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While vaccines are under development, there are currently no therapies to treat this disease, except for over-the-counter (OTC) analgesics, which alleviate the devastating arthritic and arthralgic symptoms. To identify novel inhibitors of the virus, analogues of the natural product bryostatin 1, a clinical lead for the treatment of cancer, Alzheimer\u2019s disease, and HIV eradication, were investigated for in vitro antiviral activity and were found to be among the most potent inhibitors of CHIKV replication reported to date. Bryostatin-based therapeutic efforts and even recent anti-CHIKV strategies have centered on modulation of protein kinase C (PKC). Intriguingly, while the C ring of bryostatin primarily drives interactions with PKC, A- and B-ring functionality in these analogues has a significant effect on the observed cell-protective activity. Significantly, bryostatin 1 itself, a potent pan-PKC modulator, is inactive in these assays. These new findings indicate that the observed anti-CHIKV activity is not solely mediated by PKC modulation, suggesting possible as yet unidentified targets for CHIKV therapeutic intervention. The high potency and low toxicity of these bryologs make them promising new leads for the development of a CHIKV treatment.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.5b01016","type":"journal-article","created":{"date-parts":[[2016,2,22]],"date-time":"2016-02-22T10:36:41Z","timestamp":1456137401000},"page":"675-679","source":"Crossref","is-referenced-by-count":19,"title":["Simplified Bryostatin Analogues Protect Cells from\nChikungunya Virus-Induced Cell Death"],"prefix":"10.1021","volume":"79","author":[{"given":"Daryl","family":"Staveness","sequence":"first","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Abdelnabi","sequence":"additional","affiliation":[{"name":"KU Leuven\u2212University of Leuven , , ,","place":["Leuven, Belgium, B-3000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Schrier","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Loy","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal A.","family":"Verma","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"DeChristopher","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine E.","family":"Near","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[{"name":"KU Leuven\u2212University of Leuven , , ,","place":["Leuven, Belgium, B-3000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"Delang","sequence":"additional","affiliation":[{"name":"KU Leuven\u2212University of Leuven , , ,","place":["Leuven, Belgium, B-3000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Leyssen","sequence":"additional","affiliation":[{"name":"KU Leuven\u2212University of Leuven , , ,","place":["Leuven, Belgium, B-3000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Wender","sequence":"additional","affiliation":[{"name":"Stanford University , , , ,","place":["Stanford, California, United States, 94305"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,2,22]]},"reference":[{"key":"2026090308503115900_cit1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/B978-012072651-6\/50013-9","volume-title":"Anticancer\nDrug Development","author":"Pettit","year":"2002"},{"key":"2026090308503115900_cit2","doi-asserted-by":"publisher","first-page":"6846","DOI":"10.1021\/ja00388a092","volume":"104","author":"Pettit","year":"1982","journal-title":"J. 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