{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:48:54Z","timestamp":1791431334527,"version":"4.3.3"},"reference-count":37,"publisher":"American Chemical Society (ACS)","issue":"12","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog?a","doi-asserted-by":"publisher","award":["221136"],"award-info":[{"award-number":["221136"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog?a","doi-asserted-by":"publisher","award":["CVU 103584"],"award-info":[{"award-number":["CVU 103584"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2020,12,24]]},"DOI":"10.1021\/acs.jnatprod.0c00892","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T04:34:42Z","timestamp":1606278882000},"page":"3671-3680","source":"Crossref","is-referenced-by-count":15,"title":["Linearolactone and Kaempferol Disrupt the Actin Cytoskeleton in <i>Entamoeba histolytica<\/i>: Inhibition of Amoebic Liver Abscess Development"],"prefix":"10.1021","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4504-8166","authenticated-orcid":true,"given":"Jos\u00e9 Antonio","family":"Vel\u00e1zquez-Dom\u00ednguez","sequence":"first","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, CINVESTAV-IPN, Av. IPN 2508, San Pedro Zacatenco, 07360, CDMX, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-939X","authenticated-orcid":true,"given":"Ver\u00f3nica Ivonne","family":"Hern\u00e1ndez-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, CINVESTAV-IPN, Av. IPN 2508, San Pedro Zacatenco, 07360, CDMX, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-5988","authenticated-orcid":true,"given":"Fernando","family":"Calzada","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Farmacolog\u00eda, UMAE Hospital de Especialidades, CMN-Siglo XXI, Av. Cuauht\u00e9moc 330, Col. Doctores, 06720, CDMX, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-8403","authenticated-orcid":true,"given":"Luis","family":"Varela-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, CINVESTAV-IPN, Av. IPN 2508, San Pedro Zacatenco, 07360, CDMX, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-0351","authenticated-orcid":true,"given":"Diana L.","family":"Pichardo-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, CINVESTAV-IPN, Av. IPN 2508, San Pedro Zacatenco, 07360, CDMX, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-9182","authenticated-orcid":true,"given":"Elih\u00fa","family":"Bautista","sequence":"additional","affiliation":[{"name":"Unidad de Ciencias Ambientales, IPICYT, Camino a la Presa San Jos\u00e9, No. 2055, Lomas 4a. Secci\u00f3n, 78216, San Luis Potos\u00ed, S.L.P., M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra","family":"Herrera-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Farmacobiolog\u00eda, Universidad de la Ca\u00f1ada, Carretera Teotitl\u00e1n San Antonio Nanahuatip\u00e1n\rKm 1.7 s\/n. Paraje Titlacuatitla, 68540, Teotitl\u00e1n de Flores Mag\u00f3n, Oax., M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8050-2451","authenticated-orcid":true,"given":"Rodrigo D.","family":"Castellanos-Mijangos","sequence":"additional","affiliation":[{"name":"Servicio de Imagenolog\u00eda Diagn\u00f3stica, Centro M\u00e9dico ISSEMyM \u201cArturo Montiel Rojas\u201d, Av. Baja Velocidad No. 284, Carretera M\u00e9xico-Toluca\rKm. 57.5, San Jer\u00f3nimo Chicahualco, 52170, Metepec, Edo. M\u00e9x., M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2987-7119","authenticated-orcid":true,"given":"Audifas Salvador","family":"Matus-Meza","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, 04510, Mexico City, CDMX, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7765-3814","authenticated-orcid":true,"given":"Bibiana","family":"Ch\u00e1vez-Mungu\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, CINVESTAV-IPN, Av. IPN 2508, San Pedro Zacatenco, 07360, CDMX, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5085-814X","authenticated-orcid":true,"given":"Patricia","family":"Talam\u00e1s-Rohana","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular, CINVESTAV-IPN, Av. IPN 2508, San Pedro Zacatenco, 07360, CDMX, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.37.26051"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5421"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2938"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2015.11.004"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fphar.2016.00169","volume":"7","author":"Herrera-Mart\u00ednez M.","year":"2016","journal-title":"Front Pharmacol."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00209"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)81700-8"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00591"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1717"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.09.009"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112676"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.08.015"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009616228304"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20130282"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.01.001"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.09.007"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-019-2566-9"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146287"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1055\/a-1111-9566"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2006.03.005"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1730452"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8040172"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004340"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.107.107813"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182012001540"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13173"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.12.007"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.03.028"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.10.001"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b14-00239"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(99)00466-5"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1111\/jeu.12321"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.04.023"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1177\/026119290303100204"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.0c00892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T11:47:34Z","timestamp":1682509654000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.0c00892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,24]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12,24]]}},"alternative-id":["10.1021\/acs.jnatprod.0c00892"],"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.0c00892","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,24]]}}}