{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:50:30Z","timestamp":1793832630241,"version":"4.6.1"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"3","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK058404"],"award-info":[{"award-number":["P30DK058404"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16POST27250138"],"award-info":[{"award-number":["16POST27250138"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["F31AT009938"],"award-info":[{"award-number":["F31AT009938"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R01AT006896"],"award-info":[{"award-number":["R01AT006896"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008460","name":"National Center for Complementary and Integrative Health","doi-asserted-by":"publisher","award":["R34AT007837"],"award-info":[{"award-number":["R34AT007837"]}],"id":[{"id":"10.13039\/100008460","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA174926"],"award-info":[{"award-number":["R01CA174926"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"US Department of Agriculture","doi-asserted-by":"crossref","award":["2014-38420-21799"],"award-info":[{"award-number":["2014-38420-21799"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2019,3,22]]},"DOI":"10.1021\/acs.jnatprod.8b00873","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T20:20:00Z","timestamp":1550866800000},"page":"500-509","source":"Crossref","is-referenced-by-count":47,"title":["Beta-Glucuronidase Catalyzes Deconjugation and Activation of Curcumin-Glucuronide in Bone"],"prefix":"10.1021","volume":"82","author":[{"given":"Andrew G.","family":"Kunihiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula B.","family":"Luis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Brickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen B.","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-H. Sherry","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4215-967X","authenticated-orcid":true,"given":"Claus","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9826-5407","authenticated-orcid":true,"given":"Janet L.","family":"Funk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"issue":"4","key":"ref1\/cit1","first-page":"607","volume":"11","author":"Velayudhan K. C.","year":"2012","journal-title":"Indian J. Tradit. Knowl."},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2016.08.002"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.03.081"},{"issue":"4","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"438","DOI":"10.20945\/2359-3997000000060","volume":"62","author":"Khanizadeh F.","year":"2018","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1021\/jf101873f"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/art.22180"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1021\/np300663v"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.06.007"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.08.025"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23242"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/np050327j"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5674"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1159\/000494537"},{"issue":"1","key":"ref14\/cit14","first-page":"486","volume":"27","author":"Pan M.","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957450"},{"key":"ref16\/cit16","first-page":"1058","volume":"61","author":"Ireson C.","year":"2001","journal-title":"Cancer Res."},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601623"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1749-y"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00868-7"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2018.09.021"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.11.021"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.3390\/antiox4040750"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/srep22146"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080843"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO01178C"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.08.049"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700999"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1177\/15.11.680"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.07.007"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199733010-00003"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.104166"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.30.18770"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M312392200"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-006-0355-x"},{"key":"ref35\/cit35","first-page":"1894","volume":"7","author":"Sharma R. A.","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-2693"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.178806"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2523082055"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(85)90203-1"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1007\/BF00554527"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2012.03.022"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-472704-5.50044-6"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.9.9.4074"},{"issue":"1","key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/genetics\/121.1.119","volume":"121","author":"Wawrzyniak C. J.","year":"1989","journal-title":"Genetics"},{"issue":"5","key":"ref45\/cit45","first-page":"1199","volume":"10","author":"Morrow A. G.","year":"1950","journal-title":"J. Natl. Cancer Inst."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/genetics\/59.3.335","volume":"59","author":"Ganschow R.","year":"1968","journal-title":"Genetics"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1210\/endo-52-5-536"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1007\/BF00484702"},{"issue":"3","key":"ref49\/cit49","first-page":"657","volume":"10","author":"Morrow A. G.","year":"1949","journal-title":"J. Natl. Cancer Inst."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.11.6474"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114010"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/360749a0"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg119"},{"issue":"1","key":"ref54\/cit54","first-page":"207","volume":"136","author":"Vogler C.","year":"1990","journal-title":"Am. J. Pathol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/9781118453926.ch3","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Ross F. P.","year":"2013"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/9781118453926.ch37","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Griffith J. F.","year":"2013"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.618785"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319340013"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72339"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.03.002"},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-61779-415-5_13","volume-title":"Bone Research Protocols","volume":"816","author":"Collin-Osdoby P.","year":"2012"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-014-1469-1"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.3791\/53936"},{"issue":"6","key":"ref65\/cit65","first-page":"969","volume":"82","author":"Glaser J.","year":"1973","journal-title":"J. Lab. Clin. Med."},{"issue":"2","key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0021-9258(17)35214-6","volume":"166","author":"Talalay P.","year":"1946","journal-title":"J. Biol. Chem."},{"key":"ref67\/cit67","unstructured":"McDonald, K. Overcoming the coomassie blues. http:\/\/www.bio-rad.com\/webroot\/web\/pdf\/lsr\/literature\/Bulletin_5939.pdf (accessed Jul 10, 2018)."},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.05.003"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.01.007"}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.8b00873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T13:37:36Z","timestamp":1681652256000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.8b00873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,22]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3,22]]}},"alternative-id":["10.1021\/acs.jnatprod.8b00873"],"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.8b00873","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,22]]}}}