{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:19:08Z","timestamp":1793445548529,"version":"4.5.0"},"reference-count":75,"publisher":"American Chemical Society (ACS)","issue":"1","funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001998"],"award-info":[{"award-number":["UL1 TR001998"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA016176"],"award-info":[{"award-number":["T32 DA016176"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"name":"College of Pharmacy, University of Kentucky"},{"DOI":"10.13039\/100015087","name":"Markey Cancer Center, University of Kentucky","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015087","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2017,1,27]]},"DOI":"10.1021\/acs.jnatprod.6b00948","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T18:40:13Z","timestamp":1482950413000},"page":"2-11","source":"Crossref","is-referenced-by-count":55,"title":["Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate <i>Streptomyces<\/i> sp. RM-14-6"],"prefix":"10.1021","volume":"80","author":[{"given":"Khaled A.","family":"Shaaban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith A.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Tran","sequence":"additional","affiliation":[{"name":"California Institute for Biomedical Research (Calibr), La Jolla, California 92037, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif I.","family":"Elshahawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa V.","family":"Ponomareva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiachang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory C.","family":"Copley","sequence":"additional","affiliation":[{"name":"Center\rfor Applied Energy Research, University of Kentucky, Lexington, Kentucky 40511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjula","family":"Sunkara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madan K.","family":"Kharel","sequence":"additional","affiliation":[{"name":"School\rof Pharmacy, University of Maryland Eastern Shore, Princess Anne, Maryland 21853, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-2776","authenticated-orcid":true,"given":"James C.","family":"Hower","sequence":"additional","affiliation":[{"name":"Center\rfor Applied Energy Research, University of Kentucky, Lexington, Kentucky 40511, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Tremblay","sequence":"additional","affiliation":[{"name":"California Institute for Biomedical Research (Calibr), La Jolla, California 92037, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Prendergast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7148-0721","authenticated-orcid":true,"given":"Jon S.","family":"Thorson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"ref1\/cit1","unstructured":"Laatsch, H.AntiBase 2014, The Natural Compound Identifier;Wiley-VCH:Weinheim, 2014."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2011.16"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2011.18"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2006.88"},{"key":"ref5\/cit5","unstructured":"Gr\u00fcn-wollny, I.; Paululat, T.; Hansske, F. G.; Sontag, B.Novel Drug: Oxachelin and its Derivatives. WO\/2005\/051411, 2005."},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/ja203577e"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.125"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2012.10"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00301846"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.55.593"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-142-8-2207"},{"key":"ref12\/cit12","first-page":"1","volume":"37","author":"Lane S. J.","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(95)00676-4"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.11.5189"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/np050091j"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2005.77"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.50.815"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/np400231r"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/np400308w"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/ol4033418"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2013.855932"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.37"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b01203"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2013.113"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.12.013"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1007\/s007260070029"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn079"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-011-9276-5"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2014.19"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa9134"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1021\/jo048076r"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2174\/1573406411208030481"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2015.04.006"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2004.06.010"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-007-9063-y"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/np980011u"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/np200597m"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.50.881"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.34.4554"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.34.1152"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.48.179"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.44.309"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.357"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.145"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ol062895b"},{"key":"ref46\/cit46","unstructured":"ACD\/NMR Predictor;Advanced Chemistry Development, Inc.:Toronto, Ontario (Canada), 2002."},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.47.782"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.47.774"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.21"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1517\/17460440802661443"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00426D"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1007\/BF01572599"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/BF01572600"},{"key":"ref54\/cit54","first-page":"4754","volume":"45","author":"Cavanaugh P. F.","year":"1985","journal-title":"Cancer Res."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"7936","DOI":"10.1016\/S0021-9258(17)39542-X","volume":"260","author":"Bergeron R. J.","year":"1985","journal-title":"J. Biol. Chem."},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1007\/BF00140480"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1996.tb01114.x"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.49.839"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1042\/bj1390407"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)00050-7"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(00)00591-3"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2000-9-1002"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2004.07.105"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)00934-6"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/np0496385"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.803"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.57.797"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2006.53"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1021\/np060612i"},{"key":"ref70\/cit70","unstructured":"Tsunakawa, M.; Chang, L.; Mamber, S. W.; Bursuker, I.; Hugill, R.Antitumor Antibiotic BMS-199687. US 5,811,440, 1998."},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2012.81"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1021\/np100588c"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1053869"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/nature17041"},{"key":"ref75\/cit75","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00429"}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.6b00948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T02:54:52Z","timestamp":1681700092000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.6b00948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,28]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1,27]]}},"alternative-id":["10.1021\/acs.jnatprod.6b00948"],"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.6b00948","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,28]]}}}