{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:52:24Z","timestamp":1791553944456,"version":"4.3.4"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT204058"],"award-info":[{"award-number":["PJT204058"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>As part of our continuing search for antifungal natural products, we investigated the secondary metabolites of Streptomyces sp. SID10815, an actinomycete isolated from a ground-nesting bee-associated environment that exhibited notable antifungal activity in preliminary screenings. Herein, we report the discovery of four new N-acetylcysteine-modified ansamycins (1\u22124) and three new hydroxymycotrienin analogues (5\u22127), together with six known ansamycins (8\u221213), produced by this strain. These metabolites were detected and prioritized through a metabolomics-guided dereplication strategy integrating LC\u2212MS profiling and bioactivity correlation. Their structures were elucidated by comprehensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (1H, 13C, COSY, HSQC, HMBC, and NOESY) in combination with high-resolution mass spectrometry. The newly identified metabolites expand the structural diversity of the ansamycin family and provide a basis for future structure\u2212activity relationship studies of N-acetylcysteine-conjugated ansamycins. These findings define a distinctive ansamycin profile of Streptomyces sp. SID10815 that may serve as a useful chemical signature for future comparative studies of insect-associated actinomycetes.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.6c00814","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:35:17Z","timestamp":1788327317000},"page":"2694-2705","source":"Crossref","is-referenced-by-count":0,"title":["<i>N<\/i>\n                    -Acetylcysteine-Conjugated Benzoxazomycins and Hydroxymycotrienin Derivatives from a Hymenoptera-Associated\n                    <i>Streptomyces<\/i>\n                    sp. SID10815"],"prefix":"10.1021","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6948-3396","authenticated-orcid":true,"given":"Won Se","family":"Suh","sequence":"first","affiliation":[{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]},{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Smith","sequence":"additional","affiliation":[{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]},{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Artavia-Leo\u0301n","sequence":"additional","affiliation":[{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]},{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian I.","family":"Rosati","sequence":"additional","affiliation":[{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]},{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Matthews","sequence":"additional","affiliation":[{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]},{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-3997","authenticated-orcid":false,"given":"Cameron R.","family":"Currie","sequence":"additional","affiliation":[{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]},{"name":"McMaster University , , , ,","place":["Hamilton, Ontario, Canada, L8S 4L8"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026100909075842600_cit1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mmbr.00019-15","article-title":"Taxonomy, Physiology, and Natural Products of Actinobacteria","volume":"80","author":"Barka","year":"2016","journal-title":"Microbiol. 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