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Two approaches have been developed: (i) solid-phase synthesis starting from amino acids immobilized on Wang resin, which allows the rapid preparation of target compounds using the cyclative cleavage strategy, and (ii) traditional solution-phase synthesis using amino acid methyl esters as the starting materials. The advantages and drawbacks of both alternatives are compared.<\/jats:p>","DOI":"10.1021\/acs.joc.4c03113","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T01:14:28Z","timestamp":1748308468000},"page":"7151-7160","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of Imidazo[2,1-\n                    <i>a<\/i>\n                    ]isoindolones via Rearrangement and Tandem Cyclization\nof Amino-Acid-Based\n                    <i>N<\/i>\n                    -Phenacyl-2-cyano-4-nitrobenzensulfonamides"],"prefix":"10.1021","volume":"90","author":[{"given":"Barbora","family":"Lemrova\u0301","sequence":"first","affiliation":[{"name":"Palacky\u0301 University , , ,","place":["Olomouc, Czech Republic, 771 46"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kater\u030cina","family":"Z\u030ca\u0301kova\u0301","sequence":"additional","affiliation":[{"name":"Palacky\u0301 University , , ,","place":["Olomouc, Czech Republic, 771 46"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-8617","authenticated-orcid":true,"given":"Miroslav","family":"Soural","sequence":"additional","affiliation":[{"name":"Palacky\u0301 University , , ,","place":["Olomouc, Czech Republic, 771 46"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"issue":"5","key":"2026090713224184900_cit1","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1139\/cjc-2016-0594","article-title":"The Truce\u2013Smiles Rearrangement\nand Related Reactions: A Review","volume":"95","author":"Henderson","year":"2017","journal-title":"Can. 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