{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:35:08Z","timestamp":1784003708675,"version":"3.55.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Nauki i Szkolnictwa Wyzszego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003413","name":"Bundesministerium f?r Wissenschaft, Forschung und Wirtschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003413","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2019,2,22]]},"DOI":"10.1021\/acs.jnatprod.8b00939","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T21:24:43Z","timestamp":1547760283000},"page":"375-385","source":"Crossref","is-referenced-by-count":13,"title":["Eupatoriopicrin Inhibits Pro-inflammatory Functions of Neutrophils via Suppression of IL-8 and TNF-alpha Production and p38 and ERK 1\/2 MAP Kinases"],"prefix":"10.1021","volume":"82","author":[{"given":"Barbara","family":"Michalak","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Warsaw 02-097, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub P.","family":"Piwowarski","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Warsaw 02-097, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1876-1321","authenticated-orcid":true,"given":"Sebastian","family":"Granica","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Warsaw 02-097, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Waltenberger","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy\/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-0967","authenticated-orcid":true,"given":"Atanas G.","family":"Atanasov","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Animal Breeding of the Polish Academy of Science, Jastrz\u0119biec 05-552, Poland"},{"name":"Department of Pharmacognosy, University of Vienna, Vienna 1010, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafaat Y.","family":"Khan","sequence":"additional","affiliation":[{"name":"Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria"},{"name":"Department of Zoology, University of Sargodha, Sargodha 40010, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M.","family":"Breuss","sequence":"additional","affiliation":[{"name":"Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Uhrin","sequence":"additional","affiliation":[{"name":"Institute of Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna 1090, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"\u017by\u017cy\u0144ska-Granica","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, Warsaw 02-097, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stojakowska","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Department of Phytochemistry, Polish Academy of Sciences, Krak\u00f3w 30-024, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Stuppner","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy\/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck 6020, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-2849","authenticated-orcid":true,"given":"Anna K.","family":"Kiss","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Warsaw 02-097, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-020711-074942"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","DOI":"10.1142\/p823","volume-title":"The Neutrophils. New Outlook for Old Cells","author":"Gabrilovich D.","year":"2013"},{"key":"ref3\/cit3","first-page":"313","volume":"34","author":"Casc\u00e3o R.","year":"2009","journal-title":"Acta Reumatol. Port."},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5257"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309901200"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2MA1214-599R"},{"key":"ref7\/cit7","volume-title":"The Neutrophil. Chem Immunol Allergy","author":"Cloutier A.","year":"2003"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.1.563"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0366-8"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00600.x"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02224.x"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.14a23.x"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.5.1132"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20906"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.109269"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70462-8"},{"key":"ref17\/cit17","first-page":"185","volume":"23","author":"Repka-Ramirez S.","year":"2002","journal-title":"Allergy Asthma Proc."},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.07.001"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02646.x"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1159\/000091969"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006323.pub2"},{"key":"ref22\/cit22","unstructured":"Kiss, A. K.; Granica, S.; Piwowarski, P. J.; Stojakowska, A.; Michalak, B.; Stuppner, H. Oral presentation on 10th International Symposium on Chromatography of Natural Products; Lublin, Poland, 2016."},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.05.010"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)80481-1"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)89341-3"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.27.2539"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1978.1345"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.49.3.236"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.3109\/08923979909007117"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1021\/np1003017"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2016.08.011"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200707-1134OC"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2008.00848.x"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.4049\/jimmunol.135.3.2057","volume":"135","author":"Wolfson M.","year":"1985","journal-title":"J. Immunol."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201202382"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.4049\/jimmunol.160.4.1982","volume":"160","author":"Zu Y. L.","year":"1998","journal-title":"J. Immunol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1182\/blood.V89.9.3421","volume":"89","author":"McDonald P. P.","year":"1997","journal-title":"Blood"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0806536"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4510"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/np100550t"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b01055"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.13"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1996.46752.x"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.1.44-47.2001"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1211\/0022357021778637"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00060"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00149-9"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01309.x"},{"key":"ref50\/cit50","volume-title":"Flora Europeae","author":"Tutin T. G.","year":"1972"}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.jnatprod.8b00939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T04:24:38Z","timestamp":1681705478000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jnatprod.8b00939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,22]]}},"alternative-id":["10.1021\/acs.jnatprod.8b00939"],"URL":"https:\/\/doi.org\/10.1021\/acs.jnatprod.8b00939","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"value":"0163-3864","type":"print"},{"value":"1520-6025","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,17]]}}}