{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:51:37Z","timestamp":1791553897139,"version":"4.3.4"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2027,9,11]],"date-time":"2027-09-11T00:00:00Z","timestamp":1820620800000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Terpenoids are among the most chemically diverse natural product classes in the plant kingdom and are a source of numerous nature-inspired human medicines. One specific subclass, diterpenoids, defined by a C20 skeleton, includes attractive compounds such as the anticancer drug Taxol, the sweetener steviol, and the plant hormone gibberellin. One specialized group of ent-labdane (bicyclic) diterpenoids, primarily reported from the genus Andrographis (Acanthaceae), is the source of andrographolides, a diverse array of bioactive scaffolds with anti-inflammatory, antioxidant, anticancer, antimicrobial, and antihyperglycemic properties. Using high-throughput metabolomics, we set out to examine the molecular diversity within the Acanthaceae family, alongside other taxonomic lineages reported to accumulate diterpenoids. In a combined metabolomic investigation of 31 genera spanning Acanthaceae, Lamiaceae, and Poaceae, we annotated several reported andrographolide-type labdane diterpenoids and characteristic compounds unique to Acanthaceae. Integration of chemical, geographic, and taxonomic metadata with literature-driven assessments helped paint a chemotaxonomic and phylogeographic distribution map of andrographolide-type labdane diterpenoids across 163 countries. We found several species accumulate at least seven andrographolide-type compounds and another 17 labdane diterpenoids in our analysis. We conclude that labdane diterpenoid accumulation is more widespread, with multicontinental and shared evolutionary origins, than previously recognized.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00498","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:01:55Z","timestamp":1789149715000},"page":"2436-2451","source":"Crossref","is-referenced-by-count":0,"title":["Chemotaxonomic Map of Labdane Diterpenoids in Acanthaceae"],"prefix":"10.1021","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2046-6145","authenticated-orcid":true,"given":"Daniel","family":"Domingo-Ferna\u0301ndez","sequence":"first","affiliation":[{"name":"Enveda Therapeutics, Inc. , 5700 Flatiron Parkway , , ,","place":["Boulder, Colorado, United States, 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5700 Flatiron Parkway , , ,","place":["Boulder, Colorado, United States, 80301"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8468-5777","authenticated-orcid":true,"given":"Tendai","family":"Chisowa","sequence":"additional","affiliation":[{"name":"Enveda Therapeutics, Inc. , 5700 Flatiron Parkway , , ,","place":["Boulder, Colorado, United States, 80301"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"August","family":"Allen","sequence":"additional","affiliation":[{"name":"Enveda Therapeutics, Inc. , 5700 Flatiron Parkway , , ,","place":["Boulder, Colorado, United States, 80301"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Wee","sequence":"additional","affiliation":[{"name":"Enveda Therapeutics, Inc. , 5700 Flatiron Parkway , , ,","place":["Boulder, Colorado, United States, 80301"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswa","family":"Colluru","sequence":"additional","affiliation":[{"name":"Enveda Therapeutics, Inc. , 5700 Flatiron Parkway , , ,","place":["Boulder, Colorado, United States, 80301"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-6539","authenticated-orcid":true,"given":"Biswapriya B.","family":"Misra","sequence":"additional","affiliation":[{"name":"Enveda Therapeutics, Inc. , 5700 Flatiron Parkway , , ,","place":["Boulder, Colorado, United States, 80301"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2976-0671","authenticated-orcid":true,"given":"Andrew","family":"Katz","sequence":"additional","affiliation":[{"name":"Enveda Therapeutics, Inc. , 5700 Flatiron Parkway , , ,","place":["Boulder, Colorado, United States, 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