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Their structures were elucidated based on extensive spectroscopic analysis and quantum chemical calculations. Notably, compounds 1\u20137 and 9 possess an unusual 17\u03b1-side chain, and 1\u20134, 6, and 9 contain an uncommon 3-methyl-5,6-dihydro-2H-pyran-2-one moiety in the side chain. Compounds 1\u20135 and 9 have a 3,19-hemiketal bridge in the A ring. In an in vivo bioassay, 1, 2, and 4\u20136 exhibited significant preventive effects on zebrafish heart failure at 0.5 \u03bcg\/mL, improving heart dilatation, venous congestion, cardiac output, blood flow velocity, and heart rate. Compound 5, displaying the most promising heart failure preventive activities, showed even better effects on increasing cardiac output (72%) and blood flow velocity (83%) than six first-line heart failure therapeutic drugs. Moreover, 1, 2, and 6 prevented the formation of thrombosis in zebrafish at 0.5 \u03bcg\/mL. The present investigation suggests that the new dammarane triterpenoids might be partially responsible for the utility of R. chinensis in treating coronary artery heart disease.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.9b00857","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T16:50:18Z","timestamp":1581094218000},"page":"362-373","source":"Crossref","is-referenced-by-count":21,"title":["Dammarane-Type Triterpenoids from the Roots of\n                    <i>Rhus chinensis<\/i>\n                    and Their Preventive Effects on Zebrafish\nHeart Failure and Thrombosis"],"prefix":"10.1021","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-2207","authenticated-orcid":true,"given":"Miao","family":"Ye","sequence":"first","affiliation":[{"name":"Fujian University of Traditional Chinese Medicine , , 1 QiuYang Road , Shangjie, ,","place":["Fuzhou, People\u2019s Republic of China, 350122"]},{"name":"Fujian University of Traditional Chinese 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