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Chemical profiles were determined by HPLC-DAD-MS\/MS data and evaluated using principal component analysis and hierarchical clustering analysis to discern chemical composition patterns. Based on phytogeographical origin and chemical composition, 20 potential markers were identified and five groups were distinguished: (I) Cerrado\/Central, (II) Atlantic Forest\/South, (III) Cerrado\u2013Pantanal transition area\/Northwest, (IV) Cerrado\/North, and (V) Pantanal\/West. Drawing on HPLC-DAD-MS\/MS and NMR data, 47 compounds were successfully or tentatively identified, including prenylated phenylpropanoids, flavonoids, isoflavonoids, and di- and triterpenoids, among other constituents. Isoflavonoids, typically found in red propolis from Northeast Brazil, are being reported for the first time in a propolis sample from the Midwest. A new prenylated aromatic compound, (E)-3-[4-hydroxy-3-(2-hydroxy-3-methylbut-3-en-1-yl)-5-(3-methylbut-2-en-1-yl)\u00adphenyl]\u00adpropenoic acid, was obtained. Samples in group II exhibited promising antitumor potential against prostate and breast carcinoma cells, as did samples in groups III and IV against the latter cell line. The sample in group I, despite containing the highest amount of total phenolic compounds and being the only sample to exhibit scavenging activity against DPPH, was not the most cytotoxic against the cell lines tested.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.9b00783","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T16:48:51Z","timestamp":1581094131000},"page":"333-343","source":"Crossref","is-referenced-by-count":38,"title":["Metabolomics Approach Expands the Classification of\nPropolis Samples from Midwest Brazil"],"prefix":"10.1021","volume":"83","author":[{"suffix":"Jr.","given":"Alberto\nG.","family":"Costa","sequence":"first","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul , , , ,","place":["Campo\nGrande, MS, Brazil, 79074-460"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni\u0301dia C.","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul , , , ,","place":["Campo\nGrande, MS, Brazil, 79074-460"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walmir S.","family":"Garcez","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul , , , ,","place":["Campo\nGrande, MS, Brazil, 79074-460"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2747-7039","authenticated-orcid":true,"given":"Renata T.","family":"Perdomo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul , , , ,","place":["Campo Grande, MS, Brazil, 79070-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Fa\u0301tima\nC.","family":"Matos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul , , , ,","place":["Campo Grande, MS, Brazil, 79070-900"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3995-4472","authenticated-orcid":true,"given":"Fernanda R.","family":"Garcez","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul , , , ,","place":["Campo\nGrande, MS, Brazil, 79074-460"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"2026081719092388300_cit1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0278-6915(97)00145-2","volume":"36","author":"Burdock","year":"1998","journal-title":"Food Chem. 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