{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:41:22Z","timestamp":1775558482965,"version":"3.50.1"},"reference-count":65,"publisher":"American Chemical Society (ACS)","issue":"13","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SPG\/2021\/004179"],"award-info":[{"award-number":["SPG\/2021\/004179"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR31944\/MED\/29\/1408\/2019"],"award-info":[{"award-number":["BT\/PR31944\/MED\/29\/1408\/2019"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Org. Chem."],"published-print":{"date-parts":[[2023,7,7]]},"DOI":"10.1021\/acs.joc.3c00754","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T19:26:38Z","timestamp":1685993198000},"page":"9105-9122","source":"Crossref","is-referenced-by-count":6,"title":["Multistep Synthesis of Analogues of Remdesivir: Incorporating Heterocycles at the C-1\u2032 Position"],"prefix":"10.1021","volume":"88","author":[{"given":"Savio","family":"Cardoza","sequence":"first","affiliation":[{"name":"Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj Kumar","family":"Shrivash","sequence":"additional","affiliation":[{"name":"Department of Applied Sciences, Indian Institute of Information Technology Allahabad, Allahabad 211012, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Riva","sequence":"additional","affiliation":[{"name":"Calibr, Scripps Research, La Jolla, 11119 North Torrey Pines Road Suite 100, California 92037, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5171-7982","authenticated-orcid":true,"given":"Arnab K.","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Calibr, Scripps Research, La Jolla, 11119 North Torrey Pines Road Suite 100, California 92037, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Mandal","sequence":"additional","affiliation":[{"name":"Symbol Discovery Ltd, ASPIRE-TBI, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad 500046, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6146-937X","authenticated-orcid":true,"given":"Vibha","family":"Tandon","sequence":"additional","affiliation":[{"name":"Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"ref1\/cit1a","first-page":"289","volume-title":"Molecular Virology of Human Pathogenic Viruses","author":"Ryu W. S.","year":"2017"},{"key":"ref1\/cit1b","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00646"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2023184"},{"key":"ref3\/cit3","unstructured":"WHO Recommends Highly Successful COVID-19\nTherapy and Calls for Wide\nGeographical Distribution and Transparency from Originator, 2022. https:\/\/www.who.int\/news\/item\/22-04-2022-who-recommends-highly-successful-covid-19-therapy-and-calls-for-wide-geographical-distribution-and-transparency-from-originator."},{"key":"ref4\/cit4a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.0c00233"},{"key":"ref4\/cit4b","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl4784"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4010"},{"key":"ref6\/cit6a","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.04.004"},{"key":"ref6\/cit6b","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.11.016"},{"key":"ref7\/cit7a","doi-asserted-by":"publisher","DOI":"10.1021\/cr9002165"},{"key":"ref7\/cit7b","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(00)00097-8"},{"key":"ref8\/cit8a","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.26.4.476"},{"key":"ref8\/cit8b","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(86)90039-2"},{"key":"ref8\/cit8c","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(89)90072-7"},{"key":"ref8\/cit8d","doi-asserted-by":"publisher","DOI":"10.1021\/jm970532z"},{"key":"ref8\/cit8e","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00013-X"},{"key":"ref8\/cit8f","doi-asserted-by":"publisher","DOI":"10.1038\/nature13027"},{"key":"ref8\/cit8g","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.05.015"},{"key":"ref8\/cit8h","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.11.008"},{"key":"ref9\/cit9a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01594"},{"key":"ref9\/cit9b","doi-asserted-by":"publisher","DOI":"10.1038\/nature17180"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c00489"},{"key":"ref11\/cit11a","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.0c07312"},{"key":"ref11\/cit11b","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.0c01242"},{"key":"ref11\/cit11c","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.592908"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc1560"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20542-0"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.01.035"},{"key":"ref15\/cit15a","doi-asserted-by":"publisher","DOI":"10.3390\/v10020076"},{"key":"ref15\/cit15b","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2368-8"},{"key":"ref16\/cit16a","doi-asserted-by":"publisher","DOI":"10.1055\/s-1990-20979"},{"key":"ref16\/cit16b","doi-asserted-by":"publisher","DOI":"10.1021\/ja0524043"},{"key":"ref16\/cit16c","doi-asserted-by":"publisher","DOI":"10.1021\/ja104429y"},{"key":"ref16\/cit16d","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b00419"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2011.11.055"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.bmcl.2012.02.105","volume":"22","author":"Cho A.","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2021.116364"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c01897"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.1c01920"},{"key":"ref22\/cit22a","doi-asserted-by":"publisher","DOI":"10.1021\/jm4017625"},{"key":"ref22\/cit22b","doi-asserted-by":"publisher","DOI":"10.1021\/jm501100b"},{"key":"ref23\/cit23a","doi-asserted-by":"publisher","DOI":"10.1021\/jm00224a016"},{"key":"ref23\/cit23b","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(02)00239-0"},{"key":"ref23\/cit23c","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b01963"},{"key":"ref24\/cit24a","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2017.05.014"},{"key":"ref24\/cit24b","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113069"},{"key":"ref25\/cit25a","doi-asserted-by":"publisher","DOI":"10.1021\/jm00041a022"},{"key":"ref25\/cit25b","doi-asserted-by":"publisher","DOI":"10.1016\/0223-5234(96)89169-0"},{"key":"ref25\/cit25c","doi-asserted-by":"publisher","DOI":"10.1021\/jm2013248"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/jm400201a"},{"key":"ref27\/cit27a","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.04.043"},{"key":"ref27\/cit27b","unstructured":"bKlasson, B.; Eneroth, A.; Nilson, M.; Pinho, P.; Samuelsson, B.; Sund, C. HCV Polymerase Inhibitors. WO Patent WO084165A2013."},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)01126-7"},{"key":"ref29\/cit29a","doi-asserted-by":"publisher","DOI":"10.1021\/ja0206644"},{"key":"ref29\/cit29b","doi-asserted-by":"publisher","DOI":"10.1021\/ja030204q"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201501219"},{"key":"ref31\/cit31a","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2004.12.001"},{"key":"ref31\/cit31b","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113101"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570070440"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1039\/b003562i"},{"key":"ref34\/cit34","unstructured":"Clarke, M. O. H.; Jordan, R.; Macman, R. L.; Ray, A.; Seigel, D. Methods for Treating Flaviviridae Virus Infections. WO Patent WO184668A12017."},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)91889-6"},{"key":"ref36\/cit36","unstructured":"Macman, R. L.; Parrish, J. P.; Ray, A. S.; Theodore, D. A. Methods and Compounds for Treating Paramyxoviridae Virus Infections. WO Patent WO012776A12012."},{"key":"ref37\/cit37a","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"ref37\/cit37b","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23328-0"}],"container-title":["The Journal of Organic Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.3c00754","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acs.joc.3c00754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T08:29:41Z","timestamp":1688718581000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.joc.3c00754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,5]]},"references-count":65,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2023,7,7]]}},"alternative-id":["10.1021\/acs.joc.3c00754"],"URL":"https:\/\/doi.org\/10.1021\/acs.joc.3c00754","relation":{},"ISSN":["0022-3263","1520-6904"],"issn-type":[{"value":"0022-3263","type":"print"},{"value":"1520-6904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,5]]}}}