{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T22:41:37Z","timestamp":1781304097601,"version":"3.54.1"},"reference-count":73,"publisher":"American Chemical Society (ACS)","issue":"10","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 630"],"award-info":[{"award-number":["SFB 630"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K08319"],"award-info":[{"award-number":["16K08319"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2017,10,27]]},"DOI":"10.1021\/acs.jnatprod.7b00650","type":"journal-article","created":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T14:32:48Z","timestamp":1508337168000},"page":"2807-2817","source":"Crossref","is-referenced-by-count":42,"title":["Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana <i>Ancistrocladus ileboensis,<\/i> with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line"],"prefix":"10.1021","volume":"80","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[{"name":"Institute\rof Organic Chemistry, University of W\u00fcrzburg, Am Hubland, D-97074 W\u00fcrzburg, Germany"},{"name":"State\rKey Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource\rUtilization, and Key Laboratory of Plant Resources and Chemistry of\rArid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raina","family":"Seupel","sequence":"additional","affiliation":[{"name":"Institute\rof Organic Chemistry, University of W\u00fcrzburg, Am Hubland, D-97074 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-1004","authenticated-orcid":true,"given":"Torsten","family":"Bruhn","sequence":"additional","affiliation":[{"name":"Institute\rof Organic Chemistry, University of W\u00fcrzburg, Am Hubland, D-97074 W\u00fcrzburg, Germany"},{"name":"Federal Institute for Risk Assessment, Max-Dohrn-Stra\u00dfe 8-10, D-10589 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Feineis","sequence":"additional","affiliation":[{"name":"Institute\rof Organic Chemistry, University of W\u00fcrzburg, Am Hubland, D-97074 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland"},{"name":"University of Basel, Petersplatz\r1, CH-4003 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland"},{"name":"University of Basel, Petersplatz\r1, CH-4003 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virima","family":"Mudogo","sequence":"additional","affiliation":[{"name":"Facult\u00e9\rdes Sciences, Universit\u00e9 de Kinshasa, B.P. 202, Kinshasa XI, Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-193X","authenticated-orcid":true,"given":"Suresh","family":"Awale","sequence":"additional","affiliation":[{"name":"Division\rof Natural Drug Discovery, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3583-5935","authenticated-orcid":true,"given":"Gerhard","family":"Bringmann","sequence":"additional","affiliation":[{"name":"Institute\rof Organic Chemistry, University of W\u00fcrzburg, Am Hubland, D-97074 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2017,10,18]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","unstructured":"aBringmann, G.; Pokorny, F.InThe Alkaloids;Cordell, G. A., Ed.Academic Press:New York, 1995; Vol.46, Chapter 4, pp127\u2013271.","DOI":"10.1016\/S0099-9598(08)60288-6"},{"key":"ref1\/cit1b","unstructured":"bBringmann, G.; G\u00fcnther, C.; Ochse, M.; Schupp, O.; Tasler, S.InProgress in the Chemistry of Organic Natural Products;Herz, W.; Falk, H.; Kirby, G. W.; Moore, R. E., Eds.Springer:Wien, 2001; Vol.82, pp111\u2013123."},{"key":"ref1\/cit1c","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2533\/chimia.1998.18","volume":"52","author":"Bringmann G.","year":"1998","journal-title":"Chimia"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2015.09.014"},{"key":"ref3\/cit3a","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1128\/AAC.41.11.2533","volume":"41","author":"Fran\u00e7ois G.","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref3\/cit3b","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.10.072"},{"key":"ref3\/cit3c","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.02.050"},{"key":"ref3\/cit3d","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA03038A"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202755"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/c3np70030e"},{"key":"ref6\/cit6a","doi-asserted-by":"publisher","DOI":"10.2174\/092986706778201611"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.048"},{"key":"ref7\/cit7a","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00936-06"},{"key":"ref7\/cit7b","doi-asserted-by":"publisher","DOI":"10.1021\/jo061626w"},{"key":"ref7\/cit7c","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2010.10.006"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00967"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.09.010"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2016.09.009"},{"key":"ref10\/cit10a","doi-asserted-by":"publisher","DOI":"10.1021\/jm00038a003"},{"key":"ref10\/cit10b","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.2.484"},{"key":"ref11\/cit11a","doi-asserted-by":"publisher","DOI":"10.1021\/np9700679"},{"key":"ref11\/cit11b","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2016.04.005"},{"key":"ref12\/cit12a","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00304-7"},{"key":"ref12\/cit12b","doi-asserted-by":"publisher","DOI":"10.1021\/ac001503q"},{"key":"ref13\/cit13a","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200903247"},{"key":"ref13\/cit13b","doi-asserted-by":"publisher","DOI":"10.1021\/ol4005883"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b00209"},{"key":"ref15\/cit15a","doi-asserted-by":"publisher","DOI":"10.2307\/4113632"},{"key":"ref15\/cit15b","first-page":"360","volume":"92","author":"Taylor C. M.","year":"2005","journal-title":"Ann. Missouri Bot. Gard."},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2307\/4118000"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.5091\/plecevo.2010.365"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(96)00357-3"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(98)00231-3"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000440"},{"key":"ref21\/cit21a","doi-asserted-by":"publisher","DOI":"10.1021\/np030077b"},{"key":"ref21\/cit21b","doi-asserted-by":"publisher","DOI":"10.1021\/np000247+"},{"key":"ref21\/cit21c","doi-asserted-by":"publisher","DOI":"10.1039\/c0np00069h"},{"key":"ref21\/cit21d","doi-asserted-by":"publisher","DOI":"10.2174\/092986706778201611"},{"key":"ref22\/cit22a","first-page":"601","volume":"105","author":"Bringmann G.","year":"1996","journal-title":"Bull. Soc. Chim. Belg."},{"key":"ref22\/cit22b","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(00)00940-6"},{"key":"ref22\/cit22c","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201501657"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3143"},{"key":"ref24\/cit24","first-page":"6201","volume":"60","author":"Izuishi K.","year":"2000","journal-title":"Cancer Res."},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.3390\/cancers6031769"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3114"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"ref28\/cit28a","doi-asserted-by":"publisher","DOI":"10.1021\/np300295h"},{"key":"ref28\/cit28b","doi-asserted-by":"publisher","DOI":"10.1021\/np300596c"},{"key":"ref28\/cit28c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00381"},{"key":"ref28\/cit28d","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00784"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22600"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200801121"},{"key":"ref31\/cit31a","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"ref31\/cit31b","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21759"},{"key":"ref32\/cit32a","doi-asserted-by":"publisher","DOI":"10.1039\/b508541a"},{"key":"ref32\/cit32b","doi-asserted-by":"publisher","DOI":"10.1039\/b515623h"},{"key":"ref33\/cit33a","doi-asserted-by":"publisher","DOI":"10.1063\/1.3646921"},{"key":"ref33\/cit33b","doi-asserted-by":"publisher","DOI":"10.1063\/1.3533441"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ct100117s"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/ct300715s"},{"key":"ref36\/cit36a","doi-asserted-by":"publisher","DOI":"10.1063\/1.4811331"},{"key":"ref36\/cit36b","doi-asserted-by":"publisher","DOI":"10.1016\/j.comptc.2014.02.023"},{"key":"ref36\/cit36c","doi-asserted-by":"publisher","DOI":"10.1039\/C3CP54517B"},{"key":"ref36\/cit36d","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpca.5b01680"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22138"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2004.06.011"},{"key":"ref39\/cit39a","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.81"},{"key":"ref39\/cit39b","unstructured":"bNeese, F.; Aravena, D.; Atanasov, M.; Becker, U.; Brehm, M.; Bykov, D.; Chilkuri, V. G.; Datta, D.; Dutta, A. K.; Ganyushin, D.; Guo, Y.; Hansen, A.; Huntington, L.; Izs\u00e1k, R.; Kollmar, C.; Kossmann, S.; Krupicka, M.; Lenk, D.; Liakos, D.; Manganas, D.; Pantazis, D.; Petrenko, T.; Pinski, P.; Reimann, C.; Retegan, M.; Riplinger, C.; Risthaus, T.; Roemelt, M.; Saitow, M.; Sandh\u00f6fer, B.; Schapiro, I.; Sivalingam, K.; Stoychev, G.; Wezisla, B.; Wennmohs, F.ORCA, version 4.0.0.2;MPI CEC:M\u00fchlheim a.d.R., Germany, 2017."},{"key":"ref40\/cit40","unstructured":"Bruhn, T.; Schauml\u00f6ffel, A.; Hemberger, Y.; Pescitelli, G.SpecDis, Version 1.70.1;www.specdis-software.jimdo.com:Berlin, Germany, 2017."},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.3390\/md8010047"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2016.17.4.1655"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2004.tb03247.x"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092444"}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.7b00650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:54:48Z","timestamp":1682297688000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.7b00650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,18]]},"references-count":73,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10,27]]}},"alternative-id":["10.1021\/acs.jnatprod.7b00650"],"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.7b00650","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,18]]}}}