{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:52:56Z","timestamp":1791553976582,"version":"4.3.4"},"reference-count":63,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100023581","name":"National Science Foundation Graduate Research Fellowship Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000153","name":"Division of Biological Infrastructure","doi-asserted-by":"publisher","award":["DBI-2400327"],"award-info":[{"award-number":["DBI-2400327"]}],"id":[{"id":"10.13039\/100000153","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health (NIH)","award":["5U24DK133658-02"],"award-info":[{"award-number":["5U24DK133658-02"]}]},{"name":"National Institutes of Health (NIH)","award":["F31AI200270"],"award-info":[{"award-number":["F31AI200270"]}]},{"name":"National Institutes of Health (NIH)","award":["R21GM148870"],"award-info":[{"award-number":["R21GM148870"]}]},{"name":"National Institutes of Health (NIH)","award":["R25GM051765"],"award-info":[{"award-number":["R25GM051765"]}]},{"name":"National Institutes of Health (NIH)","award":["R35GM147235"],"award-info":[{"award-number":["R35GM147235"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Microbial libraries remain an important resource for natural product discovery; however, constructing taxonomically and chemically diverse collections remains a challenge. Advances in dereplication strategies, including molecular networking, have reduced the rediscovery of known bioactive molecules and facilitated the identification of novel chemical scaffolds, but these approaches are typically applied after library construction. Furthermore, many dereplication workflows require fermentation and extraction, increasing the time needed to assess a microbe\u2019s metabolite profile. Here, we integrate matrix-assisted laser desorption\/ionization tandem mass spectrometry (MALDI-MS\/MS) into the bioinformatics platform IDBac, enabling characterization of microbial taxonomic identity, metabolite production potential, and preliminary metabolite annotation through GNPS2 molecular networking. This workflow facilitates strain prioritization by providing metabolite annotations directly from single microbial colonies prior to scale-up and extraction. Application of this approach to marine actinomycetes enabled the annotation of lavanducyanin and multiple napyradiomycin analogs. Subsequent investigation led to the discovery of napyradiomycin B8 from marine Streptomyces sp. CNZ-289, which was confirmed by 1D and 2D NMR spectroscopy and MALDI-MS\/MS. Expanding this workflow to 25 commensal marine vertebrate-derived bacterial isolates resulted in the annotation of known bioactive natural products, including surugamides, antimycins, desferrioxamine siderophores, and the isolation and elucidation of harmane derivatives using NMR.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00765","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:24:02Z","timestamp":1788150242000},"page":"2643-2655","source":"Crossref","is-referenced-by-count":0,"title":["MALDI Tandem Mass Spectrometry for Colony-Based Dereplication of Natural Products"],"prefix":"10.1021","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0601-5460","authenticated-orcid":true,"given":"Robert A.","family":"Shepherd","sequence":"first","affiliation":[{"name":"University of California Santa Cruz , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6717-5526","authenticated-orcid":true,"given":"Limar Y.","family":"Gad","sequence":"additional","affiliation":[{"name":"University of California Santa Cruz , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Strobel","sequence":"additional","affiliation":[{"name":"University of California Riverside , , , ,","place":["Riverside, California, United States, 92521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-7855","authenticated-orcid":true,"given":"Gordon T.","family":"Luu","sequence":"additional","affiliation":[{"name":"University of California Santa Cruz , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Feng","sequence":"additional","affiliation":[{"name":"University of California Santa Cruz , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"De Silva","sequence":"additional","affiliation":[{"name":"University of California Santa Cruz , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-6455","authenticated-orcid":true,"given":"Shaun M. K.","family":"McKinnie","sequence":"additional","affiliation":[{"name":"University of California Santa Cruz , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7647-6097","authenticated-orcid":true,"given":"Mingxun","family":"Wang","sequence":"additional","affiliation":[{"name":"University of California Riverside , , , ,","place":["Riverside, California, United States, 92521"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9223-7977","authenticated-orcid":true,"given":"Laura M.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"University of California Santa Cruz , , , ,","place":["Santa Cruz, California, United States, 95064"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"issue":"9","key":"2026100909082988900_cit1","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1021\/acscentsci.5c00804","article-title":"An Assessment of Chemical Diversity in Microbial Natural Products","volume":"11","author":"Linington","year":"2025","journal-title":"ACS Cent. Sci."},{"key":"2026100909082988900_cit2","first-page":"226","article-title":"On the Antibacterial Action of Cultures of a Penicillium, with Special Reference to Their Use in the Isolation of B. Influenzae","volume":"10","author":"Fleming","year":"1929","journal-title":"Br. J. Exp. Pathol."},{"key":"2026100909082988900_cit3","unstructured":"Discovery and Development of Penicillin; American Chemical Society. https:\/\/www.acs.org\/education\/whatischemistry\/landmarks\/flemingpenicillin.html (accessed 22 04 2026)."},{"issue":"19","key":"2026100909082988900_cit4","doi-asserted-by":"publisher","first-page":"4981","DOI":"10.1073\/pnas.1801247115","article-title":"Coupling MALDI-TOF Mass Spectrometry Protein and Specialized Metabolite Analyses to Rapidly Discriminate Bacterial Function","volume":"115","author":"Clark","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"2026100909082988900_cit5","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1021\/acs.jnatprod.9b00168","article-title":"Minimizing Taxonomic and Natural Product Redundancy in Microbial Libraries Using MALDI-TOF MS and the Bioinformatics Pipeline IDBac","volume":"82","author":"Costa","year":"2019","journal-title":"J. Nat. Prod."},{"issue":"3","key":"2026100909082988900_cit6","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.mimet.2013.07.021","article-title":"Ribosomal Proteins as Biomarkers for Bacterial Identification by Mass Spectrometry in the Clinical Microbiology Laboratory","volume":"94","author":"Suarez","year":"2013","journal-title":"J. Microbiol. 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Chem."},{"issue":"12","key":"2026100909082988900_cit34","doi-asserted-by":"publisher","first-page":"4268","DOI":"10.1021\/ja201088k","article-title":"A Stereoselective Vanadium-Dependent Chloroperoxidase in Bacterial Antibiotic Biosynthesis","volume":"133","author":"Bernhardt","year":"2011","journal-title":"J. Am. Chem. Soc."},{"issue":"12","key":"2026100909082988900_cit35","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/nchem.2829","article-title":"A Unifying Paradigm for Naphthoquinone-Based Meroterpenoid (Bio)Synthesis","volume":"9","author":"Miles","year":"2017","journal-title":"Nat. Chem."},{"issue":"51","key":"2026100909082988900_cit36","doi-asserted-by":"publisher","first-page":"17840","DOI":"10.1021\/jacs.8b10134","article-title":"Total Enzyme Syntheses of Napyradiomycins A1 and B1","volume":"140","author":"McKinnie","year":"2018","journal-title":"J. Am. Chem. 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Prod."},{"issue":"1","key":"2026100909082988900_cit45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1021\/np400466j","article-title":"Napyradiomycin Derivatives, Produced by a Marine-Derived Actinomycete, Illustrate Cytotoxicity by Induction of Apoptosis","volume":"77","author":"Farnaes","year":"2014","journal-title":"J. Nat. Prod."},{"issue":"10","key":"2026100909082988900_cit46","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1039\/d0np00018c","article-title":"Meroterpenoid Natural Products from Streptomyces Bacteria - the Evolution of Chemoenzymatic Syntheses","volume":"37","author":"Murray","year":"2020","journal-title":"Nat. Prod. Rep."},{"issue":"1","key":"2026100909082988900_cit47","doi-asserted-by":"publisher","DOI":"10.3390\/md18010022","article-title":"New Napyradiomycin Analogues from Streptomyces Sp. Strain CA-271078","volume":"18","author":"Carretero-Molina","year":"2019","journal-title":"Mar. 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