{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:05:11Z","timestamp":1788318311989,"version":"build-2803163510"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Research Councils UK","doi-asserted-by":"publisher","award":["EP\/S023518\/1"],"award-info":[{"award-number":["EP\/S023518\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["RSRPR1211057"],"award-info":[{"award-number":["RSRPR1211057"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/S033947\/1"],"award-info":[{"award-number":["MR\/S033947\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","award":["511"],"award-info":[{"award-number":["511"]}],"id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alzheimer's Research UK","award":["ARUK-PG2019B-020"],"award-info":[{"award-number":["ARUK-PG2019B-020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2024,6,27]]},"DOI":"10.1021\/acs.jmedchem.3c02408","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T15:48:46Z","timestamp":1717688926000},"page":"9857-9868","source":"Crossref","is-referenced-by-count":9,"title":["A Potent Sybody Selectively Inhibits \u03b1-Synuclein Amyloid Formation by Binding to the P1 Region"],"prefix":"10.1021","volume":"67","author":[{"given":"Dimitra","family":"Gialama","sequence":"first","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-0089","authenticated-orcid":true,"given":"Devkee M.","family":"Vadukul","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Thrush","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K."},{"name":"Institute of Chemical Biology, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3079-8039","authenticated-orcid":true,"given":"Sheena E.","family":"Radford","sequence":"additional","affiliation":[{"name":"Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-4420","authenticated-orcid":true,"given":"Francesco A.","family":"Aprile","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K."},{"name":"Institute of Chemical Biology, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-082721-024500"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1093\/abt\/tbac005"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3390\/antib8030044"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-018-0133-0"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700407114"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121966119"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34317"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092677"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919464117"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1700488"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807884115"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-179005"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.023"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14810"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a024091"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.9443"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/bip.10179"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01146-6"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0384-x"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29724-4"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32687-1"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c02262"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.696440"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.46112"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC00066K"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-02886-y"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-023-01512-w"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00813-8"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054367"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0187-4"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.870517"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00523K"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-020-00226-z"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00410-0"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-020-0304-x"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp027"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/bi200178z"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1110\/ps.34602"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1039\/C8CP05904G"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21937-3"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1315346111"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2023.102579"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2019.10.002"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041293"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-020-0505-6"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.08.013"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.12.011"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.0c03260"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-584-7:531"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421204112"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604645113"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-57143-x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15174"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.3c02408","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.3c02408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T08:58:25Z","timestamp":1719478705000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.3c02408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,6,27]]}},"alternative-id":["10.1021\/acs.jmedchem.3c02408"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.3c02408","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]}}}