{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:54:37Z","timestamp":1792580077941,"version":"4.5.0"},"reference-count":28,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["Please change NRF-2015-0001276 to NRF-2019R1A2C1006214"],"award-info":[{"award-number":["Please change NRF-2015-0001276 to NRF-2019R1A2C1006214"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cimicifuga dahurica has traditionally been used as an antipyretic, analgesic, and anti-inflammatory agent and as a treatment for uterine and anal prolapse. This study has investigated the potential beneficial effects of this medicinal plant and its components on Alzheimer\u2019s disease (AD) with a focus on amyloid beta (A\u03b2) production and scopolamine-induced memory impairment in mice. An ethanol extract from C. dahurica roots decreased A\u03b2 production in APP-CHO cells [Chinese hamster ovarian (CHO) cells stably expressing amyloid precursor protein (APP)], as determined by an enzyme-linked immunosorbent assay and Western blot analysis. Then, the compounds isolated from C. dahurica were tested for their antiamyloidogenic activities. Four compounds (1\u20134) efficiently interrupted A\u03b2 generation by suppressing the level of \u03b2-secretase in APP-CHO cells. Moreover, the in vivo experimental results demonstrated that compound 4 improved the cognitive performances of mice with scopolamine-induced disruption on behavioral tests and the expression of memory-related proteins. Taken together, these results suggest that C. dahurica and its constituents are potential agents for preventing or alleviating the symptoms of AD.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.9b00543","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T16:47:51Z","timestamp":1581094071000},"page":"223-230","source":"Crossref","is-referenced-by-count":8,"title":["Protective Effects of Compounds from\n                    <i>Cimicifuga\ndahurica<\/i>\n                    against Amyloid Beta Production in Vitro and Scopolamine-Induced\nMemory Impairment in Vivo"],"prefix":"10.1021","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8539-0607","authenticated-orcid":true,"given":"Sang-Bin","family":"Lee","sequence":"first","affiliation":[{"name":"Korea Institute of Science and Technology , , , ,","place":["Gangneung, Gangwon-do, Republic of Korea, 25451"]},{"name":"Sungkyunkwan University , , ,","place":["Suwon, Republic of Korea, 16419"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-1374","authenticated-orcid":true,"given":"Seo Young","family":"Yang","sequence":"additional","affiliation":[{"name":"Chungnam National University , , ,","place":["Daejeon, Republic of Korea, 34134"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Phuong","family":"Thao","sequence":"additional","affiliation":[{"name":"Vietnam Academy of Science and Technology (VAST) , , 18-Hoang Quoc Viet , ,","place":["Hanoi, Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Gun","family":"Seo","sequence":"additional","affiliation":[{"name":"Dankook University , , Dongnam-gu , ,","place":["Cheonan, Korea, 31116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunggun","family":"Kim","sequence":"additional","affiliation":[{"name":"Dankook University , , Dongnam-gu , ,","place":["Cheonan, Korea, 31116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-3354","authenticated-orcid":true,"given":"Chi Thanh","family":"Ma","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology , , , ,","place":["Gangneung, Gangwon-do, Republic of Korea, 25451"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Young","family":"Park","sequence":"additional","affiliation":[{"name":"Dankook University , , Dongnam-gu , ,","place":["Cheonan, Korea, 31116"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5212-7543","authenticated-orcid":true,"given":"Young Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Chungnam National University , , ,","place":["Daejeon, Republic of Korea, 34134"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-0843","authenticated-orcid":true,"given":"Hyun Ok","family":"Yang","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology , , , ,","place":["Gangneung, Gangwon-do, Republic of Korea, 25451"]},{"name":"Korea University of Science and Technology , , ,","place":["Seoul, Republic\nof Korea, 02792"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"2026081719123028700_cit1","doi-asserted-by":"publisher","first-page":"815","DOI":"10.2147\/CIA.S134605","volume":"12","author":"Lakey-Beitia","year":"2017","journal-title":"Clin. 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