{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:39:08Z","timestamp":1787315948075,"version":"build-2736575974"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["BK20230251"],"award-info":[{"award-number":["BK20230251"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["tstp20240852"],"award-info":[{"award-number":["tstp20240852"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Department of Science and Technology of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH243"],"award-info":[{"award-number":["ZR2022MH243"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Department of Science and Technology of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023LZY008"],"award-info":[{"award-number":["ZR2023LZY008"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Department of Science and Technology of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024LMB016"],"award-info":[{"award-number":["ZR2024LMB016"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Collaborative Academic Innovation Project of Shandong Cancer Hospital","award":["ZF003"],"award-info":[{"award-number":["ZF003"]}]},{"name":"Shandong Province Traditional Chinese Medicine Science and Technology Project","award":["Z20243904"],"award-info":[{"award-number":["Z20243904"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2026,1,22]]},"DOI":"10.1021\/acs.jmedchem.5c02112","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:29:18Z","timestamp":1767929358000},"page":"982-1003","source":"Crossref","is-referenced-by-count":2,"title":["First-in-Class Quinoline-Dione-Derived PROTACs: Potent Degraders of Cdc25 Phosphatases for Antitumor Therapy"],"prefix":"10.1021","volume":"69","author":[{"given":"Guanyu","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (Shandong Provincial Key Traditional Chinese Medical Discipline of Clinical Chinese Pharmacy)","place":["Jinan, P. R. China"]},{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (Shandong Provincial Key Traditional Chinese Medical Discipline of Clinical Chinese Pharmacy)","place":["Jinan, P. R. China"]},{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjiao","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (Shandong Provincial Key Traditional Chinese Medical Discipline of Clinical Chinese Pharmacy)","place":["Jinan, P. R. China"]},{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-6026","authenticated-orcid":true,"given":"Peng","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, Jinan, Shandong 250012, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (Shandong Provincial Key Traditional Chinese Medical Discipline of Clinical Chinese Pharmacy)","place":["Jinan, P. R. China"]},{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-0143","authenticated-orcid":true,"given":"Chuanfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy (Shandong Provincial Key Traditional Chinese Medical Discipline of Clinical Chinese Pharmacy)","place":["Jinan, P. R. China"]},{"name":"Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences","place":["Jinan, P. R. China"]},{"name":"Suzhou Research Institute of Shandong University, Room607, Building B of NUSP, NO.388 Ruoshui Road, SIP, Suzhou, Jiangsu 215123, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuning","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pharmacy","place":["Jinan, P. R. China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.07.001"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.02.003"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1021\/jm200607g"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1126\/science.7667636"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2004.07.007"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5139"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.9.6183"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06417.x"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01304-w"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(01)00669-3"},{"issue":"18","key":"ref11\/cit11","first-page":"4082","volume":"58","author":"Wu W.","year":"1998","journal-title":"Cancer Res."},{"issue":"11","key":"ref12\/cit12","first-page":"3043","volume":"60","author":"Takemasa I.","year":"2000","journal-title":"Cancer Res."},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780254"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9174"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-0146-5"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1007\/BF02984552"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1997.tb00313.x"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.029546"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.03.039"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.05.063"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.2174\/1389557520666200619182519"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073714"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/prot.25236"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3892\/etm_00000101"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.09.023"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111696"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105254"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407663101"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22420"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.42.083001.144616"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.08.010"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60107-7"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00408"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01827"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.872729"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c00970"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2025.108437"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01719"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-024-02023-7"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118470"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118215"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2021.1983280"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.12.042"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.5c02112","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.5c02112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:15:25Z","timestamp":1769073325000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.5c02112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,8]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,22]]}},"alternative-id":["10.1021\/acs.jmedchem.5c02112"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c02112","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,8]]}}}