{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:43:00Z","timestamp":1782783780211,"version":"3.54.5"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"5","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2025,3,13]]},"DOI":"10.1021\/acs.jmedchem.4c02090","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T16:50:48Z","timestamp":1732207848000},"page":"5152-5169","source":"Crossref","is-referenced-by-count":7,"title":["Discovery of GS-2278, a Potent and Selective LPAR1 Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis"],"prefix":"10.1021","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-7811","authenticated-orcid":true,"given":"Doris T.","family":"Tang","sequence":"first","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Du","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin S.","family":"Yang","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Bestvater","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Neubig","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8621-2973","authenticated-orcid":true,"given":"Casey L.","family":"Olen","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Phillips","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3618-4641","authenticated-orcid":true,"given":"Thomas","family":"Hudson","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Marchand","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Chan","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Sharma","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiding","family":"Hu","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Matles","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Nejati","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Chojnacka","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton","family":"Adams","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie","family":"Pong","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Holsapple","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Budas","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vickie","family":"Tsui","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrasekar","family":"Venkataramani","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Lazerwith","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Notte","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"McGlinchey","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3641-7936","authenticated-orcid":true,"given":"Anna","family":"Zagorska","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-4328","authenticated-orcid":true,"given":"Julie","family":"Farand","sequence":"additional","affiliation":[{"name":"Gilead Sciences Inc., 333 Lakeside Drive, Foster City, California 94404, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705751"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402582"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402584"},{"key":"ref4\/cit4","volume-title":"Respiratory Medicine","author":"Meyer K. C.","year":"2019"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0155OC"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.04.084"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/nm1685"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00828.x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.08.1058"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01256"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","unstructured":"Gill, M. W.; Lakshmi, S.; Cheng, P. T. W.; Murphy, B. J.; Chadwick, K.; Lehman-McKeeman, L.; Graziano, M. BMS-986278, an LPA1 Receptor Antagonist for Idiopathic Pulmonary Fibrosis: Preclinical Assessments of Potential Hepatobiliary Toxicity [Abstract]. In  American Thoracic Society International Conference (ATS), Dallas, TX, 17\u201322 May, 2019.","DOI":"10.1164\/ajrccm-conference.2019.199.1_MeetingAbstracts.A5882"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2021-001026"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202405-0977OC"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","unstructured":"Tan, C.; Zhang, J.; Hu, Z.; Chen, L.; Guan, Z.; Xu, Z.; Mao, T.; Zhang, H.; Zhang, F.; Jiang, X.;  Structure Based Discovery and Anti-Fibrotic Activity of Novel Antagonists of Lysophosphatidic Acid Receptor 1 (LPAR1). [Poster 7223]. In American Thoracic Society (ATS): Washington, DC, May 19\u201324, 2023.","DOI":"10.1164\/ajrccm-conference.2023.207.1_MeetingAbstracts.A2253"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01827"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121723"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.002"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0050OC"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.12.005"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00302.2019"},{"key":"ref22\/cit22","unstructured":"Cheng, P. T. W.; Kaltenbach, F., III; Shi, J.; Shi, Y.; Zhang, H. Preparation of Cyclopentyl Acids as LPA Antagonists. WO2020\/060915A1, 2020."},{"key":"ref23\/cit23","unstructured":"Cheng, P. T. W.; Kaltenbach, R. F., III; Li, J.; Shi, J.; Shi, Y.; Tao, S.; Zhang, H.; Dhanusu, S.; Selvakumar, K.; Reddigunta, R. B.; Walker, S. J.; Kennedy, L. J.; Corte, J. R.; Fang, T.; Jusuf, S. Carbamoyloxymethyl Triazole Cyclohexyl Acids as LPA Antagonists and their Preparation. US2017\/0360759Al, 2017."},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.4c00369"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.175901"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FPJ05030X"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.2174\/1872312813666190311125652"},{"key":"ref27\/cit27","unstructured":"U.S. Food and Drug Administration. https:\/\/www.fda.gov\/media\/72309\/download (accessed Oct 4, 2024)."},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.3727\/000000003108747064"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.74101"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.4c02090","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.4c02090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T08:30:33Z","timestamp":1741854633000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.4c02090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3,13]]}},"alternative-id":["10.1021\/acs.jmedchem.4c02090"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.4c02090","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,21]]}}}