{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:22:23Z","timestamp":1788438143536,"version":"build-2803163510"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2021,8,6]]},"DOI":"10.1021\/acs.joc.1c01258","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T12:50:35Z","timestamp":1626699035000},"page":"10608-10620","source":"Crossref","is-referenced-by-count":21,"title":["Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid"],"prefix":"10.1021","volume":"86","author":[{"given":"Patr\u00edcia S. M.","family":"Amado","sequence":"first","affiliation":[{"name":"Center of Marine Sciences (CCMAR), University of Algarve, P-8005-039 Faro, Portugal"},{"name":"Department of Chemistry and Pharmacy, FCT, University of Algarve, P-8005-039 Faro, Portugal"},{"name":"Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3252-3482","authenticated-orcid":true,"given":"Lu\u00eds M. T.","family":"Frija","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural (CQE), Instituto Superior T\u00e9cnico, University of Lisbon, Av. Rovisco Pais, 1049-001 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-0993","authenticated-orcid":true,"given":"Jaime A. S.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural (CQE), Faculdade de Ci\u00eancias, University of Lisbon,\rCampo Grande, 1749-016 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4338-0317","authenticated-orcid":true,"given":"Paul M.","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-2855","authenticated-orcid":true,"given":"Maria L. S.","family":"Cristiano","sequence":"additional","affiliation":[{"name":"Center of Marine Sciences (CCMAR), University of Algarve, P-8005-039 Faro, Portugal"},{"name":"Department of Chemistry and Pharmacy, FCT, University of Algarve, P-8005-039 Faro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2011183215"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(08)61492-0"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01115-10"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-016-0611-9"},{"key":"ref5\/cit5","volume-title":"Guidelines for the Treatment of Malaria, 2021","author":"WHO","year":"2021"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","unstructured":"Rawe, S. L. Artemisinin and Artemisinin-Related Agents; Elsevier Ltd, 2020; pp 99\u2013132.","DOI":"10.1016\/B978-0-08-101210-9.00004-4"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1314981"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0808859"},{"key":"ref9\/cit9","unstructured":"WHO.  Status Report on Artemisinin and ACT Resistance, December 2019."},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00527"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/jm030571c"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/med.10066"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/med.20223"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nature02779"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1015762108"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(15)00320-5"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201001026"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2016.08.043"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15159"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcata.2006.12.029"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b02191"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2011.610549"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1039\/c3ra42513d"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/s0040-4039(03)01472-2"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.01.103"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/ol8023874"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1289864"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2012.07.001"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.24297\/jac.v11i3.866"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3184\/174751916x14792244600532"},{"key":"ref31\/cit31","first-page":"11","volume":"7","author":"Khosravi K.","year":"2017","journal-title":"Iran. J. Catal."},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201904555"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1246\/cl.1989.573"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)00791-2"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1080\/10426500490459722"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1590\/s0103-50532008000800020"},{"key":"ref37\/cit37","unstructured":"Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G. A.; Nakatsuji, H.; Caricato, M.; Li, X.; Hratchian, H. P.; Izmaylov, A. F.; Bloino, J.; Zheng, G.; Sonnenberg, J. L.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Peralta, J. E.; Ogliaro, F.; Bearpark, M.; Heyd, J. J.; Brothers, E.; Kudin, K. N.; Staroverov, V. N.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Rega, N.; Millam, J. M.; Klene, M.; Knox, J. E.; Cross, J. B.; Bakken, V.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R. E.; Yazyev, O.; Austin, A. J.; Cammi, R.; Pomelli, C.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Zakrzewski, V. G.; Voth, G. A.; Salvador, P.; Dannenberg, J. J.; Dapprich, S.; Daniels, A. D.; Farkas, \u00d6.; Foresman, J. B.; Ortiz, J. V.; Cioslowski, J.; Fox, D. J. GAUSSIAN 09, Revision D.01; Gaussian, Inc.: Wallingford CT, 2009."},{"key":"ref38\/cit38","unstructured":"Legault, C. Y. CYLview, 1.0b; Universit\u00e9 de Sherbrooke, 2009. http:\/\/www.cylview.org."},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/b810189b"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1063\/1.474659"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-2614(98)00106-7"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1063\/1.473558"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/cr9904009"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/jp810292n"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2007.03.165"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2003.09.033"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.09.052"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/s0040-4020(00)00850-4"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1039\/c1md00102g"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300202"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201810757"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200700975"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.1c01258","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T08:55:35Z","timestamp":1682585735000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.1c01258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,19]]},"references-count":52,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2021,8,6]]}},"alternative-id":["10.1021\/acs.joc.1c01258"],"URL":"https:\/\/doi.org\/10.1021\/acs.joc.1c01258","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,19]]}}}