{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:06:22Z","timestamp":1792267582146,"version":"4.4.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010057","name":"University of Winchester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2020,3,26]]},"DOI":"10.1021\/acs.jmedchem.9b02090","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T18:02:27Z","timestamp":1581098547000},"page":"3317-3326","source":"Crossref","is-referenced-by-count":61,"title":["Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action"],"prefix":"10.1021","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0589-3955","authenticated-orcid":true,"given":"Mohamed","family":"Fares","sequence":"first","affiliation":[{"name":"School of Chemistry & Molecular Bioscience, Molecular Horizons, and Illawarra Health & Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia"},{"name":"School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagdy M.","family":"Eldehna","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh 33516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bua","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Lanzi","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Gaetano Pieraccini 6, 50100 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lucarini","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Gaetano Pieraccini 6, 50100 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Masini","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale Gaetano Pieraccini 6, 50100 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Peat","sequence":"additional","affiliation":[{"name":"Biomedical Manufacturing Program, CSIRO, 343 Royal Parade, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem A.","family":"Abdel-Aziz","sequence":"additional","affiliation":[{"name":"Department of Applied Organic Chemistry, National Research Center, Dokki, Giza 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-702X","authenticated-orcid":true,"given":"Alessio","family":"Nocentini","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4868-845X","authenticated-orcid":true,"given":"Paul A.","family":"Keller","sequence":"additional","affiliation":[{"name":"School of Chemistry & Molecular Bioscience, Molecular Horizons, and Illawarra Health & Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":true,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via Ugo Schiff 6, Sesto Fiorentino, 50019 Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00828"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.67"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.081224"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.01.030"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.672983"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.07.073"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1021\/jm501497m"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01389"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.11.014"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00625"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1021\/jm501798g"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.04.016"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.02.037"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/jm9901879"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1021\/jm9900523"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.016"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.12.004"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/jo01258a039"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1002\/1099-0690(200205)2002:10<1654::AID-EJOC1654>3.0.CO;2-U","volume":"10","author":"Frohberg P.","year":"2002","journal-title":"Eur. J. Org. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21010114"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","volume":"246","author":"Khalifah R. G.","year":"1971","journal-title":"J. Biol. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1002\/chin.197951258"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ml400226s"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909047337"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1107\/S090744491003982X"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889807021206"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444911001314"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201800941"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.02.021"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201805039"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1512597"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.4103\/0976-500X.72351"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jmedchem.9b02090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T22:59:22Z","timestamp":1681685962000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.9b02090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,3,26]]}},"alternative-id":["10.1021\/acs.jmedchem.9b02090"],"URL":"https:\/\/doi.org\/10.1021\/acs.jmedchem.9b02090","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,7]]}}}