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A new oxidation product (8a) was also obtained from dobinin H (8). Their structures were elucidated by spectroscopic data and single-crystal X-ray diffraction analyses. Dobinins K\u2013N (12\u201315) are the first examples of rearrangement noreudesmane analogue sesquiterpenoids with a unique 6\/5-fused carbon skeleton. A putative biosynthetic pathway of compounds 12\u201315 is proposed. Compound 12 exhibited significant antimalarial activity superior to artemisinin with the inhibition ratio of 59.1%, and compounds 3, 5, and 15 exhibited moderate antimalarial activities against Plasmodium yoelii BY265RFP with inhibition ratios ranging from 14.5% to 18.5% at a dose of 30 mg\/kg\/day. In addition, the apoptosis of P. yoelii BY265RFP by the depolarization of mitochondrial membrane potential with striking ROS production, after parasitized erythrocyte lysis mediated by cytokines IL-12 and IFN-\u03b3, may be a possible mechanism of antimalarial action of compound 12 against P. yoelii BY265RFP.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.9b00761","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T13:13:02Z","timestamp":1585746782000},"page":"927-936","source":"Crossref","is-referenced-by-count":17,"title":["Antimalarial Eudesmane Sesquiterpenoids from\n                    <i>Dobinea delavayi<\/i>"],"prefix":"10.1021","volume":"83","author":[{"given":"Yi","family":"Shen","sequence":"first","affiliation":[{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]},{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Jun","family":"Cui","sequence":"additional","affiliation":[{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shen","sequence":"additional","affiliation":[{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Dong","sequence":"additional","affiliation":[{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]},{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5540-2339","authenticated-orcid":true,"given":"Chao-Jiang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4036-0735","authenticated-orcid":true,"given":"Bei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Dali University , , ,","place":["Dali, People\u2019s\nRepublic of China, 671000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"key":"2026081719170719700_cit1","unstructured":"World Health Organization\n          . 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