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Despite recent advances in machine learning methods, existing models often rely solely on either sequence information or protein pocket structures. This limitation prevents these models from fully capturing the critical three-dimensional (3D) physical information that governs molecular recognition, thus failing to meet the high-precision demands of drug discovery. To address this, we introduce HelixDTA, a deep learning framework featuring a parallel dual-branch architecture that independently learns representations from two distinct but complementary modalities: sequence context and complete target structures. By integrating sequence-derived features with structure-derived features at the prediction layer, this architecture preserves modality-specific insights while characterizing drug\u2013target interactions more comprehensively. HelixDTA achieved strong and competitive performance on the Davis and KIBA benchmarks and maintained clear advantages across most similarity-based cold-start settings, demonstrating robust generalization to compounds with unseen scaffolds and novel protein targets. Furthermore, its built-in attention mechanism enhances interpretability by highlighting molecular regions that contribute to affinity prediction. Finally, a WRN case study demonstrates the potential use of HelixDTA for structure-aware allosteric candidate prioritization by integrating complete target-level structural context with docking-based pose inspection. In conclusion, HelixDTA offers a highly accurate, interpretable, and robust solution for DTA prediction. It highlights the value of integrating structural context with sequence-derived information and demonstrates significant potential to empower precision drug design and accelerate the drug discovery pipeline.<\/jats:p>","DOI":"10.1021\/acs.jcim.6c01759","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:02:24Z","timestamp":1789574544000},"page":"12128-12142","source":"Crossref","is-referenced-by-count":0,"title":["HelixDTA: Dual-Branch\nSequence\u2013Structure Learning\nwith Complete Target Structures for Robust and Interpretable Drug\u2013Target\nAffinity Prediction"],"prefix":"10.1021","volume":"66","author":[{"given":"Shang","family":"Lou","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Hefei, Anhui Province, China, 230031"]},{"name":"University of Science and Technology of China , , , ,","place":["Hefei, Anhui Province, China, 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China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Qingdao, Shandong Province, China, 266000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Yi","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Hefei, Anhui Province, China, 230031"]},{"name":"University of Science and Technology of China , , , ,","place":["Hefei, Anhui Province, China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology , , ,","place":["Harbin, China, 150001"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Hefei, Anhui Province, China, 230031"]},{"name":"University of Science and Technology of China , , , ,","place":["Hefei, Anhui Province, China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beilei","family":"Wang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences , , , ,","place":["Hefei, Anhui Province, China, 230031"]},{"name":"University of Science and Technology of China , , , ,","place":["Hefei, Anhui Province, China, 230026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Anhui Zhianxin Information Technology Co., Ltd , , ,","place":["Hefei, Anhui Province, China, 230092"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Qian","sequence":"additional","affiliation":[{"name":"Qianhong Chinese Medicine Clinic , , ,","place":["Paris, France, 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