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Over the past decade, renewed interest in this class has led to the discovery of diverse nucleoside analog natural products from microbial, marine, and fungal sources, often featuring unprecedented modifications to the nucleobase, and\/or the ribose sugar 2\u2032, 3\u2032, 4\u2032, and 5\u2032 positions. This review provides a comprehensive update of novel nucleoside natural products reported between January 2015 and January 2026, encompassing their isolation, structural elucidation, biological activities, and synthetic and biosynthetic studies. Expansions to key families such as muraymycins, pseudouridimycin, tunicamycins, and puromycin analogs are discussed alongside structural revisions and unique metabolites that expand the chemical space of nucleosides. By consolidating recent advances and highlighting emerging structural and biological trends, this review aims to provide a resource for researchers in natural product chemistry, chemical biology, and medicinal chemistry, and to inspire new nucleoside drug discovery programs.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00624","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:44:24Z","timestamp":1783691064000},"page":"2031-2061","source":"Crossref","is-referenced-by-count":0,"title":["Nucleoside\nAnalog Natural Products: Over a Decade\nof Advances in Isolation, Biological Activity, and Synthesis"],"prefix":"10.1021","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1298-3157","authenticated-orcid":true,"given":"Malvika","family":"Raj","sequence":"first","affiliation":[{"name":"Auckland University of Technology , , ,","place":["Auckland, New Zealand, 1010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8578-622X","authenticated-orcid":true,"given":"Sabrina Y.","family":"Harada","sequence":"additional","affiliation":[{"name":"Auckland University of Technology , , ,","place":["Auckland, New Zealand, 1010"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9280-2742","authenticated-orcid":true,"given":"Emma K.","family":"Davison","sequence":"additional","affiliation":[{"name":"Auckland University of Technology , , ,","place":["Auckland, New Zealand, 1010"]},{"name":"University of Auckland , , ,","place":["Auckland, New Zealand, 1010"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"2026090715160040400_cit1","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly\nFour Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. 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