{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:49:23Z","timestamp":1782488963456,"version":"3.54.5"},"reference-count":22,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["OPUS 2023\/49\/B\/NZ7\/03340"],"award-info":[{"award-number":["OPUS 2023\/49\/B\/NZ7\/03340"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Chem. Inf. Model."],"published-print":{"date-parts":[[2026,5,25]]},"DOI":"10.1021\/acs.jcim.6c00316","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:35:22Z","timestamp":1778474122000},"page":"6141-6158","source":"Crossref","is-referenced-by-count":0,"title":["Decoding Prolonged Residence Time of 5-HT\n                    <sub>2A<\/sub>\n                    Receptor Antagonists: Insights from Ritanserin Derivatives"],"prefix":"10.1021","volume":"66","author":[{"given":"Szymon K.","family":"Kordylewski","sequence":"first","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga","family":"Kurowska","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"N\u0119dza","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Sata\u0142a","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland"},{"name":"Department of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, Krak\u00f3w 30-387, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryszard","family":"Bugno","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2891-5603","authenticated-orcid":true,"given":"Sabina","family":"Podlewska","sequence":"additional","affiliation":[{"name":"Maj Institute of Pharmacology Polish Academy of Sciences, Smetna 12, 31-343 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1909.sp001344"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2082"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2021.1948997"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.18"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16104"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/bi8002023"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-025-00748-z"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.4c00740"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00710"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2025.110622"},{"key":"ref11\/cit11","unstructured":"Josephine Kennis, L. E.; Vandenberk, J.; Carolus Mertens, J. Novel ((Bis(Aryl)Methylene)-1-Piperidinyl)Alkyl-Pyrimidinones. EP-0110435-A1, 1982."},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1013000"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57956-7"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.033"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5c01832"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/ct500040r"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00036"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b00230"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.crstbi.2021.04.001"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.01.003"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.12.033"}],"container-title":["Journal of Chemical Information and Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.6c00316","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jcim.6c00316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:10:03Z","timestamp":1782486603000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jcim.6c00316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5,25]]}},"alternative-id":["10.1021\/acs.jcim.6c00316"],"URL":"https:\/\/doi.org\/10.1021\/acs.jcim.6c00316","relation":{},"ISSN":["1549-9596","1549-960X"],"issn-type":[{"value":"1549-9596","type":"print"},{"value":"1549-960X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]}}}