{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T05:18:39Z","timestamp":1773206319944,"version":"3.50.1"},"reference-count":26,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["NTU-CC-113L895203"],"award-info":[{"award-number":["NTU-CC-113L895203"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["NTU-CDP-113L7769"],"award-info":[{"award-number":["NTU-CDP-113L7769"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 113-2628-M-002-014-MY4"],"award-info":[{"award-number":["NSTC 113-2628-M-002-014-MY4"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2026,2,27]]},"DOI":"10.1021\/acs.jnatprod.5c01440","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T19:46:02Z","timestamp":1768506362000},"page":"639-644","source":"Crossref","is-referenced-by-count":0,"title":["Mechanistic Studies of the Calcium-Dependent Antibiotics via Cofactor Engineering"],"prefix":"10.1021","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5502-4966","authenticated-orcid":true,"given":"Shao-Lun","family":"Chiou","sequence":"first","affiliation":[{"name":"Department of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Rong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-7229","authenticated-orcid":true,"given":"John","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, National Taiwan University, No. 1 Section 4, Roosevelt Road, Taipei 10617, Taiwan"},{"name":"Center for Emerging Material and Advanced Devices","place":["Taipei, Taiwan"]},{"name":"National Taiwan University","place":["Taipei, Taiwan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"ref1\/cit1","first-page":"1239","volume":"3","author":"Heinemann B.","year":"1953","journal-title":"Antibiot. Chemother."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1039\/C9MD00126C"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202410286"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00219"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01040-08"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx349"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0110-1"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-129-12-3565"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.21.55"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.43.587"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12087"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-012-1107-x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317522"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/cr00002a004"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c03949"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC07190D"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201709240"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00810"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15257-1"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27082407"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b00043"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1139\/cjc-2024-0040"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/9781118794623.ch23"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9110729"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201709240"},{"key":"ref26\/cit26","first-page":"56","volume":"14","author":"Adedeji W. A.","year":"2016","journal-title":"Ann. Ib. Postgrad. Med."}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.5c01440","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.5c01440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:34:31Z","timestamp":1773128071000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.5c01440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2,27]]}},"alternative-id":["10.1021\/acs.jnatprod.5c01440"],"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.5c01440","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]}}}