{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:43:16Z","timestamp":1791895396987,"version":"4.3.4"},"reference-count":122,"publisher":"American Chemical Society (ACS)","issue":"21","license":[{"start":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T00:00:00Z","timestamp":1761177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005714","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DQDBM7FGJPC5"],"award-info":[{"award-number":["DQDBM7FGJPC5"]}],"id":[{"id":"10.13039\/100005714","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022753","name":"Iowa State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009227","name":"Iowa State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["22599"],"award-info":[{"award-number":["22599"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2025,11,10]]},"DOI":"10.1021\/acs.jcim.5c01809","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T03:34:23Z","timestamp":1761276863000},"page":"12068-12087","source":"Crossref","is-referenced-by-count":2,"title":["AstraMEV (AI-Guided Structural Assembly of Multi-Epitope Vaccines) Against Infectious Bronchitis Virus"],"prefix":"10.1021","volume":"65","author":[{"given":"Supantha","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Engineering","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]},{"name":"Nanovaccine Institute","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Gates","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]},{"name":"Nanovaccine Institute","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahil","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]},{"name":"Nanovaccine Institute","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riza","family":"Danurdoro","sequence":"additional","affiliation":[{"name":"Department of Computer Science","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakib","family":"Ferdous","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]},{"name":"Nanovaccine Institute","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1957-4613","authenticated-orcid":true,"given":"Ratul","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Engineering","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]},{"name":"Nanovaccine Institute","place":["Ames, United States"]},{"name":"Iowa State University","place":["Ames, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,10,23]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001828"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3390\/v15122285"},{"key":"ref3\/cit3","first-page":"413","volume":"78","author":"Schalk A. F.","year":"1931","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","DOI":"10.1596\/27118","volume-title":"World Livestock Disease Atlas: A Quantitative Analysis of Global Animal Health Data (2006\u20132009)","author":"World Bank and TAFS forum","year":"2011"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.20506\/rst.34.3.2411"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1637\/0005-2086-64.4.482"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1325346"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-3-591"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2018.04.013"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00627-16"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.02011-09"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-814966-9.00003-2"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/1144924"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06987-2"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/03079459808419370"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-2862-5.50033-7"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2017.01.002"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-021-01008-7"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11020302"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2021.01.004"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-023-10535-0"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39299-8"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.04.009"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.20"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.29"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1516-5"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-5517-x"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14686"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.04.031"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2022.1116400"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.06.116"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.92"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1552-9"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1080\/03079457.2011.566260"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.02.015"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06415-8"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38328-5"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2024.08.029"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001642"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.75.1.506-512.2001"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2007.08.016"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa379"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700893"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-018-0594-6"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4497"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx108"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1186\/s41231-020-00063-0"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102030"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac446"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-8-4"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108926"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2022.01.036"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49354-z"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00465-24"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245072"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1251716"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-022-10438-6"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1016\/j.microb.2025.100320"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2024.101745"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.02.009"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-53048-6"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-890-0:571"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10286"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.3390\/ph7030220"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbae153"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1101\/2022.04.08.487609"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm256"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv485"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1126\/science.add2187"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1126\/science.ade2574"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-011-9514-4"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1105"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22711"},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1021\/jp003020w"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.1063\/1.2408420"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1063\/1.470117"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13051147"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.3389\/fbinf.2025.1562997"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1101\/2024.06.03.597183"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009862"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-8-361"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.05.048"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/4.2.155"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.29.1_supplement.891.8"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7000-1_24"},{"key":"ref90\/cit90","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2020.08.005"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(96)00147-5"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1107\/S2059798317009834"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci8110273"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2022.04.004"},{"key":"ref95\/cit95","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2013.03.008"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.3390\/v13091698"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2020.02.001"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-021-05322-5"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10941"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00738"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00645"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c00374"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1063\/1.4978893"},{"key":"ref104\/cit104","doi-asserted-by":"publisher","DOI":"10.1021\/ci3001919"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00055"},{"key":"ref106\/cit106","author":"Dey S.","year":"2025","journal-title":"arXiv"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105713"},{"key":"ref108\/cit108","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2011.0036"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1177\/1721727X17703886"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2023.105093"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-020-04690-8"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-024-04022-6"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-023-09403-2"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2024.101782"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci11120659"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27662"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-017-1004-8"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-351"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.71725"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA06476J"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2017.0030"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.671235"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c01809","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c01809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T09:11:54Z","timestamp":1762765914000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c01809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":122,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,11,10]]}},"alternative-id":["10.1021\/acs.jcim.5c01809"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c01809","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]}}}