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Their structures were elucidated by spectroscopic methods and HRESITOFMS data. Compounds 5, 13, 15, 16, 22, and 30 inhibited nitric oxide (NO) production with IC50 values ranging from 8.7 \u00b1 0.1 to 17 \u00b1 1 \u03bcM, revealing stronger effects than the standard drug, dexamethasone (IC50 16.9 \u00b1 2.2 \u03bcM), and compound 30 possessed the most potent NO production inhibition. Compounds 12 and 29 demonstrated notable efficacy in enhancing glucose consumption with IC50 values of 77 \u00b1 4 and 66 \u00b1 4 \u03bcM, respectively, while their glucose uptakes were 1.7- and 2-fold, respectively.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.4c00933","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T09:50:51Z","timestamp":1730973051000},"page":"1549-1556","source":"Crossref","is-referenced-by-count":0,"title":["Alkaloids and\nStyryl Lactones from\n                    <i>Goniothalamus tortilipetalus<\/i>\n                    and Their Biological Activities"],"prefix":"10.1021","volume":"88","author":[{"given":"Sorraya","family":"Champakam","sequence":"first","affiliation":[{"name":"Mae Fah Luang University , , , ,","place":["Chiang Rai, Thailand, 57100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-8439","authenticated-orcid":true,"given":"Brian O.","family":"Patrick","sequence":"additional","affiliation":[{"name":"University of British Columbia , , 2036 Main Mall , , ,","place":["Vancouver, BC, Canada, V6T 1Z1"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natcha","family":"Injan","sequence":"additional","affiliation":[{"name":"University of Phayao , , ,","place":["Phayao, Thailand, 56000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somkiat","family":"Nokbin","sequence":"additional","affiliation":[{"name":"Kasetsart University , , ,","place":["Bangkok, Thailand, 10900"]},{"name":"Kasetsart University , , ,","place":["Bangkok, Thailand, 10900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4333-1059","authenticated-orcid":true,"given":"Sarot","family":"Cheenpracha","sequence":"additional","affiliation":[{"name":"University of Phayao , , ,","place":["Phayao, Thailand, 56000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2437-6526","authenticated-orcid":true,"given":"Zi Han","family":"Loh","sequence":"additional","affiliation":[{"name":"Taylor\u2019s University , , Lakeside Campus , , Subang Jaya, ,","place":["Selangor, Malaysia, 47500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharakorn","family":"Maneerat","sequence":"additional","affiliation":[{"name":"Medicinal Plants Innovation Center of Mae Fah Luang University , , ,","place":["Chiang Rai, Thailand, 57100"]},{"name":"Mae Fah Luang University , , , ,","place":["Chiang Rai, Thailand, 57100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panom","family":"Winyayong","sequence":"additional","affiliation":[{"name":"Mae Fah Luang University , , , ,","place":["Chiang Rai, Thailand, 57100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phunrawie","family":"Promnart","sequence":"additional","affiliation":[{"name":"Mae Fah Luang University , , , ,","place":["Chiang Rai, Thailand, 57100"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0370-4866","authenticated-orcid":true,"given":"Siau Hui","family":"Mah","sequence":"additional","affiliation":[{"name":"Taylor\u2019s University , , Lakeside Campus , , Subang Jaya, ,","place":["Selangor, Malaysia, 47500"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7607-8213","authenticated-orcid":true,"given":"Raymond J.","family":"Andersen","sequence":"additional","affiliation":[{"name":"University of British Columbia , , 2036 Main Mall , , ,","place":["Vancouver, BC, Canada, V6T 1Z1"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-2781","authenticated-orcid":true,"given":"Surat","family":"Laphookhieo","sequence":"additional","affiliation":[{"name":"Mae Fah Luang University , , , ,","place":["Chiang Rai, Thailand, 57100"]},{"name":"Medicinal Plants Innovation Center of Mae Fah Luang University , , ,","place":["Chiang Rai, Thailand, 57100"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"2026090715154460500_cit1","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1095-8339.2007.00762.x","volume":"156","author":"Sauders","year":"2008","journal-title":"Bot. 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