{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T09:00:29Z","timestamp":1780909229854,"version":"3.54.1"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2026,6,8]]},"DOI":"10.1021\/acs.jcim.5c02320","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:01:31Z","timestamp":1777442491000},"page":"6544-6564","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Insights into the Conformational Dynamics of the Novel Dispersion Sensor Histidine Kinase DspS"],"prefix":"10.1021","volume":"66","author":[{"given":"Christabel Ming Ming","family":"Koh","sequence":"first","affiliation":[{"name":"Faculty of Engineering, Computing, and Science","place":["Kuching, Malaysia"]},{"name":"Swinburne University of Technology Sarawak","place":["Kuching, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siaw San","family":"Hwang","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Computing, and Science","place":["Kuching, Malaysia"]},{"name":"Swinburne University of Technology Sarawak","place":["Kuching, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bee Theng","family":"Lau","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Computing, and Science","place":["Kuching, Malaysia"]},{"name":"Swinburne University of Technology Sarawak","place":["Kuching, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5889-1393","authenticated-orcid":true,"given":"Enzo A.","family":"Palombo","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biotechnology","place":["Hawthorn, Australia"]},{"name":"Swinburne University of Technology","place":["Hawthorn, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irine Runnie Henry","family":"Ginjom","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Computing, and Science","place":["Kuching, Malaysia"]},{"name":"Swinburne University of Technology Sarawak","place":["Kuching, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Heng Xuan","family":"Ha","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Computing, and Science","place":["Kuching, Malaysia"]},{"name":"Swinburne University of Technology Sarawak","place":["Kuching, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-5160","authenticated-orcid":true,"given":"Taufiq","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8497-5953","authenticated-orcid":true,"given":"Xavier","family":"Chee Wezen","sequence":"additional","affiliation":[{"name":"Faculty of Engineering, Computing, and Science","place":["Kuching, Malaysia"]},{"name":"Swinburne University of Technology Sarawak","place":["Kuching, Malaysia"]},{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine","place":["Singapore, Singapore"]},{"name":"National University of Singapore","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.87"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.01.016"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2015.04.002"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","unstructured":"Kenney, L. J.; Anand, G. S. EnvZ\/OmpR Two-Component Signaling: An Archetype System That Can Function Noncanonically\n                      EcoSal Plus\n                      2020; Vol. 9 10.1128\/ecosalplus.esp-0001-2019.","DOI":"10.1128\/ecosalplus.esp-0001-2019"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2025.1509037"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2010.01.008"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02570-23"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00549"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01214-08"},{"key":"ref10\/cit10","unstructured":"Amari, D. T. Molecular Regulation of the Signaling Molecule Cis-2-decenoic Acid in\n                      Pseudomonas aeruginosa\n                      . Binghamton. 2013."},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26165110"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115933"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201700197"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.3390\/biom11101524"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-55671-3"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015999"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah6345"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-68206-z"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107265"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-88468-5"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2019.08.001"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010073"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03464-23"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8284"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/S41401-025-01603-W"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28164-4"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm290"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1063\/1.2945165"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.9b00761"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.667"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.08.083"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501234102"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002878"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0807576105"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036688"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01214-08"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jp302103t"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.3c00614"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1134\/S0026893308060150"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00609"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ct200163c"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3795(00)00095-1"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.laa.2004.10.026"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1142\/9789814295291_0025"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01197"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.4324\/9780203771587"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.2c01246"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108478"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.1c01217"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/ct500090q"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.1c00254"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c02320","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.5c02320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T08:11:35Z","timestamp":1780906295000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.5c02320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":51,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6,8]]}},"alternative-id":["10.1021\/acs.jcim.5c02320"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.5c02320","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]}}}