{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:39:35Z","timestamp":1788925175541,"version":"build-2803163510"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"10","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Southern Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2025,5,22]]},"DOI":"10.1021\/acs.jmedchem.4c02473","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T09:54:36Z","timestamp":1747043676000},"page":"9926-9946","source":"Crossref","is-referenced-by-count":3,"title":["Discovery of a Chiral 2,4-Substituted Pyrrolo[2,3-<i>d<\/i>]pyrimidine as a Potent, Selective, and Orally Bioavailable LRRK2 Inhibitor"],"prefix":"10.1021","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-1643","authenticated-orcid":true,"given":"Omar","family":"Moukha-Chafiq","sequence":"first","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuyana","family":"Malankhanova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology","place":["Durham, United States"]},{"name":"Duke University School of Medicine","place":["Durham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Valiyaveettil","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Gupta","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hollis","family":"Kezar","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]},{"name":"System Pharmacology AI Research Center, Heersink School of Medicine","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuklendu","family":"Karyakarte","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumendranath","family":"Bhakat","sequence":"additional","affiliation":[{"name":"System Pharmacology AI Research Center, Heersink School of Medicine","place":["Birmingham, United States"]},{"name":"University of Alabama at Birmingham","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Galemmo","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Ananthan","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Manuvakhova","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry I.","family":"Ross","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Maddry","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bostwick","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Suto","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"West","sequence":"additional","affiliation":[{"name":"Department of Pharmacology","place":["Durham, United States"]},{"name":"Duke University School of Medicine","place":["Durham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7676-6120","authenticated-orcid":true,"given":"Corinne E.","family":"Augelli-Szafran","sequence":"additional","affiliation":[{"name":"Scientific Platforms Division","place":["Birmingham, United States"]},{"name":"Southern Research","place":["Birmingham, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"ref2\/cit2","volume-title":"Statistics on Parkinson\u2019s; Parkinson\u2019s Disease Foundation","year":"2021"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.189"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2008.10.005"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.11.005"},{"key":"ref6\/cit6a","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0218-1"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26354"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14182"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1666-18.2018"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1159\/000488938"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.03.045"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.07.019"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-49969-7_12"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2017.1323881"},{"key":"ref14\/cit14","first-page":"37","volume-title":"Progress in Medicinal Chemistry","volume":"56","author":"Christensen K. V.","year":"2017"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2017.1280464"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00045"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.07.052"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.07.072"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666151030102847"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.04.021"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00261"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/jm5014055"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.227587"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/jm401654j"},{"key":"ref25\/cit25a","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2012.729041"},{"key":"ref25\/cit25b","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2014.907275"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.05.054"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.041"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.02.043"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/jm301020q"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.538"},{"key":"ref31\/cit31","unstructured":"Denali Therapeutics. Our\npipeline Denali | Pipeline denalitherapeutics.com (2024)."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.602318"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115475"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00252-y"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112290"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00738-4"},{"key":"ref37\/cit37","unstructured":"Augelli-Szafran, C. E.; Suto, M.; Galemmo, R.; Moukha-Chafiq, O.; Gupta, V.; Ananthan, S. Pyrrolopyrimidine Compounds, Uses as Inhibitors of the Kinase LRRK2, and Methods for Preparation Thereof. Issued US Patent: US10,023,579B2, July, 2018. WO2017\/106771A1, June 22, 2017."},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1002\/prot.24551"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.5b00064"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jm050540c"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ac9912247"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.01.071"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1177\/1087057108323911"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.4c02473","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.4c02473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:13:12Z","timestamp":1747901592000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.4c02473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,5,22]]}},"alternative-id":["10.1021\/acs.jmedchem.4c02473"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.4c02473","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]}}}