{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:05:14Z","timestamp":1789589114891,"version":"build-2803163510"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist?rio da Sa?de","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003545","name":"Minist?rio da Ci?ncia, Tecnologia e Inova??o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda??o Arauc?ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011875","name":"Minist?rio da Ci?ncia, Tecnologia, Inova??es e Comunica??es","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011875","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004611","name":"Secret?rio de Ci?ncia, Tecnologia e Ensino Superior, Governo do Estado de Parana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004611","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Estado do Paran?","award":["014\/2017"],"award-info":[{"award-number":["014\/2017"]}]},{"name":"State Health Secretariat, Paran?","award":["041\/2017"],"award-info":[{"award-number":["041\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Gram-negative bacterial infections induce inflammation and pain. Lipopolysaccharide (LPS) is a pathogen-associated molecular pattern and the major constituent of Gram-negative bacterial cell walls. Diosmin is a citrus flavonoid with antioxidant and anti-inflammatory activities. Here we investigated the efficacy of diosmin in a nonsterile model of inflammatory pain and peritonitis induced by LPS. Diosmin reduced in a dose-dependent manner LPS-induced inflammatory mechanical hyperalgesia, thermal hyperalgesia, and neutrophil recruitment to the paw (myeloperoxidase activity). Diosmin also normalized changes in paw weight distribution assessed by static weight bearing as a nonreflexive method of pain measurement. Moreover, treatment with diosmin inhibited LPS-induced peritonitis as observed by a reduction of leukocyte recruitment and oxidative stress. Diosmin reduced LPS-induced total ROS production (DCFDA assay) and superoxide anion production (NBT assay and NBT-positive cells). We also observed a reduction of LPS-induced oxidative stress and cytokine production (IL-1\u03b2, TNF-\u03b1, and IL-6) in the paw. Furthermore, we demonstrated that diosmin inhibited LPS-induced NF-\u03baB activation in peritoneal exudate. Thus, we demonstrated, using a model of nonsterile inflammation induced by LPS, that diosmin is a promising molecule for the treatment of inflammation and pain.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.9b00887","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T15:23:30Z","timestamp":1582298610000},"page":"1018-1026","source":"Crossref","is-referenced-by-count":44,"title":["Diosmin Treats Lipopolysaccharide-Induced Inflammatory\nPain and Peritonitis by Blocking NF-\u03baB Activation in Mice"],"prefix":"10.1021","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-7706","authenticated-orcid":true,"given":"Victor","family":"Fattori","sequence":"first","affiliation":[{"name":"Londrina State University , , , ,","place":["Londrina, Parana\u0301, Brazil, 86057-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda S.","family":"Rasquel-Oliveira","sequence":"additional","affiliation":[{"name":"Londrina State University , , , ,","place":["Londrina, Parana\u0301, Brazil, 86057-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara A.","family":"Artero","sequence":"additional","affiliation":[{"name":"Londrina State University , , , ,","place":["Londrina, Parana\u0301, Brazil, 86057-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila R.","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Londrina State University , , , ,","place":["Londrina, Parana\u0301, Brazil, 86057-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio M.","family":"Borghi","sequence":"additional","affiliation":[{"name":"Londrina State University , , , ,","place":["Londrina, Parana\u0301, Brazil, 86057-970"]},{"name":"University of Northern Parana\u0301 , , , ,","place":["Londrina, Parana\u0301, Brazil, 86057-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-1668","authenticated-orcid":true,"given":"Rubia","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Londrina State University , , , ,","place":["Londrina, Parana\u0301, Brazil, 86057-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-9283","authenticated-orcid":true,"suffix":"Jr.","given":"Waldiceu A.","family":"Verri","sequence":"additional","affiliation":[{"name":"Londrina State University , , , ,","place":["Londrina, Parana\u0301, Brazil, 86057-970"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,2,21]]},"reference":[{"issue":"1","key":"2026081719194200500_cit1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","article-title":"Nociceptor Sensory\nNeuron-Immune Interactions in Pain and Inflammation","volume":"38","author":"Pinho-Ribeiro","year":"2017","journal-title":"Trends Immunol."},{"issue":"1","key":"2026081719194200500_cit2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.pharmthera.2006.04.001","article-title":"Hypernociceptive\nrole of cytokines\nand chemokines: targets for analgesic drug development?","volume":"112","author":"Verri","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"2026081719194200500_cit3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jmb.2016.12.023","article-title":"Bacterial Signaling\nto the Nervous System via Toxins\nand Metabolites","volume":"429","author":"Yang","year":"2017","journal-title":"J. Mol. Biol."},{"issue":"3","key":"2026081719194200500_cit4","doi-asserted-by":"publisher","first-page":"e90013","DOI":"10.1371\/journal.pone.0090013","article-title":"Lipopolysaccharide induces inflammatory\nhyperalgesia\ntriggering a TLR4\/MyD88-dependent cytokine cascade in the mice paw","volume":"9","author":"Calil","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"2026081719194200500_cit5","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.pbb.2006.05.008","article-title":"Hypernociception\nelicited by tibio-tarsal joint flexion in mice: a novel experimental\narthritis model for pharmacological screening","volume":"84","author":"Guerrero","year":"2006","journal-title":"Pharmacol., Biochem. Behav."},{"issue":"47","key":"2026081719194200500_cit6","doi-asserted-by":"publisher","first-page":"E7572","DOI":"10.1073\/pnas.1606608113","article-title":"IL-33\/ST2 signaling excites sensory\nneurons and mediates itch response in a mouse model of poison ivy\ncontact allergy","volume":"113","author":"Liu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S.\nA."},{"issue":"1","key":"2026081719194200500_cit7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1523\/JNEUROSCI.3858-05.2006","article-title":"Acute p38-mediated modulation of tetrodotoxin-resistant\nsodium channels in mouse sensory neurons by tumor necrosis factor-alpha","volume":"26","author":"Jin","year":"2006","journal-title":"J. Neurosci."},{"key":"2026081719194200500_cit8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1744-8069-7-73","article-title":"Genetic evidence for\nan essential role of neuronally expressed IL-6\nsignal transducer gp130 in the induction and maintenance of experimentally\ninduced mechanical hypersensitivity in vivo and in vitro","volume":"7","author":"Quarta","year":"2011","journal-title":"Mol. Pain"},{"issue":"52","key":"2026081719194200500_cit9","doi-asserted-by":"publisher","first-page":"14062","DOI":"10.1523\/JNEUROSCI.3795-08.2008","article-title":"Nociceptors\nare interleukin-1beta sensors","volume":"28","author":"Binshtok","year":"2008","journal-title":"J. Neurosci."},{"issue":"2","key":"2026081719194200500_cit10","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1053\/gast.2000.9561","article-title":"Nonsteroidal\nanti-inflammatory drug gastropathy","volume":"119","author":"Hawkey","year":"2000","journal-title":"Gastroenterology"},{"key":"2026081719194200500_cit11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.phrs.2016.12.039","article-title":"Vinpocetine reduces\ndiclofenac-induced acute kidney injury through inhibition of oxidative\nstress, apoptosis, cytokine production, and NF-kappaB activation in\nmice","volume":"120","author":"Fattori","year":"2017","journal-title":"Pharmacol. Res."},{"issue":"2","key":"2026081719194200500_cit12","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/clc.22502","article-title":"Nonsteroidal\nAnti-inflammatory Drugs\nand Risk of Incident Heart Failure: A Systematic Review and Meta-analysis\nof Observational Studies","volume":"39","author":"Ungprasert","year":"2016","journal-title":"Clin. Cardiol."},{"key":"2026081719194200500_cit13","first-page":"297","article-title":"Flavonoids as\nAnti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives\nin the Development of Pharmaceutical Forms","volume-title":"Studies in Natural Products Chemistry","author":"Verri","year":"2012","edition":"1"},{"issue":"1","key":"2026081719194200500_cit14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1177\/1945892418809237","article-title":"Efficacy\nand Safety of Daflon\u00ad(R) in the Treatment of Idiopathic Epistaxis","volume":"33","author":"Attia","year":"2019","journal-title":"Am. J. Rhinol Allergy"},{"key":"2026081719194200500_cit15","doi-asserted-by":"publisher","first-page":"162750","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological\nactivities of flavonoids:\nan overview","volume":"2013","author":"Kumar","year":"2013","journal-title":"Sci. World J."},{"issue":"2","key":"2026081719194200500_cit16","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3945\/ajcn.111.016634","article-title":"Flavonoid intake and cardiovascular disease mortality\nin a prospective cohort of US adults","volume":"95","author":"McCullough","year":"2012","journal-title":"Am. J.\nClin. Nutr."},{"issue":"3","key":"2026081719194200500_cit17","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1093\/ajcn\/76.3.560","article-title":"Flavonoid intake and\nrisk of chronic diseases","volume":"76","author":"Knekt","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"issue":"4","key":"2026081719194200500_cit18","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.jpba.2009.09.012","article-title":"Simultaneous determination of diosmin\nand diosmetin in human plasma by ion trap liquid chromatography-atmospheric\npressure chemical ionization tandem mass spectrometry: Application\nto a clinical pharmacokinetic study","volume":"51","author":"Campanero","year":"2010","journal-title":"J. Pharm.\nBiomed. Anal."},{"issue":"5","key":"2026081719194200500_cit19","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1007\/s10753-016-0413-4","article-title":"Diosmin Modulates\nthe NF-kB Signal Transduction Pathways and Downregulation of Various\nOxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy","volume":"39","author":"Ahmed","year":"2016","journal-title":"Inflammation"},{"key":"2026081719194200500_cit20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.phrs.2015.09.001","article-title":"Diosmin downregulates the expression\nof T cell receptors, pro-inflammatory cytokines and NF-kappaB activation\nagainst LPS-induced acute lung injury in mice","volume":"102","author":"Imam","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"3","key":"2026081719194200500_cit21","doi-asserted-by":"publisher","first-page":"e0122417","DOI":"10.1371\/journal.pone.0122417","article-title":"Diosmin\nprotects against ethanol-induced gastric injury in rats: novel anti-ulcer\nactions","volume":"10","author":"Arab","year":"2015","journal-title":"PLoS One"},{"key":"2026081719194200500_cit22","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cbi.2017.06.014","article-title":"Diosmin reduces chronic constriction\ninjury-induced neuropathic pain\nin mice","volume":"273","author":"Bertozzi","year":"2017","journal-title":"Chem.-Biol. Interact."},{"key":"2026081719194200500_cit23","doi-asserted-by":"publisher","first-page":"8263463","DOI":"10.1155\/2016\/8263463","article-title":"Antihyperalgesic\nEffect of Hesperidin Improves with Diosmin in Experimental Neuropathic\nPain","volume":"2016","author":"Carballo-Villalobos","year":"2016","journal-title":"BioMed Res. Int."},{"issue":"4","key":"2026081719194200500_cit24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1053\/ejvs.1998.0751","article-title":"Endothelial\nactivation response to oral micronised flavonoid therapy in patients\nwith chronic venous disease--a prospective study","volume":"17","author":"Shoab","year":"1999","journal-title":"Eur. J. Vasc Endovasc Surg"},{"key":"2026081719194200500_cit25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1159\/000054071","article-title":"Neutrophil\nactivation and mediators of inflammation in chronic venous insufficiency","volume":"36","author":"Smith","year":"1999","journal-title":"J. Vasc. Res."},{"issue":"5","key":"2026081719194200500_cit26","first-page":"428","article-title":"Analysis of the effects of micronized\npurified flavonoid fraction versus placebo on symptoms and quality\nof life in patients suffering from chronic venous disease: from a\nprospective randomized trial","volume":"34","author":"Rabe","year":"2015","journal-title":"Int. Angiol"},{"issue":"2","key":"2026081719194200500_cit27","first-page":"96","article-title":"Effects of\nmicronized purified flavonoid\nfraction (Daflon) on pelvic pain in women with laparoscopically diagnosed\npelvic congestion syndrome: a randomized crossover trial","volume":"34","author":"Simsek","year":"2007","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"3","key":"2026081719194200500_cit28","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1590\/S0100-879X2004000300018","article-title":"An electronic\npressure-meter nociception paw test for mice","volume":"37","author":"Cunha","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"2","key":"2026081719194200500_cit29","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1213\/ane.0b013e3181aa956b","article-title":"Long-term pain vulnerability\nafter surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic\nproperties","volume":"109","author":"Laboureyras","year":"2009","journal-title":"Anesth. Analg."},{"key":"2026081719194200500_cit30","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1111\/bph.14647","article-title":"The specialized\npro-resolving lipid mediator Maresin-1 reduces inflammatory pain with\na long-lasting analgesic effect","volume":"176","author":"Fattori","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"2026081719194200500_cit31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cbi.2015.05.007","article-title":"Vinpocetine reduces\nlipopolysaccharide-induced inflammatory pain and neutrophil recruitment\nin mice by targeting oxidative stress, cytokines and NF-kappaB","volume":"237","author":"Ruiz-Miyazawa","year":"2015","journal-title":"Chem.-Biol. Interact."},{"key":"2026081719194200500_cit32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/1061186X.2016.1245308","article-title":"Differential\nregulation of oxidative\nstress and cytokine production by endothelin ETA and ETB receptors\nin superoxide anion-induced inflammation and pain in mice","volume":"25","author":"Fattori","year":"2017","journal-title":"J. Drug Target"},{"issue":"2","key":"2026081719194200500_cit33","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1021\/np300670w","article-title":"Quercetin-loaded microcapsules ameliorate experimental\ncolitis in mice by anti-inflammatory and antioxidant mechanisms","volume":"76","author":"Guazelli","year":"2013","journal-title":"J. Nat. Prod."},{"issue":"4","key":"2026081719194200500_cit34","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1097\/j.pain.0000000000000458","article-title":"Ensuring transparency\nand minimization of methodologic bias in preclinical pain research:\nPPRECISE considerations","volume":"157","author":"Andrews","year":"2016","journal-title":"Pain"},{"issue":"11","key":"2026081719194200500_cit35","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/nm.2230","article-title":"Overcoming\nobstacles to developing new analgesics","volume":"16","author":"Woolf","year":"2010","journal-title":"Nat.\nMed."},{"issue":"3","key":"2026081719194200500_cit36","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"2026081719194200500_cit37","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1189\/jlb.0907654","article-title":"Crucial role of\nneutrophils in the development of mechanical\ninflammatory hypernociception","volume":"83","author":"Cunha","year":"2008","journal-title":"J. Leukocyte\nBiol."},{"key":"2026081719194200500_cit38","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.phrs.2016.01.027","article-title":"Neutrophils and\narthritis: Role in disease and pharmacological perspectives","volume":"112","author":"Fattori","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"12","key":"2026081719194200500_cit39","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.tins.2016.10.003","article-title":"Nitroxidative Signaling Mechanisms\nin Pathological Pain","volume":"39","author":"Grace","year":"2016","journal-title":"Trends Neurosci."},{"issue":"5","key":"2026081719194200500_cit40","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.freeradbiomed.2011.01.026","article-title":"Roles of reactive\noxygen and nitrogen species in pain","volume":"51","author":"Salvemini","year":"2011","journal-title":"Free Radical\nBiol. Med."},{"key":"2026081719194200500_cit41","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neuroscience.2013.03.032","article-title":"Neuroprotection\ninduced by N-acetylcysteine against\ncytosolic glutathione depletion-induced Ca2+ influx in dorsal root\nganglion neurons of mice: role of TRPV1 channels","volume":"242","author":"Naziroglu","year":"2013","journal-title":"Neuroscience"},{"issue":"4","key":"2026081719194200500_cit42","doi-asserted-by":"publisher","first-page":"371","DOI":"10.4196\/kjpp.2017.21.4.371","article-title":"Reactive\noxygen species increase\nneuronal excitability via activation of nonspecific cation channel\nin rat medullary dorsal horn neurons","volume":"21","author":"Lee","year":"2017","journal-title":"Korean\nJ. Physiol. Pharmacol."},{"issue":"4","key":"2026081719194200500_cit43","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1590\/1414-431x20144187","article-title":"The superoxide anion donor, potassium\nsuperoxide, induces pain and inflammation in mice through production\nof reactive oxygen species and cyclooxygenase-2","volume":"48","author":"Maioli","year":"2015","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"12","key":"2026081719194200500_cit44","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s00011-015-0885-y","article-title":"Curcumin inhibits\nsuperoxide anion-induced\npain-like behavior and leukocyte recruitment by increasing Nrf2 expression\nand reducing NF-kappaB activation","volume":"64","author":"Fattori","year":"2015","journal-title":"Inflammation\nRes."},{"issue":"4","key":"2026081719194200500_cit45","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1096\/fj.12-221218","article-title":"Superoxide\ngeneration\nand leukocyte accumulation: key elements in the mediation of leukotriene\nB(4)-induced itch by transient receptor potential ankyrin 1 and transient\nreceptor potential vanilloid 1","volume":"27","author":"Fernandes","year":"2013","journal-title":"FASEB J."},{"issue":"8","key":"2026081719194200500_cit46","doi-asserted-by":"publisher","first-page":"3546","DOI":"10.1073\/pnas.0914351107","article-title":"Small-molecule screen identifies\nreactive oxygen species as key regulators of neutrophil chemotaxis","volume":"107","author":"Hattori","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"2026081719194200500_cit47","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.cellsig.2007.01.020","article-title":"TNF-alpha-induced\nNF-kappaB\/RelA Ser(276) phosphorylation and enhanceosome formation\nis mediated by an ROS-dependent PKAc pathway","volume":"19","author":"Jamaluddin","year":"2007","journal-title":"Cell. Signalling"},{"issue":"3","key":"2026081719194200500_cit48","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1074\/jbc.M106393200","article-title":"Peroxynitrite is an essential component\nof cytokines\nproduction mechanism in human monocytes through modulation of nuclear\nfactor-kappa B DNA binding activity","volume":"277","author":"Matata","year":"2002","journal-title":"J. Biol.\nChem."},{"issue":"2\u20133","key":"2026081719194200500_cit49","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s10787-016-0266-3","article-title":"Pyrrolidine dithiocarbamate\ninhibits superoxide anion-induced pain and inflammation in the paw\nskin and spinal cord by targeting NF-kappaB and oxidative stress","volume":"24","author":"Pinho-Ribeiro","year":"2016","journal-title":"Inflammopharmacology"},{"issue":"3","key":"2026081719194200500_cit50","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.toxlet.2013.04.004","article-title":"Diosmin abrogates chemically induced\nhepatocarcinogenesis\nvia alleviation of oxidative stress, hyperproliferative and inflammatory\nmarkers in murine model","volume":"220","author":"Tahir","year":"2013","journal-title":"Toxicol. Lett."},{"issue":"1","key":"2026081719194200500_cit51","first-page":"29","article-title":"Pharmacokinetics and metabolism of oral diosmin in\nhealthy volunteers","volume":"30","author":"Cova","year":"1992","journal-title":"Int. J. Clin Pharmacol Ther\nToxicol"},{"issue":"3","key":"2026081719194200500_cit52","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/bmc.1090","article-title":"The phytochemical analysis and antioxidant activity\nassessment of orange peel (Citrus sinensis) cultivated in Greece-Crete\nindicates a new commercial source of hesperidin","volume":"23","author":"Kanaze","year":"2009","journal-title":"Biomed. Chromatogr."},{"issue":"4","key":"2026081719194200500_cit53","doi-asserted-by":"publisher","first-page":"315","DOI":"10.4149\/gpb_2019010","article-title":"Diosmin suppresses\nthe proinflammatory mediators in lipopolysaccharide-induced RAW264.7\nmacrophages via NF-kappaB and MAPKs signal pathways","volume":"38","author":"Berkoz","year":"2019","journal-title":"Gen Physiol Biophys"},{"issue":"7","key":"2026081719194200500_cit54","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1039\/C6PP00442C","article-title":"trans-Chalcone,\na flavonoid precursor,\ninhibits UV-induced skin inflammation and oxidative stress in mice\nby targeting NADPH oxidase and cytokine production","volume":"16","author":"Martinez","year":"2017","journal-title":"Photochem. Photobiol. Sci."},{"key":"2026081719194200500_cit55","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.3389\/fphar.2018.01123","article-title":"Trans-Chalcone Attenuates Pain and\nInflammation in Experimental Acute Gout Arthritis in Mice","volume":"9","author":"Staurengo-Ferrari","year":"2018","journal-title":"Front. 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