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Recent advancements have shown that the powerful representation capabilities of Large Language Models on textual molecular data, combined with the relational learning strengths of Attention-based Graph Neural Networks, offer a new paradigm for capturing both the semantic and structural information about molecules. In this study, we introduce a novel Dual-Attention Multimodal framework for Graphs and Sequence-based representations, so-called DAM-GS. We evaluated our approach on multiple benchmark data sets covering diverse molecular prediction tasks. Experimental results showed that DAM-GS had outperformed the compared graph-based methods in most dataset\u2013split settings. By leveraging the complementary advantages of graph-based and language-based modeling, our framework provides a promising solution for molecular property prediction with broad applications in drug discovery and computational molecular science.<\/jats:p>","DOI":"10.1021\/acs.jcim.5c02663","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:02:15Z","timestamp":1786651335000},"page":"9787-9802","source":"Crossref","is-referenced-by-count":0,"title":["Dual-Attention\nMultimodal Framework for Molecular\nProperty Prediction"],"prefix":"10.1021","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7474-5193","authenticated-orcid":true,"given":"Bay Van","family":"Nguyen","sequence":"first","affiliation":[{"name":"Ho Chi Minh City Open University , , 97 Vo Van Tan , Xuan Hoa, ,","place":["Ho Chi Minh City, Viet Nam, 700000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3464-3894","authenticated-orcid":true,"given":"Vinh","family":"Truong","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City Open University , , 97 Vo Van Tan , Xuan Hoa, ,","place":["Ho Chi Minh City, Viet Nam, 700000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1052-0988","authenticated-orcid":true,"given":"Ha","family":"Duong Thi Hong","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City Open University , , 97 Vo Van Tan , Xuan Hoa, ,","place":["Ho Chi Minh City, Viet Nam, 700000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiet","family":"Tran-Trung","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City Open University , , 97 Vo Van Tan , Xuan Hoa, ,","place":["Ho Chi Minh City, Viet Nam, 700000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-5245","authenticated-orcid":true,"given":"Thanh-Hoang","family":"Nguyen-Vo","sequence":"additional","affiliation":[{"name":"Wellington Institute of Technology , , 21 Kensington Avenue , ,","place":["Lower Hutt, New Zealand, 5012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-6664","authenticated-orcid":true,"given":"Binh P.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Victoria University of Wellington , , Kelburn Parade , ,","place":["Wellington, New Zealand, 6012"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"2026083104341333900_cit1","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1021\/acscentsci.8b00507","article-title":"PotentialNet for\nMolecular Property Prediction","volume":"4","author":"Feinberg","year":"2018","journal-title":"ACS Cent. 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