{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:49:35Z","timestamp":1790689775393,"version":"4.1.0"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"18","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010067","name":"Gobierno de Arag??n","doi-asserted-by":"publisher","award":["E34_20R"],"award-info":[{"award-number":["E34_20R"]}],"id":[{"id":"10.13039\/501100010067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell???Istruzione, dell???Universit?? e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom??a y Competitividad","doi-asserted-by":"publisher","award":["CTQ2016-77270-R"],"award-info":[{"award-number":["CTQ2016-77270-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom??a y Competitividad","doi-asserted-by":"publisher","award":["PID2019-104090RB-100"],"award-info":[{"award-number":["PID2019-104090RB-100"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007387","name":"Fondazione Cassa di Risparmio di Pistoia e Pescia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009888","name":"Regione Toscana","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009888","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015694","name":"Fondazione Cassa di Risparmio di Firenze","doi-asserted-by":"publisher","award":["2018.0942"],"award-info":[{"award-number":["2018.0942"]}],"id":[{"id":"10.13039\/501100015694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004434","name":"Universit?? degli Studi di Firenze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2021,9,17]]},"DOI":"10.1021\/acs.joc.1c01308","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T12:11:56Z","timestamp":1630498316000},"page":"12745-12761","source":"Crossref","is-referenced-by-count":23,"title":["Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)"],"prefix":"10.1021","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-0836","authenticated-orcid":true,"given":"Francesca","family":"Clemente","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica \u201cUgo Schiff\u201d (DICUS), University of Firenze, Via Della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-383X","authenticated-orcid":true,"given":"Camilla","family":"Matassini","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica \u201cUgo Schiff\u201d (DICUS), University of Firenze, Via Della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Giachetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica \u201cUgo Schiff\u201d (DICUS), University of Firenze, Via Della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1081-533X","authenticated-orcid":true,"given":"Andrea","family":"Goti","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica \u201cUgo Schiff\u201d (DICUS), University of Firenze, Via Della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Morrone","sequence":"additional","affiliation":[{"name":"Paediatric Neurology Unit and Laboratories, Neuroscience Department, Meyer Children\u2019s Hospital, and Department of Neurosciences, Pharmacology and Child Health, University of Florence, Viale Pieraccini n. 24, 50139 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Mart\u00ednez-Bail\u00e9n","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica \u201cUgo Schiff\u201d (DICUS), University of Firenze, Via Della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Qu\u00edmica, Universidad de Sevilla, c\/ Prof. Garc\u00eda Gonz\u00e1lez 1, E-41012 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Orta","sequence":"additional","affiliation":[{"name":"Unidad de Glicobiolog\u00eda, Instituto de Biocomputaci\u00f3n y F\u00edsica de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2202-3460","authenticated-orcid":true,"given":"Pedro","family":"Merino","sequence":"additional","affiliation":[{"name":"Unidad de Glicobiolog\u00eda, Instituto de Biocomputaci\u00f3n y F\u00edsica de Sistemas Complejos (BIFI), Universidad de Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-4624","authenticated-orcid":true,"given":"Francesca","family":"Cardona","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica \u201cUgo Schiff\u201d (DICUS), University of Firenze, Via Della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2021,9,1]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","DOI":"10.1002\/9780470517437","volume-title":"Iminosugars: From Synthesis to Therapeutic Applications","author":"Compain P.","year":"2007"},{"key":"ref2\/cit2a","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2014.916280"},{"key":"ref2\/cit2b","doi-asserted-by":"publisher","DOI":"10.1039\/9781849734769-00215"},{"key":"ref3\/cit3a","doi-asserted-by":"publisher","DOI":"10.1039\/d1ob00382h"},{"key":"ref3\/cit3b","doi-asserted-by":"publisher","DOI":"10.2174\/187231309789054878"},{"key":"ref3\/cit3c","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwi076"},{"key":"ref3\/cit3d","doi-asserted-by":"publisher","DOI":"10.2174\/1568026033452474"},{"key":"ref3\/cit3e","doi-asserted-by":"publisher","DOI":"10.1021\/cr990292q"},{"key":"ref4\/cit4a","doi-asserted-by":"publisher","DOI":"10.1021\/jm301557k"},{"key":"ref4\/cit4b","doi-asserted-by":"publisher","DOI":"10.1039\/c7sc04712f"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1039\/c6cc01564f"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.192582899"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200502662"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200600217"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.2174\/15701794113106660074"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-12-381290-2.00004-5"},{"key":"ref9\/cit9c","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2009.03.013"},{"key":"ref9\/cit9d","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2009.02.048"},{"key":"ref9\/cit9e","doi-asserted-by":"publisher","DOI":"10.2174\/1385272043370005"},{"key":"ref9\/cit9f","doi-asserted-by":"publisher","DOI":"10.2174\/1385272024605069"},{"key":"ref9\/cit9g","doi-asserted-by":"publisher","DOI":"10.1039\/c1ra00910a"},{"key":"ref9\/cit9h","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1099-0690(199905)1999:5<959::aid-ejoc959>3.0.co;2-k"},{"key":"ref9\/cit9i","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201500321"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201901840"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201200587"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201500292"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1588457"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1039\/c7ob01848g"},{"key":"ref15\/cit15a","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-6269"},{"key":"ref15\/cit15b","doi-asserted-by":"publisher","DOI":"10.1016\/j.crci.2005.02.013"},{"key":"ref15\/cit15c","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-6555"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00602"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.103740"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio850"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2007.06.029"},{"key":"ref20\/cit20a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00476"},{"key":"ref20\/cit20b","unstructured":"bMerino, P.\n                      Nitrones and its Cyclic Analogues\n                      ; Bellus, D., Padwa, A., Eds. George Thieme: Stuttgart, 2004; Vol. 27, pp 511\u2013580."},{"key":"ref20\/cit20c","unstructured":"cMerino, P.\n                      Nitrones and cyclic analogues\n                      . An update; Schaumann, E., Ed. George Thieme: Stuttgart, 2011; Vol. 2010\/4, pp 325\u2013403."},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ol062862w"},{"key":"ref22\/cit22a","doi-asserted-by":"publisher","DOI":"10.1021\/jo00293a013"},{"key":"ref22\/cit22b","doi-asserted-by":"publisher","DOI":"10.1016\/s0040-4039(00)96130-6"},{"key":"ref22\/cit22c","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(96)01266-x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.200700156"},{"key":"ref24\/cit24a","unstructured":"aAdolfsson, H.\n                      Modern Oxidation Methods\n                      ; Wiley-VCH: Weinheim, 2004; pp 32\u201343. and references therein."},{"key":"ref24\/cit24b","doi-asserted-by":"publisher","DOI":"10.1002\/ange.19911031234"},{"key":"ref24\/cit24b1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199116381"},{"key":"ref24\/cit24c","doi-asserted-by":"publisher","DOI":"10.1016\/0304-5102(93)e0162-a"},{"key":"ref24\/cit24d","doi-asserted-by":"publisher","DOI":"10.1021\/ar9601398"},{"key":"ref24\/cit24e","doi-asserted-by":"publisher","DOI":"10.1039\/a809222b"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b02029"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201901081"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00055"},{"key":"ref30\/cit30a","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3495(98)77735-5"},{"key":"ref30\/cit30b","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(83)90004-7"},{"key":"ref30\/cit30c","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(83)90524-2"},{"key":"ref30\/cit30d","doi-asserted-by":"publisher","DOI":"10.1042\/bj20020466"},{"key":"ref30\/cit30e","doi-asserted-by":"publisher","DOI":"10.1042\/bj20030348"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.1c01308","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.1c01308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T15:04:48Z","timestamp":1682607888000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.1c01308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,1]]},"references-count":57,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2021,9,17]]}},"alternative-id":["10.1021\/acs.joc.1c01308"],"URL":"https:\/\/doi.org\/10.1021\/acs.joc.1c01308","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,1]]}}}