{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:19:43Z","timestamp":1784067583510,"version":"3.55.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"1","license":[{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T00:00:00Z","timestamp":1641254400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA188252"],"award-info":[{"award-number":["R01 CA188252"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2022,1,13]]},"DOI":"10.1021\/acs.jmedchem.1c01509","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T20:17:31Z","timestamp":1641327451000},"page":"343-368","source":"Crossref","is-referenced-by-count":27,"title":["Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors"],"prefix":"10.1021","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-0408","authenticated-orcid":true,"given":"Ding","family":"Xue","sequence":"first","affiliation":[{"name":"Departments of Medicinal Chemistry, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8261-3286","authenticated-orcid":true,"given":"Yibin","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Medicinal Chemistry, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armita","family":"Kyani","sequence":"additional","affiliation":[{"name":"Departments of Medicinal Chemistry, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyeeta","family":"Roy","sequence":"additional","affiliation":[{"name":"Departments of Medicinal Chemistry, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipeng","family":"Dai","sequence":"additional","affiliation":[{"name":"Departments of Medicinal Chemistry, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"},{"name":"Pharmaceutical Sciences, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus\rResearch Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-2126","authenticated-orcid":true,"given":"Duxin","family":"Sun","sequence":"additional","affiliation":[{"name":"Departments of Medicinal Chemistry, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"},{"name":"Pharmaceutical Sciences, College of Pharmacy, Rogel Cancer Center, University of Michigan, North Campus\rResearch Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-7131","authenticated-orcid":true,"given":"Nouri","family":"Neamati","sequence":"additional","affiliation":[{"name":"Departments of Medicinal Chemistry, University of Michigan, North Campus Research Complex, 1600 Huron Parkway, Ann Arbor, Michigan 48109, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2022,1,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-017-0168-x"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10769"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29934"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.107"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.032"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0019-5"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2017.09.002"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1172\/jci81568"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.152"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1101\/gad.188292.112"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.08.015"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.009"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.12.013"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau1167"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.02.003"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15051-z"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-17-3070"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01013"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.can-15-2534"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1042\/bj20140620"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00294"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.03.007"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.cd-12-0263"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.mct-15-1021"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1172\/jci67232"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.112"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s40170-015-0138-0"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0052-4"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.06.003"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1177\/106002809302701004"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2019.37.15_suppl.3014"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/s1359-6446(04)03280-5"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201708590"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1039\/c4ra14056g"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.1c01509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T12:53:18Z","timestamp":1682513598000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.1c01509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,4]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,13]]}},"alternative-id":["10.1021\/acs.jmedchem.1c01509"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.1c01509","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,4]]}}}