{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T06:35:18Z","timestamp":1775716518717,"version":"3.50.1"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["TM202101H006"],"award-info":[{"award-number":["TM202101H006"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["TM202101H012"],"award-info":[{"award-number":["TM202101H012"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012247","name":"Program of Shanghai Academic Research Leader","doi-asserted-by":"publisher","award":["22XD1404400"],"award-info":[{"award-number":["22XD1404400"]}],"id":[{"id":"10.13039\/501100012247","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Laboratory Program","award":["SYS202205"],"award-info":[{"award-number":["SYS202205"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2025,2,27]]},"DOI":"10.1021\/acs.jmedchem.4c02232","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T12:20:56Z","timestamp":1738930856000},"page":"4382-4396","source":"Crossref","is-referenced-by-count":2,"title":["Development of ASGR-Mediated Hepatocyte-Targeting Cytotoxic Drug Conjugates with CTSB-Cleavable Linkers Incorporating Succinimide and Succinic Acid Monoamide"],"prefix":"10.1021","volume":"68","author":[{"given":"Jingsheng","family":"Jiang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3806-0230","authenticated-orcid":true,"given":"Sigang","family":"Jian","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology","place":["Shanghai, China"]},{"name":"Shanghai Tech University","place":["Shanghai, China"]},{"name":"State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica","place":["Shanghai, China"]},{"name":"Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"School of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica","place":["Shanghai, China"]},{"name":"Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guozhang","family":"Long","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"},{"name":"Xinjiang Technical Institute of Physics and Chemistry","place":["Urumqi, China"]},{"name":"Chinese Academy of Sciences","place":["Urumqi, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biyu","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica","place":["Shanghai, China"]},{"name":"Chinese Academy of Sciences","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junzhen","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfen","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"School of Life Science and Technology","place":["Shanghai, China"]},{"name":"Shanghai Tech University","place":["Shanghai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"School of Life Science and Technology","place":["Shanghai, China"]},{"name":"Shanghai Tech University","place":["Shanghai, China"]},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"},{"name":"Shandong Laboratory of Yantai Drug Discovery","place":["Yantai, China"]},{"name":"Bohai Rim Advanced Research Institute for Drug Discovery","place":["Yantai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8167-9750","authenticated-orcid":true,"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"},{"name":"School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, First Xiangshan Branch Alley, Hangzhou 310024, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"},{"name":"State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica","place":["Shanghai, China"]},{"name":"Chinese Academy of Sciences","place":["Shanghai, China"]},{"name":"Shandong Laboratory of Yantai Drug Discovery","place":["Yantai, China"]},{"name":"Bohai Rim Advanced Research Institute for Drug Discovery","place":["Yantai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1770-6272","authenticated-orcid":true,"given":"Youhong","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-ChongZhi Road, Shanghai 201203, China"},{"name":"University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China"},{"name":"School of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, No. 138 Xianlin Road, Nanjing 210023, China"},{"name":"School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, First Xiangshan Branch Alley, Hangzhou 310024, China"},{"name":"Shandong Laboratory of Yantai Drug Discovery","place":["Yantai, China"]},{"name":"Bohai Rim Advanced Research Institute for Drug Discovery","place":["Yantai, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.10.078"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-018-0065-8"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-021-02707-5"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-017-0484-7"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.02.022"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00651"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.31.19502"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2016.12.003"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c01755"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.202013243"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2019.1621838"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00042"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.0c00202"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.12.032"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.06.002"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00980"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100158"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01365"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c01135"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0488"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814017"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01834-3"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.12.002"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00676H"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2968"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/bc5005262"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-018-0209-2"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2015.09.032"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/bc500357n"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201609733"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03721"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01579"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01948"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00432"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/jp512991d"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80319-X"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-1004"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01430"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04982-3"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.4c02232","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.4c02232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T09:57:53Z","timestamp":1740650273000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.4c02232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2,27]]}},"alternative-id":["10.1021\/acs.jmedchem.4c02232"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.4c02232","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]}}}