{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:16:48Z","timestamp":1760267808118,"version":"3.40.5"},"reference-count":54,"publisher":"American Chemical Society (ACS)","issue":"15","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA216919"],"award-info":[{"award-number":["CA216919"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2022,8,5]]},"DOI":"10.1021\/acs.joc.2c00948","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T14:30:21Z","timestamp":1658932221000},"page":"9940-9956","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis and Evaluation of Simplified Cruentaren A Analogues"],"prefix":"10.1021","volume":"87","author":[{"given":"Xiaozheng","family":"Dou","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Notre Dame, Notre Dame, Indiana 46556, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhargav A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Notre Dame, Notre Dame, Indiana 46556, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terin","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Notre Dame, Notre Dame, Indiana 46556, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chitra","family":"Subramanian","sequence":"additional","affiliation":[{"name":"General Surgery Clinic, University of Michigan, Ann Arbor, Michigan 48109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Cousineau","sequence":"additional","affiliation":[{"name":"General Surgery Clinic, University of Michigan, Ann Arbor, Michigan 48109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Yi","sequence":"additional","affiliation":[{"name":"Global Blood Therapeutics, San Francisco, California 94080, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Cohen","sequence":"additional","affiliation":[{"name":"General Surgery Clinic, University of Michigan, Ann Arbor, Michigan 48109, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6200-3480","authenticated-orcid":true,"given":"Brian S. J.","family":"Blagg","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Notre Dame, Notre Dame, Indiana 46556, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1657"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00504"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2479"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2016.1272757"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200600421"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2006.89"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.06.069"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1021\/cb400906e"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.04.104"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.2174\/138161213804143725"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9258(20)80556-0"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-7258(98)00013-8"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2918"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.r800007200"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.2174\/156802609789895656"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1716"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nature01913"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-06-2966"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29339"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.653"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.59.7328"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-018-0877-2"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4040"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cancerbio-030518-055533"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.11.015"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2004.12.011"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/jm8007486"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m109.051532"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m112.427328"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200701673"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200701423"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/ol0629317"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200703839"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200901817"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/jo300225z"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1021\/ol302999v"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2017.05.034"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2010.04.068"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2014.01.097"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/ol0476164"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1021\/ja043612i"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.15227\/orgsyn.060.0041","volume":"60","author":"Hopf H.","year":"1981","journal-title":"Org. Synth."},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201001378"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/ja00113a031"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.04.101"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.354"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/ja00052a018"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/ja00370a050"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.15227\/orgsyn.068.0083","volume":"68","author":"Gage J. R.","year":"1990","journal-title":"Org. Synth."},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/om00088a019"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3998\/ark.5550190.0008.c10","volume":"2007","author":"Roberge J. Y.","year":"2007","journal-title":"Arkivoc"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.8b00961"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.24820\/ark.5550190.p010.819"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201804988"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.2c00948","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.2c00948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T17:14:29Z","timestamp":1682442869000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.2c00948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":54,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2022,8,5]]}},"alternative-id":["10.1021\/acs.joc.2c00948"],"URL":"https:\/\/doi.org\/10.1021\/acs.joc.2c00948","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"type":"print","value":"0022-3263"},{"type":"electronic","value":"1520-6904"}],"subject":[],"published":{"date-parts":[[2022,7,27]]}}}