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Here, we examine how oxygen quadrupole scaling affects AMOEBA d-glucose models generated with Poltype2 by comparing the standard 0.7 scaling with full 1.0 scaling for \u03b1- and \u03b2-d-glucose monosaccharides, 1\u21924-linked oligomers, and concentrated solutions. Increasing the oxygen quadrupole scaling from 0.7 to 1.0 improves monosaccharide hydration free energies, increases d-glucose\u2013water hydrogen-bond counts and lifetimes, and strengthens hydroxyl electric-field projections without substantially altering hydration-shell structure. In 1\u21924-linked d-glucose oligomers, full scaling also enhances intramolecular hydrogen bonding, restricts conformational sampling, and produces more organized chain electrostatics. Electric-field decompositions indicate that OH2 and OH3 in \u03b11\u21924 d-glucose oligomers are strongly coupled to intramolecular hydrogen-bond networks, whereas OH6 remains more water-controlled and solvent-accessible. Diffusion simulations show that both models perform reasonably well at concentrations up to 0.5 mol\/kg but overestimate the slowdown of d-glucose mobility at higher concentrations, especially with 1.0 scaling. Overall, full oxygen quadrupole scaling improves local hydration, hydroxyl electrostatics, and diffusion behavior in the lower-concentration regime. Further refinement is needed to balance these stronger interactions against transport properties in highly concentrated carbohydrate solutions, which may be particularly relevant to materials applications.<\/jats:p>","DOI":"10.1021\/acs.jcim.6c02832","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:01:57Z","timestamp":1791000117000},"page":"13453-13466","source":"Crossref","is-referenced-by-count":0,"title":["Refining AMOEBA\nElectrostatics for\n                    <scp>d<\/scp>\n                    -Glucose\nand 1\u21924-Linked\n                    <scp>d<\/scp>\n                    -Glucose Oligosaccharides"],"prefix":"10.1021","volume":"66","author":[{"given":"Luke A.","family":"Newman","sequence":"first","affiliation":[{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]},{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley","family":"Ophof","sequence":"additional","affiliation":[{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-4441","authenticated-orcid":true,"given":"Valerie","family":"Vaissier Welborn","sequence":"additional","affiliation":[{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]},{"name":"Virginia Tech , , , ,","place":["Blacksburg, Virginia, United States, 24061"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"2026102608100876700_cit1","volume-title":"Lehninger principles\nof biochemistry","author":"Nelson","year":"2008"},{"key":"2026102608100876700_cit2","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1021\/cr940283b","article-title":"Glycobiology:\ntoward understanding the function of sugars","volume":"96","author":"Dwek","year":"1996","journal-title":"Chem. 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