Sciences , , ,","place":["Fuzhou, China, 350013"]},{"name":"Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Fuzhou Scientific Observing and Experimental Station of Crop Pests of Ministry of Agriculture , ,","place":["Fuzhou, China, 350013"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"2026092310082725900_cit1","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1146\/annurev-ento-010715-023523","article-title":"Plasticity in insect olfaction: to\nsmell or not to smell?","volume":"61","author":"Gadenne","year":"2016","journal-title":"Annu. 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Mol. Biol."},{"key":"2026092310082725900_cit5","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/BF00328015","article-title":"Immunocytochemical\nlocalization of\npheromone-binding protein in moth antennae","volume":"270","author":"Steinbrecht","year":"1992","journal-title":"Cell Tissue Res."},{"key":"2026092310082725900_cit6","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1007\/s10886-004-7941-3","article-title":"Insect olfactory receptors:\ncontributions of molecular\nbiology to chemical ecology","volume":"30","author":"Jacquin-Joly","year":"2004","journal-title":"J. Chem. Ecol."},{"key":"2026092310082725900_cit7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1002\/ps.6606","article-title":"Ligand-binding properties\nof odorant-binding protein\n6 in Athetis lepigone to sex pheromones and maize\nvolatiles","volume":"78","author":"Li","year":"2022","journal-title":"Pest Manag. 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Sci."},{"key":"2026092310082725900_cit14","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1002\/ps.7928","article-title":"Identification\nof aggregation pheromones released by the stick tea thrips (Dendrothrips minowai) larvae and their application for controlling\nthrips in tea plantations","volume":"80","author":"Xiu","year":"2024","journal-title":"Pest Manag. Sci."},{"key":"2026092310082725900_cit15","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/ps.8445","article-title":"Identification\nand field verification of the aggregation pheromone components produced\nby male Holotrichia parallela Motschulsky (Coleoptera:\nScarabaeidae)","volume":"81","author":"Qu","year":"2025","journal-title":"Pest Manag. 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Ecol."},{"key":"2026092310082725900_cit24","doi-asserted-by":"publisher","first-page":"7574","DOI":"10.1021\/acs.jafc.4c10456","article-title":"Molecular characterization\nand binding properties of odorant binding protein 7 in western flower\nthrips, Frankliniella occidentalis (Thysanoptera:\nThripidae)","volume":"73","author":"Cao","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"2026092310082725900_cit25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1146\/annurev-ento-011019-024947","article-title":"Invasion\nbiology, ecology, and management of western flower thrips","volume":"65","author":"Reitz","year":"2020","journal-title":"Annu. Rev. Entomol."},{"key":"2026092310082725900_cit26","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10340-020-01212-y","article-title":"Competitive interaction\nbetween Frankliniella occidentalis and locally present thrips species: a global\nreview","volume":"94","author":"Wu","year":"2021","journal-title":"J. Pest Sci."},{"key":"2026092310082725900_cit27","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3390\/plants13020273","article-title":"Nitrogen deficiency\nenhances eggplant defense against western flower thrips via the induction\nof the jasmonate pathway","volume":"13","author":"Zheng","year":"2024","journal-title":"Plants"},{"issue":"15","key":"2026092310082725900_cit28","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for\nIllumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"issue":"1","key":"2026092310082725900_cit29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool\nfor the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. 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Pharmacol."},{"key":"2026092310082725900_cit35","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s000180300032","article-title":"Biochemical characterization\nand bacterial expression\nof an odorant-binding protein from Locusta migratoria","volume":"60","author":"Ban","year":"2003","journal-title":"Cell. Mol. 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Sci."},{"key":"2026092310082725900_cit39","doi-asserted-by":"publisher","first-page":"100069","DOI":"10.1016\/j.napere.2024.100069","article-title":"Insight into\ninsect odorant binding\nproteins: an alternative approach for pest management","volume":"8","author":"Rana","year":"2024","journal-title":"J. Nat. Pestic. Res."},{"key":"2026092310082725900_cit40","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1093\/ee\/nvx141","article-title":"Olfactory response\nof the predatory\nbug Orius laevigatus (Hemiptera: Anthocoridae) to\nthe aggregation pheromone of its prey, Frankliniella occidentalis (Thysanoptera: Thripidae)","volume":"46","author":"Vaello","year":"2017","journal-title":"Environ. Entomol."},{"key":"2026092310082725900_cit41","doi-asserted-by":"publisher","first-page":"105777","DOI":"10.1016\/j.isci.2022.105777","article-title":"Chemosensory detection of aversive concentrations of ammonia and\nbasic volatile amines in insects","volume":"26","author":"Clark","year":"2023","journal-title":"iScience"},{"key":"2026092310082725900_cit42","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/nature07983","article-title":"Select Drosophila glomeruli mediate\ninnate olfactory attraction and aversion","volume":"459","author":"Semmelhack","year":"2009","journal-title":"Nature"},{"key":"2026092310082725900_cit43","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.1002\/ps.7654","article-title":"Host plant\nrecognition by two odorant-binding proteins\nin Rhynchophorus ferrugineus (Coleoptera: Curculionidae)","volume":"79","author":"Huang","year":"2023","journal-title":"Pest Manag. 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Sci."},{"key":"2026092310082725900_cit46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053840","article-title":"Crystallographic\nobservation of pH-induced conformational changes in the Amyelois transitella pheromone-binding protein AtraPBP1","volume":"8","author":"di Luccio","year":"2013","journal-title":"PLoS One"},{"key":"2026092310082725900_cit47","doi-asserted-by":"publisher","first-page":"105513","DOI":"10.1016\/j.pestbp.2023.105513","article-title":"Binding\nproperties\nof chemosensory protein 12 in Riptortus pedestris to aggregation pheromone (E)-2-Hexenyl (Z)-3-Hexenoate","volume":"194","author":"Yin","year":"2023","journal-title":"Pestic. Biochem. Physiol."},{"key":"2026092310082725900_cit48","doi-asserted-by":"publisher","DOI":"10.7554\/elife.57264","article-title":"How to measure\nand evaluate binding affinities","volume":"9","author":"Jarmoskaite","year":"2020","journal-title":"eLife"},{"key":"2026092310082725900_cit49","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jinsphys.2012.12.004","article-title":"Two Minus-C odorant binding proteins from Helicoverpa armigera display higher ligand binding affinity at acidic\npH than neutral pH","volume":"59","author":"Li","year":"2013","journal-title":"J. Insect Physiol."},{"key":"2026092310082725900_cit50","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jmb.2008.04.048","article-title":"Structural\nbasis of the honey bee\nPBP pheromone and pH-induced conformational change","volume":"380","author":"Pesenti","year":"2008","journal-title":"J. Mol. 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