{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:49:08Z","timestamp":1791002948789,"version":"4.1.0"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K08319"],"award-info":[{"award-number":["16K08319"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human pancreatic cancer is one of the most aggressive types of cancer, with a high mortality rate. Due to the high tolerance of such cancer cells to nutrient starvation conditions, they can survive in a hypovascular tumor microenvironment. In this study, the dichloromethane extract of the roots of Ferula hezarlalehzarica showed potent preferential cytotoxic activity with a PC50 value of 0.78 \u03bcg\/mL. Phytochemical investigation of this extract led to the isolation of 18 compounds, including one new sesquiterpenoid (6) and one new monoterpenoid (18). All isolated compounds were evaluated for their preferential cytotoxicity against PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. Among them, ferutinin (2) was identified as the most active compound, with a PC50 value of 0.72 \u03bcM. In addition, the real-time effect of ferutinin (2) and compound 6 against PANC-1 cells, exposed to a nutrient-deprived medium (NDM), showed cell shrinkage, leading to cancer cell death within a short period of exposure. Compounds 2 and 6 also inhibited colony formation of PANC-1 cells. The present study indicates that the dichloromethane extract of the roots of F. hezarlalehzarica is a rich source of bioactive compounds for targeting PANC-1 cells.<\/jats:p>","DOI":"10.1021\/acs.jnatprod.9b01109","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T16:22:11Z","timestamp":1584030131000},"page":"1099-1106","source":"Crossref","is-referenced-by-count":23,"title":["Antiausterity Activity of Secondary Metabolites from\nthe Roots of\n                    <i>Ferula hezarlalehzarica<\/i>\n                    against the\nPANC-1 Human Pancreatic Cancer Cell Line"],"prefix":"10.1021","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-6720","authenticated-orcid":true,"given":"Mostafa","family":"Alilou","sequence":"first","affiliation":[{"name":"University of Innsbruck , , Innrain 80\/82 , ,","place":["Innsbruck, Austria, 6020"]},{"name":"Innsbruck Medical University , , Innrain 66 , ,","place":["Innsbruck, Austria, A-6020"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dya Fita","family":"Dibwe","sequence":"additional","affiliation":[{"name":"University of Toyama , , 2630 Sugitani , ,","place":["Toyama, Japan, 930-0194"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3731-7349","authenticated-orcid":true,"given":"Stefan","family":"Schwaiger","sequence":"additional","affiliation":[{"name":"University of Innsbruck , , Innrain 80\/82 , ,","place":["Innsbruck, Austria, 6020"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Khodami","sequence":"additional","affiliation":[{"name":"Kerman University of Medical Science , , ,","place":["Kerman, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Troppmair","sequence":"additional","affiliation":[{"name":"Innsbruck Medical University , , Innrain 66 , ,","place":["Innsbruck, Austria, A-6020"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-193X","authenticated-orcid":true,"given":"Suresh","family":"Awale","sequence":"additional","affiliation":[{"name":"University of Toyama , , 2630 Sugitani , ,","place":["Toyama, Japan, 930-0194"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Stuppner","sequence":"additional","affiliation":[{"name":"University of Innsbruck , , Innrain 80\/82 , ,","place":["Innsbruck, Austria, 6020"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2020,3,12]]},"reference":[{"key":"2026090116065418300_cit1","doi-asserted-by":"publisher","first-page":"e3154","DOI":"10.1038\/cddis.2017.525","volume":"8","author":"Yan","year":"2017","journal-title":"Cell Death Dis."},{"key":"2026090116065418300_cit2","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14740\/wjon1166","volume":"10","author":"Rawla","year":"2019","journal-title":"World J. 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