{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:28:38Z","timestamp":1787041718880,"version":"build-2736575974"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001655","name":"Deutscher Akademischer Austauschdienst","doi-asserted-by":"publisher","award":["91635080"],"award-info":[{"award-number":["91635080"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Phytochemical analysis of a methanol\u2013dichloromethane (1:1) extract of the aerial parts of Tephrosialinearis led to the isolation of 18 compounds. Seven of these, namely, lineaflavones A\u2013D (1\u20134), 6-methoxygeraldone (5), 8\u2033-acetylobovatin (6), and 5-hydroxy-7-methoxysaniculamin A (7) are new compounds. The compounds were characterized based on their NMR and HRMSn data. The anti-inflammatory effects of the crude extract and isolated compounds were evaluated by measuring the levels of interleukins (IL-1\u03b2, IL-2, and IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-\u03b1 (TNF-\u03b1) in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). The crude extract inhibited the release of all cytokines except IL-1\u03b2, which slightly increased in comparison to the LPS control. All the tested compounds suppressed the production of IL-2, GM-CSF, and TNF-\u03b1. Whereas compounds 1, 2, 4\u20138, 10\u201315, 17, and 18 decreased production of IL-6, compounds 1, 2, 4, 7, 10, 13\u201315, and 17 inhibited the release of IL-1\u03b2. It is worth noting that most of the compounds tested showed a superior reduction in cytokines release compared to the reference drug ibuprofen.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.9b00922","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T12:47:32Z","timestamp":1583844452000},"page":"996-1004","source":"Crossref","is-referenced-by-count":22,"title":["Anti-inflammatory Flavanones and Flavones from\n                    <i>Tephrosia linearis<\/i>"],"prefix":"10.1021","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-8833","authenticated-orcid":true,"given":"Richard\nOriko","family":"Owor","sequence":"first","affiliation":[{"name":"University of Nairobi , , P.O. Box 30197-00100, ,","place":["Nairobi, Kenya"]},{"name":"TU Dortmund , , Otto-Hahn-Strasse 6 , ,","place":["Dortmund, Germany, 44221"]},{"name":"Busitema University , , P.O. Box 236, ,","place":["Tororo, Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kibrom Gebreheiwot","family":"Bedane","sequence":"additional","affiliation":[{"name":"TU Dortmund , , Otto-Hahn-Strasse 6 , ,","place":["Dortmund, Germany, 44221"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zu\u0308hlke","sequence":"additional","affiliation":[{"name":"TU Dortmund , , Otto-Hahn-Strasse 6 , ,","place":["Dortmund, Germany, 44221"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-3583","authenticated-orcid":true,"given":"Solomon","family":"Derese","sequence":"additional","affiliation":[{"name":"University of Nairobi , , P.O. 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