{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:19:45Z","timestamp":1788326385768,"version":"build-2803163510"},"reference-count":23,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/na","name":"Kaohsiung Medical University Research Foundation","doi-asserted-by":"publisher","award":["KMU-Q115006"],"award-info":[{"award-number":["KMU-Q115006"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Science and Technology Council, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112-2320-B-037-036-MY3"],"award-info":[{"award-number":["NSTC 112-2320-B-037-036-MY3"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Science and Technology Council, Taiwan","doi-asserted-by":"publisher","award":["NSTC 112-2320-B-038-015-MY3"],"award-info":[{"award-number":["NSTC 112-2320-B-038-015-MY3"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Science and Technology Council, Taiwan","doi-asserted-by":"publisher","award":["NSTC 113-2320-B-002-050-MY3"],"award-info":[{"award-number":["NSTC 113-2320-B-002-050-MY3"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Increasing exposure to blue light has raised concern about retinal injury, particularly in retinal pigment epithelial (RPE) cells. N-retinylidene-N-retinylethanolamine (A2E), a photosensitive fluorophore associated with age-related macular degeneration, is an important mediator of this process. In this study, feature-based molecular networking guided the identification of cordylutenes A\u2013J (1\u201310), a new molecular family of blue light\u2013protective fungal pigments from Cordyceps militaris. These metabolites possess a previously unreported symmetric all-E C20 polyene dicarbonyl skeleton with carotenoid-like UV absorption. They were characterized at the molecular-family level by shared UV features and diagnostic, internally consistent MS2 fragmentation patterns. Cordylutenes A (1) and B (2) were isolated as representative members for structural characterization. In an A2E-mediated blue-light injury model in ARPE-19 cells, the cordylutene complex (CCL, 1 \u03bcg\/mL) and cordylutene A (1, 0.1 \u03bcg\/mL) improved cell viability to 84.78 \u00b1 4.02% and 92.14 \u00b1 1.88%, respectively, and reduced intracellular oxidative stress to 63.67 \u00b1 3.33% and 43.89 \u00b1 9.59%, respectively. These findings identify cordylutenes as a new family of fungal pigments with protective effects in an A2E-mediated photo-oxidative retinal cell injury model.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00427","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:11:19Z","timestamp":1783624279000},"page":"2265-2274","source":"Crossref","is-referenced-by-count":0,"title":["Utilize Metabolomics\nMolecular Networking to Guide\nthe Discovery of Chemical Entities from\n                    <i>Cordyceps militaris<\/i>\n                    Against Blue Light Hazards"],"prefix":"10.1021","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6648-6010","authenticated-orcid":true,"given":"Ho-Cheng","family":"Wu","sequence":"first","affiliation":[{"name":"Kaohsiung Medical University , , ,","place":["Kaohsiung, Taiwan, 807378"]},{"name":"Kaohsiung Medical University Hospital , , ,","place":["Kaohsiung, Taiwan, 807378"]},{"name":"Kaohsiung Medical University , , ,","place":["Kaohsiung, Taiwan, 807378"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gu","sequence":"additional","affiliation":[{"name":"Kaohsiung Medical University , , ,","place":["Kaohsiung, Taiwan, 807378"]},{"name":"Institute of Fisheries Science, College of Life Science, National Taiwan University , ,","place":["Taipei, Taiwan, 106319"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"JoinCaring Co., Ltd. , ,","place":["Taipei, Taiwan, 100024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4243-4547","authenticated-orcid":true,"given":"Chung-Kuang","family":"Lu","sequence":"additional","affiliation":[{"name":"National Research Institute of Chinese Medicine , ,","place":["Taipei, Taiwan, 112026"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-3676","authenticated-orcid":true,"given":"Yi-Chieh","family":"Lee","sequence":"additional","affiliation":[{"name":"National Yang Ming Chiao Tung University , , ,","place":["Taipei, Taiwan, 112304"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Wei","family":"Yu","sequence":"additional","affiliation":[{"name":"JoinCaring Co., Ltd. , ,","place":["Taipei, Taiwan, 100024"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8036-7563","authenticated-orcid":true,"given":"Tzong-Huei","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Fisheries Science, College of Life Science, National Taiwan University , ,","place":["Taipei, Taiwan, 106319"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"issue":"12","key":"2026090200084956100_cit1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201900102","article-title":"The inner\nclock\u2500Blue light sets the human rhythm","volume":"12","author":"Wahl","year":"2019","journal-title":"J. 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Ophthalmol."},{"key":"2026090200084956100_cit5","doi-asserted-by":"publisher","first-page":"101779","DOI":"10.1016\/j.redox.2020.101779","article-title":"Oxidative\nstress in the light-exposed retina and its implication in age-related\nmacular degeneration","volume":"37","author":"Ozawa","year":"2020","journal-title":"Redox Biol."},{"key":"2026090200084956100_cit6","doi-asserted-by":"publisher","first-page":"112654","DOI":"10.1016\/j.jphotobiol.2023.112654","article-title":"Long-term blue light exposure impairs mitochondrial\ndynamics in the\nretina in light-induced retinal degeneration in vivo and in vitro","volume":"240","author":"Wang","year":"2023","journal-title":"J. Photochem. 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