{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:08:57Z","timestamp":1784815737812,"version":"3.55.0"},"reference-count":72,"publisher":"American Chemical Society (ACS)","issue":"14","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["RO1CA069202"],"award-info":[{"award-number":["RO1CA069202"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2026,7,23]]},"DOI":"10.1021\/acs.jmedchem.5c03467","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:14:47Z","timestamp":1782980087000},"page":"16401-16427","source":"Crossref","is-referenced-by-count":0,"title":["A Potent and Selective Quinolone-Based PTPN22 Inhibitor with Improved Immunotherapeutic Activity"],"prefix":"10.1021","volume":"69","author":[{"given":"Jianping","family":"Lin","sequence":"first","affiliation":[{"name":"Borch Department of Medicinal Chemistry and Molecular Pharmacology","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenson A.","family":"Jassim","sequence":"additional","affiliation":[{"name":"Borch Department of Medicinal Chemistry and Molecular Pharmacology","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Bai","sequence":"additional","affiliation":[{"name":"Borch Department of Medicinal Chemistry and Molecular Pharmacology","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Qu","sequence":"additional","affiliation":[{"name":"The James Tarpo Jr. and Margaret Tarpo Department of Chemistry","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Nguele Meke","sequence":"additional","affiliation":[{"name":"Borch Department of Medicinal Chemistry and Molecular Pharmacology","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Dong","sequence":"additional","affiliation":[{"name":"Borch Department of Medicinal Chemistry and Molecular Pharmacology","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Drug Discovery","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8188-9056","authenticated-orcid":true,"given":"Benjamin","family":"Babalola","sequence":"additional","affiliation":[{"name":"The James Tarpo Jr. and Margaret Tarpo Department of Chemistry","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1826-6902","authenticated-orcid":true,"given":"Jingmei","family":"Yu","sequence":"additional","affiliation":[{"name":"Borch Department of Medicinal Chemistry and Molecular Pharmacology","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Zhang","sequence":"additional","affiliation":[{"name":"Borch Department of Medicinal Chemistry and Molecular Pharmacology","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5527-7910","authenticated-orcid":true,"given":"Zhong-Yin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Borch Department of Medicinal Chemistry and Molecular Pharmacology","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]},{"name":"The James Tarpo Jr. and Margaret Tarpo Department of Chemistry","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]},{"name":"Institute for Drug Discovery","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]},{"name":"Institute for Cancer Research","place":["West Lafayette, United States"]},{"name":"Purdue University","place":["West Lafayette, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.174"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.30856"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2021.153723"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21596"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0300-z"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666190308131805"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800991"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00538-9"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-022-00618-w"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16304"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.80"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2039"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00195-4"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00537"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120249"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600498200"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072384"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00376"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/ng.904"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600604"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45790"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aaf7153"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003365"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200150"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.6.2013.406k25_2013_2024"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/ng1323"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1086\/422827"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127847"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001439"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146950"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66963"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092138"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100304"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2022.2084607"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.117129"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115599"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706233104"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/jm101202j"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.916"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/jm500692u"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.007129"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104124"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/jm400248c"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb803"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1528"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nature18621"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/bi00174a040"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1126\/science.7540771"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2265"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.42.083001.144616"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13420"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106568200"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1021\/bi9813781"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909133107"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/jm901645u"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/jm301781p"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5463"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/jm5006176"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2011.11.007"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/jm101356p"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01215"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-023-02804-5"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00258"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.0c00553"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00002"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/med.21562"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.77"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1021\/jm030266r"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku316"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.4155\/tde.11.19"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00993"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01648"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.5c03467","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.5c03467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:43:56Z","timestamp":1784814236000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.5c03467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":72,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7,23]]}},"alternative-id":["10.1021\/acs.jmedchem.5c03467"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c03467","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]}}}