{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:19:21Z","timestamp":1788326361156,"version":"build-2803163510"},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/na","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2022YFC2804100"],"award-info":[{"award-number":["2022YFC2804100"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41376148"],"award-info":[{"award-number":["41376148"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/na","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473838"],"award-info":[{"award-number":["82473838"]}],"id":[{"id":"10.13039\/na","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thirteen new 4-acyl-5-amino-1H-imidazole alkaloids (1\u201313) were identified from cultures produced by the marine-derived Streptomyces sp. OUCMDZ-944 using feature-based molecular networking (FBMN)-guided isolation. Notably, compounds 1 and 2 were identified as phenyl-containing derivatives, specifically 5-amino-4-phenylpropionylimidazole (1) and 5-amino-4-phenylbutyrylimidazole (2). Ten isolates (4\u201313) are hydroxylated, with compound 13 being identified as a novel dimeric analogue. Furthermore, five methylated derivatives, 1a, 4a, 4b, 17a, and 17b, were synthesized. In an in vitro depression model, compounds 1, 4, 4a, 4b, 8, 16, and 17b were found to significantly reduce IL-1\u03b2 levels, while compounds 1, 1a, 4b, and 10 notably reversed the corticosterone-induced decrease in brain-derived neurotrophic factor (BDNF) expression, suggesting a potential antidepressant-like activity. In the zebrafish anxiety model, compounds 1, 1a, 4b, 16, and 17b significantly enhanced spontaneous locomotor activity, reduced thigmotaxis behavior, and increased time spent in the inner zone under various lighting conditions, demonstrating clear anxiolytic-like effects. These five compounds were identified as promising lead candidates with dual anxiolytic and antidepressant potential.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00591","type":"journal-article","created":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T13:48:19Z","timestamp":1783864099000},"page":"2359-2372","source":"Crossref","is-referenced-by-count":0,"title":["4-Acyl-5-aminoimidazole\nAlkaloids from a Marine-Derived\n                    <i>Streptomyces<\/i>\n                    sp.\nOUCMDZ-944"],"prefix":"10.1021","volume":"89","author":[{"given":"Yue","family":"Liu","sequence":"first","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]},{"name":"Qingdao Marine Science and Technology Center , , ,","place":["Qingdao, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowei","family":"Wen","sequence":"additional","affiliation":[{"name":"Biology Institute, Qilu University of Technology (Shandong Academy of Sciences) , ,","place":["Jinan, China, 250103"]},{"name":"Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province , ,","place":["Jinan, China, 250103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6628-8874","authenticated-orcid":true,"given":"Guoliang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]},{"name":"East China University of Science and Technology , , ,","place":["Shanghai, China, 200237"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikui","family":"Jian","sequence":"additional","affiliation":[{"name":"Biology Institute, Qilu University of Technology (Shandong Academy of Sciences) , ,","place":["Jinan, China, 250103"]},{"name":"Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province , ,","place":["Jinan, China, 250103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukang","family":"Gao","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linmeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Biology Institute, Qilu University of Technology (Shandong Academy of Sciences) , ,","place":["Jinan, China, 250103"]},{"name":"Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province , ,","place":["Jinan, China, 250103"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-3264","authenticated-orcid":true,"given":"Weiming","family":"Zhu","sequence":"additional","affiliation":[{"name":"Ocean University of China , , ,","place":["Qingdao, China, 266003"]},{"name":"Qingdao Marine Science and Technology Center , , ,","place":["Qingdao, China, 266237"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"2026090200085473200_cit1a","unstructured":"(a)\n          \n            Institute of Health Metrics and Evaluation.\n          \n          Global Health Data Exchange (GHDx). https:\/\/vizhub.healthdata.org\/gbd-results\/ (accessed March 2023)."},{"key":"2026090200085473200_cit1b","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1186\/s12888-025-06828-x","article-title":"Exploring\ndepression in adults over a decade: a review of longitudinal studies","volume":"25","author":"de Sousa","year":"2025","journal-title":"BMC Psychiatry"},{"key":"2026090200085473200_cit2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/d41586-022-02212-x","article-title":"Research round-up:\ndepression","volume":"608","author":"Svoboda","year":"2022","journal-title":"Nature"},{"key":"2026090200085473200_cit3","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0140-6736(22)02080-3","article-title":"Novel and emerging treatments for\nmajor depression","volume":"401","author":"Marwaha","year":"2023","journal-title":"Lancet"},{"key":"2026090200085473200_cit4","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1021\/acs.jnatprod.5b00746","article-title":"Nocarimidazoles A and\nB from a marine-derived actinomycete\nof the genus Nocardiopsis","volume":"78","author":"Leutou","year":"2015","journal-title":"J. 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Brain\nRes."}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.6c00591","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/jnprdf\/article-pdf\/89\/8\/2359\/65884610\/acs.jnatprod.6c00591.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/jnprdf\/article-pdf\/89\/8\/2359\/65884610\/acs.jnatprod.6c00591.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:27:23Z","timestamp":1788323243000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/jnprdf\/article\/89\/8\/2359\/5207023\/4-Acyl-5-aminoimidazole-Alkaloids-from-a-Marine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,7,12]]},"published-print":{"date-parts":[[2026,8,28]]}},"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.6c00591","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,12]]}}}