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Clinical manifestations range from asymptomatic infection to chronic pulmonary disease. Despite the increasing endemic range and affected population, therapeutic strategies display moderate efficacy and adverse side effects. This study explores California\u2019s rich botanical diversity as a source for agents that inhibit the early stages of Coccidioides development. We established a screening protocol containing a colorimetric metabolism assay and microscopic imaging. We then applied this protocol to extracts derived from local plants in San Diego, California, and discovered a potent inhibitor, persenone A, from avocados.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00464","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:53:37Z","timestamp":1784166817000},"page":"2421-2428","source":"Crossref","is-referenced-by-count":0,"title":["Persenone A\nfrom Avocados Exhibits Potent Anti-Fungal\nActivity against\n                    <i>Coccidioides<\/i>"],"prefix":"10.1021","volume":"89","author":[{"given":"Vladimir","family":"Maslivetc","sequence":"first","affiliation":[{"name":"The Salk Institute for Biological Studies , , 10010 North Torrey Pines Rd. , , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Tejeda-Garibay","sequence":"additional","affiliation":[{"name":"University of California, Merced , , 5200 North Lake Road , , ,","place":["Merced, California, United States, 95343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeola","family":"Fagbayibo","sequence":"additional","affiliation":[{"name":"University of California, Merced , , 5200 North Lake Road , , ,","place":["Merced, California, United States, 95343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-4107","authenticated-orcid":true,"given":"James J.","family":"La Clair","sequence":"additional","affiliation":[{"name":"The Salk Institute for Biological Studies , , 10010 North Torrey Pines Rd. , , ,","place":["La Jolla, California, United States, 92037"]},{"name":"University of California, San Diego , , 9500 Gilman Drive , , ,","place":["La Jolla, California, United States, 92093-0358"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina K.","family":"Hoyer","sequence":"additional","affiliation":[{"name":"University of California, Merced , , 5200 North Lake Road , , ,","place":["Merced, California, United States, 95343"]},{"name":"University of California, Merced , , 5200 North Lake Road , , ,","place":["Merced, California, United States, 95343"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-0331","authenticated-orcid":true,"given":"Joseph P.","family":"Noel","sequence":"additional","affiliation":[{"name":"The Salk Institute for Biological Studies , , 10010 North Torrey Pines Rd. , , ,","place":["La Jolla, California, United States, 92037"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"Supplement_1","key":"2026090200084134800_cit1a","doi-asserted-by":"publisher","first-page":"S76","DOI":"10.1093\/mmy\/myy029","article-title":"Current Concepts and Future Directions\nin the Pharmacology and Treatment of Coccidioidomycosis","volume":"57","author":"Thompson","year":"2019","journal-title":"Med. 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Chem."},{"key":"2026090200084134800_cit20a","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.3390\/molecules24132354","article-title":"Chemical Profile and\nSafety Assessment of a Food-Grade Acetogenin-Enriched Antimicrobial\nExtract from Avocado Seed","volume":"24","author":"Rodri\u0301guez-Sa\u0301nchez","year":"2019","journal-title":"Molecules"},{"key":"2026090200084134800_cit20b","doi-asserted-by":"publisher","first-page":"7403","DOI":"10.1021\/jf401407s","article-title":"solation and Structure Elucidation\nof Avocado Seed (Persea americana) Lipid Derivatives\nThat Inhibit Clostridium sporogenes Endospore Germination","volume":"61","author":"Rodri\u0301guez-Sa\u0301nchez","year":"2013","journal-title":"J. Agric. Food. 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X."}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.6c00464","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jnprdf\/article-pdf\/89\/8\/2421\/65967898\/acs.jnatprod.6c00464.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jnprdf\/article-pdf\/89\/8\/2421\/65967898\/acs.jnatprod.6c00464.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:29:45Z","timestamp":1788323385000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jnprdf\/article\/89\/8\/2421\/5211379\/Persenone-A-from-Avocados-Exhibits-Potent-Anti"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,15]]},"published-print":{"date-parts":[[2026,8,28]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.6c00464","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]}}}