{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:27:34Z","timestamp":1792816054044,"version":"4.5.0"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012012","name":"Kanamori Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012012","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JST SPRING","award":["JPMJSP2145"],"award-info":[{"award-number":["JPMJSP2145"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2024,11,22]]},"DOI":"10.1021\/acs.jnatprod.4c00812","type":"journal-article","created":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T09:55:26Z","timestamp":1730022926000},"page":"2604-2614","source":"Crossref","is-referenced-by-count":12,"title":["Divergent Total Synthesis of Isoflavone Natural Products and Their Potential as Therapeutic Agents for TTR Amyloidosis"],"prefix":"10.1021","volume":"87","author":[{"given":"Nguyen Ngoc","family":"Thanh Luan","sequence":"first","affiliation":[{"name":"Graduate School of Innovative Life Science, University of Toyama, Toyama 930-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-7711","authenticated-orcid":true,"given":"Takuya","family":"Okada","sequence":"additional","affiliation":[{"name":"Graduate School of Innovative Life Science, University of Toyama, Toyama 930-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5362-8606","authenticated-orcid":true,"given":"Takeshi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Toyama, Toyama 930-0914, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mie","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Nabeshima","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Toyama, Toyama 930-0914, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-0339","authenticated-orcid":true,"given":"Mineyuki","family":"Mizuguchi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Toyama, Toyama 930-0914, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9568-1528","authenticated-orcid":true,"given":"Naoki","family":"Toyooka","sequence":"additional","affiliation":[{"name":"Graduate School of Innovative Life Science, University of Toyama, Toyama 930-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,10,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djj102"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(12)60033-9"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.6133\/apjcn.2013.22.1.16"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202201136"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2022.132931"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.8b00321"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2004.03.006"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/np100896w"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2014.02.001"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00216"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201201339"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.07.023"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-31"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1186\/2047-9158-3-19"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/bi00151a036"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/bi952501g"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121005109"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10787"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2019.1597702"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300761110"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.03.012"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126526"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116292"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00511"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2023.117370"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16915"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02286"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00934"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/srep13570"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.12.050"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.8b01034"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.3c00292"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.01.040"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2022.2125966"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(89)80140-2"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)98025-7"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(92)80060-R"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/np100407n"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2014.06.002"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c02698"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/ph17010086"}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.4c00812","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.4c00812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:57:35Z","timestamp":1732251455000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.4c00812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,27]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11,22]]}},"alternative-id":["10.1021\/acs.jnatprod.4c00812"],"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.4c00812","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,27]]}}}