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Minor changes to the reaction conditions or workup, or subsequent simple transformations, unlock a variety of nitrogen-rich scaffolds. Physicochemical data show tunable basicity and lipophilicity\u2500key traits for medicinal chemistry. The scaffold also supports axial stereoisomerism, adding stereochemical diversity.<\/jats:p>","DOI":"10.1021\/acs.joc.5c00224","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T03:40:59Z","timestamp":1749094859000},"page":"9319-9326","source":"Crossref","is-referenced-by-count":2,"title":["One-Step Introduction\nof Nitrogen-Containing Functional\nGroups onto Aryl Methyl Ketones: Synthesis of \u03b1-Iminoamidines\nwith Tunable Biorelevant Properties"],"prefix":"10.1021","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5683-9353","authenticated-orcid":true,"given":"Milan S.","family":"Nes\u030cic\u0301","sequence":"first","affiliation":[{"name":"University of Nis\u030c , , Vis\u030cegradska 33 , ,","place":["Nis\u030c, Serbia, 18000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3294-3444","authenticated-orcid":true,"given":"Milica D.","family":"Nes\u030cic\u0301","sequence":"additional","affiliation":[{"name":"University of Nis\u030c , , Vis\u030cegradska 33 , ,","place":["Nis\u030c, Serbia, 18000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8554-6421","authenticated-orcid":true,"given":"Dragan B.","family":"Zlatkovic\u0301","sequence":"additional","affiliation":[{"name":"University of Nis\u030c , , Vis\u030cegradska 33 , ,","place":["Nis\u030c, Serbia, 18000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4471-8001","authenticated-orcid":true,"given":"Marko V.","family":"Rodic\u0301","sequence":"additional","affiliation":[{"name":"University of Novi Sad , , Trg Dositeja Obradovic\u0301a 3 , ,","place":["Novi Sad, Serbia, 21000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1864-4248","authenticated-orcid":true,"given":"Matic","family":"Lozins\u030cek","sequence":"additional","affiliation":[{"name":"Joz\u030cef Stefan Institute , Jamova Cesta 39 , ,","place":["Ljubljana, Slovenia, 1000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-7567","authenticated-orcid":true,"given":"Niko S.","family":"Radulovic\u0301","sequence":"additional","affiliation":[{"name":"University of Nis\u030c , , Vis\u030cegradska 33 , ,","place":["Nis\u030c, Serbia, 18000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"2026090713224425400_cit1a","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0010-8545(94)80059-6","article-title":"The coordination chemistry of the\namidine ligand","volume":"133","author":"Barker","year":"1994","journal-title":"Coord. 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