{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:22:52Z","timestamp":1792790572113,"version":"4.5.0"},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"name":"Shuang Cheng cooperative agreement research grant of Yibin, China","award":["YBSCXY2025010018"],"award-info":[{"award-number":["YBSCXY2025010018"]}]},{"name":"Chongqing Key Project of Technological Innovation and Application Development","award":["CSTB2025TIAD-KPX0093"],"award-info":[{"award-number":["CSTB2025TIAD-KPX0093"]}]},{"name":"Key Joint project of Innovation and Application development of Traditional Chinese Medicine of Chongqing Science and Technology Commission and Chongqing Health Commission","award":["2026ZYZD005"],"award-info":[{"award-number":["2026ZYZD005"]}],"id":[{"id":"https:\/\/ror.org\/05w9erc61","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Guided by the feature-based molecular networking approach, twenty-five previously undescribed sesquiterpenoid dimers (SDs) designated Inulaenoids A\u2212Y (1\u22124, 8\u221225, and 27\u221229) along with four known analogues were isolated from the roots of Inula helenium L. and Inula racemosa Hook. f. Their structures and absolute configuration were unambiguously elucidated by spectroscopic data, X-ray diffraction, and theoretical calculations. Structurally, compounds 1\u221219 are rare SDs featuring two eudesmane units directly constructed through C\u2212C bonds, including C-13\u2212C-13\u2032, C-13\u2212C-11\u2032, C-11\u2212C-13\u2032, and through a previously undescribed C-13\u2212C-8\u2032 connection. Fifteen compounds (3, 4, 10, 15\u221218, 20\u221223 and 25\u221228) showed potent cytotoxic activity to Huh-7 and HepG2 cells with the IC50 values ranging from 1.9 \u00b1 0.1 to 20.2 \u00b1 0.3 \u03bcM. Among them, four compounds (3, 4, 10 and 17) displayed binding to proto-oncogenic c-Fos. Notably, compound 17 exhibited the highest binding affinity to recombinant human c-Fos, thereby activating TP53 transcription and subsequently driving BAX\/Bcl2-mediated apoptosis in liver cancer cells. Taken together, this study expands the structural diversity of sesquiterpenoid dimers from genus Inula as novel c-Fos-targeting lead compounds, providing new insights for the development of natural product-based anti-hepatocellular carcinoma agents.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00758","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T17:07:02Z","timestamp":1792775222000},"page":"2656-2681","source":"Crossref","is-referenced-by-count":0,"title":["Sesquiterpenoid Dimers from the Roots of Two Species of the Genus\n                    <i>Inula<\/i>\n                    with Cytotoxic Activity on Hepatocellular Carcinoma Cells"],"prefix":"10.1021","volume":"89","author":[{"given":"Feng","family":"Ju","sequence":"first","affiliation":[{"name":"Southwest University , , ,","place":["Chongqing, P. R. 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