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The structures and configurations of compounds 1\u22126 were elucidated via comprehensive spectroscopic analysis, nuclear magnetic resonance (NMR) calculations, DP4+ analysis, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction. All compounds were evaluated for their neuroprotective activity against H2O2-induced injury in PC12 cells, and compound 1 exhibited potent neuroprotective activity, with an EC50 value of 1.02 \u00b1 0.18 \u03bcM. Nuclear receptor subfamily 3 group C member 2 (NR3C2) was identified as a potential target through which compound 1 exerts its neuroprotective effect through virtual screening, molecular dynamics (MD) simulation, and experimental validation. The discovery of compound 1 broadens the chemical diversity of known SNTs and provides a novel bioactive scaffold for natural product development.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00640","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:24:01Z","timestamp":1788452641000},"page":"2513-2526","source":"Crossref","is-referenced-by-count":0,"title":["Schinortriterpenoids with an Unprecedented Oxatricyclo[4.2.1.04,8]nonane Bridged System from\n                    <i>Schisandra chinensis<\/i>"],"prefix":"10.1021","volume":"89","author":[{"given":"Peng","family":"Jiang","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine , , ,","place":["Harbin, China, 150040"]},{"name":"Traditional Chinese Medicine Biological Genetics , , ,","place":["Harbin, China, 150040"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Meng","family":"Luo","sequence":"additional","affiliation":[{"name":"Heilongjiang 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