{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T14:26:43Z","timestamp":1783780003045,"version":"3.55.0"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN261200800001E"],"award-info":[{"award-number":["HHSN261200800001E"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2024,2,23]]},"DOI":"10.1021\/acs.jnatprod.3c01113","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T06:42:47Z","timestamp":1706683367000},"page":"415-423","source":"Crossref","is-referenced-by-count":8,"title":["Formation of Trideuteromethylated Artifacts of Pyrrole-Containing Natural Products"],"prefix":"10.1021","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-7645","authenticated-orcid":true,"given":"Maria","family":"Orfanoudaki","sequence":"first","affiliation":[{"name":"Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhone K.","family":"Akee","sequence":"additional","affiliation":[{"name":"Natural Products Support Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucero","family":"Mart\u00ednez-Fructuoso","sequence":"additional","affiliation":[{"name":"Natural Products Branch, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-2507","authenticated-orcid":true,"given":"Dongdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis J.","family":"Henrich","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States"},{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0503-0116","authenticated-orcid":true,"given":"Martin J.","family":"Schnermann","sequence":"additional","affiliation":[{"name":"Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-4856","authenticated-orcid":true,"given":"Barry R.","family":"O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States"},{"name":"Natural Products Branch, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6537-3997","authenticated-orcid":true,"given":"Tanja","family":"Grkovic","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States"},{"name":"Natural Products Branch, Developmental Therapeutic Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501100b"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60015G"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/7081_019","volume-title":"Heterocyclic Antitumor Antibiotics","author":"Gupton J. T.","year":"2006"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.29356\/jmcs.v60i1.67"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/D0QO01574A"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.3390\/md8051526"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/bs.alkal.2019.10.001"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00024"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19920750525"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/jo00084a015"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ol702952n"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/ja00971a040"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(98)02467-8"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)86737-5"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jo00015a005"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.8b00343"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2004.06.015"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201800235"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27248724"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/cr100435g"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.3390\/md16070241"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1021\/np100443c"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/np0303761"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/b407299p"},{"key":"ref25\/cit25","volume-title":"NMR Spectroscopy - Basic Principles, Concepts, and Applications in Chemistry","author":"G\u00fcnther H.","year":"2013"},{"key":"ref26\/cit26","volume-title":"Spectrometric Identification of Organic Compounds","author":"Silverstein R. M.","year":"2005","edition":"7"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/np0600090"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/np400296s"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c00198"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201005883"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2017.02.018"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB01490J"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA08484F"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201303802"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202101179"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1911883116"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jo00240a025"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2009.06.109"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.12.081"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/np010581l"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430340203"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0605"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1951"},{"key":"ref44\/cit44","unstructured":"https:\/\/dtp.cancer.gov\/. (accessed\n2023 09\/19\/2023)."},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12849"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.3390\/md18080404"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202100155"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2012.02.052"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/jo00105a047"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.3390\/md21090474"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0103-2"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0702"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-93097-9"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15074526"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1021\/jo801622n"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1166\/jctn.2011.1794"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1338"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c03922"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2015.09.073"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b01723"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC00781B"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113378"},{"key":"ref63\/cit63","unstructured":"https:\/\/hpc.nih.gov\/systems\/ (accessed 12\/18\/2023)."}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.3c01113","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.3c01113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T09:30:38Z","timestamp":1708680638000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.3c01113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,23]]}},"alternative-id":["10.1021\/acs.jnatprod.3c01113"],"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.3c01113","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]}}}